GR1009073B - Rosemary and sage extracts for skin diseases - compostions and treatment methods - Google Patents

Abstract

Novelty: a new method applied for the treatment of skin, nail and scalp diseases with the use of extracts derived from Rosmarinus officinalis L. , Salvia officinalis and Salvia triloba all containing at least 15% of diterpene phenols (carsonic acid, carnosol, 12-0-methoxy-carnosic acid, 7-methyl-rosemanol, rosemanol) ) is disclosed. Purpose: to treat -by local application or oral administration- skin diseases such as vulgaris, pustular, inverse and guttate psoriasis, psoriasis affecting the nails, scalp, palms and soles, acne of any form, pityriasis disease of the type I and II, dermatitis seborrheica, dandruff, pitiriasis versicolor, folliculitis from malassezia, eczema of any type, herpes zoster, pemphigus, ichthyosis vulgaris, and lichen planus. Advantages: use of the invented non-toxic extract for the time required; preservation of its high non-toxic efficiency results free of undesirable side effects; no need of simultaneously administering other natural or synthetic products; long-lasting recession of chronic diseases.

Description

Extracts of rosemary (Rosmarinus officinalis L.) and sage (Salvia officinalis L. and Salvia triloba I..), rich in diterpene phenols, in skin diseases: Compositions and treatment methods.

DESCRIPTION

A. Introduction

For many diseases of the skin, nails and scalp, there are no satisfactory drug treatments due to the fact that the drugs used are either not very effective, or have many side effects that are increased by the need, in some chronic diseases, to administer them for a long period of time, either due to the fact that they cannot bring about radical treatment or long-term remission but are only responsible for short-term remissions, or because after stopping the drugs the disease reappears which may be of greater intensity/severity than what it was before the treatment, or because after continuous and uninterrupted administration of certain drugs the disease becomes resistant to them, i.e. these drugs cease to be effective.

For a better understanding of the aforementioned, the following example regarding psoriasis will be given, indicatively.

Psoriasis is a chronic inflammatory and hyperplastic skin disease with specific clinical features, the treatment of which includes drugs for local application and systemic administration (oral or parenteral) e.g. corticosteroids, methotrexate, cyclosporine, infliximab etc. The use of drugs is chronic, since none of them can bring about a radical treatment of the disease, while the side effects they cause are frequent and often serious. The remission of the disease caused by the usual drugs is not maintained for a long period of time (at best a few months) resulting in the need to re-administer them. [1] Taking into account the above example it is understood that for some diseases there is a need for the discovery of pharmaceutical preparations that will be highly effective, without adverse effects, that can be used for as long as necessary while maintaining both their non-toxicity and effectiveness them, and which will cause a long-term remission, as close as possible to the radical treatment of the disease for which they were applied.

The present invention presents the use of plant extracts rich in diterpene phenols (carnosic acid, carnosol, 12-o-methoxycarnosic acid, rosmanol, 7-methyl-rosmanol) derived from the leaves of rosemary (Rosmarinus officinalis L.) and/or sage leaves (Salvia officinalis and Salvia triloba synonym of Salvia fruticosa) in the appropriate medicinal form (creams, lotions, shampoos, gels, capsules and any other cosmetologically and medicinally acceptable product) for the treatment of skin diseases. In extracts of rosemary leaves (Rosmarinus officinalis L.) or sage leaves (Salvia officinalis and Salvia triloba synonym of Salvia fruticosa) the proportions of their main active ingredients, such as carnosol, carnosic acid, 12-methoxy-carnosic acid, rosmanol, 7-methyl-rosmanol, ursolic acid, oleanolic acid and betulinic acid, change according to the method of their preparation.

In various studies done in vitro or in vivo, rosemary extracts have shown strong anti-inflammatory, anti-cancer, hepatoprotective, antithrombotic, gastroprotective, antidiabetic, analgesic, antioxidant, antibacterial and antifungal activities [2];

Carnosic acid and carnosol exert antioxidant, anticancer, anti-inflammatory, hepatoprotective and neuroprotective effects[3],[4].

In a recent in vitro study, the anti-inflammatory effect of carnosic acid was demonstrated in cases of skin inflammation from various causes [5].

Rosmanol has antioxidant, anticancer and anti-inflammatory effects [2].

Rosemary extract and its substances carnosol and ursolic acid, after topical application in mice, showed strong activity against malignant, metastatic skin cancer (melanoma) [6]. Another study demonstrated the suppressive effect of rosemary on the proliferation and therefore the spread of human melanoma A375 cells [7].

Of particular interest is the study which showed that the administration of an aqueous extract of rosemary, orally, to mice at a dose of 1 gram/kilogram of body weight per day for 15 weeks, reduced the incidence of skin cancer when administered before, together with or after the application of carcinogens compared to the placebo group [8].

Carnosic acid and carnosol neutralize Propionibacterium acnes and Staphylococcus epidermidis, as does total rosemary and sage extract. This action may be useful in the treatment of acne due to the fact that the compared bacteria are involved in the pathogenesis of the disease [9], [10].

It is worth noting that the toxicity of rosemary is negligible. An acute toxicity study of rosemary showed that a dose of 2,000 mg per kilogram of body weight orally, per day, in Wistar rats, for a period of more than 2 weeks, was well tolerated, without any side effects [11].

Sage extract, rich in diterpene phenols, successfully inhibited the appearance of erythema after UV irradiation in vivo in volunteers [12].

B. Summary of the Invention

With the use of extracts of rosemary (Rosmarinus officinalis L.) and/or sage (Salvia officinalis L. and Salvia triloba L. -synonym of Salvia fruticosa-), rich in diterpene phenols (carnosic acid, carnosol, 12-o-methoxy-carnosate acid, rosmanol, 7-methyl-rosmanol) in the appropriate pharmaceutical form e.g. solutions, suspensions, ointments, creams, gels, lotions, emulsions, powders, powders, shampoos, capsules or any other cosmetologically and pharmaceutical acceptable product for application to the skin, scalp, nails or for oral administration:

A) the treatment of skin diseases such as psoriasis of all forms (plaque, pustular, guttate, palmar and inverse psoriasis), seborrheic dermatitis, dandruff, sebaceous folliculitis, dandruff, acne (all forms) is achieved, rosacea (types 1 and 2), eczema (all types), herpes zoster, pemphigus, ichthyosis and lichen planus. B) the treatment of scalp diseases such as psoriasis, seborrheic dermatitis and dandruff is achieved (considered a mild form of seborrheic dermatitis)

C) treatment of nail diseases such as psoriatic nail disease is achieved.

The final products showed high efficiency, without the need to co-administer other preparations (drugs, nutritional supplements or phytotherapy products) and without the occurrence of unwanted effects. The finished products can be used for as long as needed while maintaining their non-toxicity and effectiveness. With regard to chronic conditions, the finished products induce long-term remission, which in several cases was as close as possible to the radical treatment of the condition for which they were applied.

C. Treatment of rosemary and sage leaves. Examples of extracts.

Examples of processing rosemary and sage leaves and the resulting extracts are reported. In extracts of rosemary leaves (Rosmarinus officinalis L.) or sage leaves (Salvia officinalis and Salvia triloba synonym of Salvia fruticosa) the proportions of their main active ingredients, such as carnosol, carnosic acid, 12-methoxy-carnosic acid, rosmanol, 7-methyl-rosmanol, ursolic acid, oleanolic acid and betulinic acid, change according to the method of their preparation.

The qualitative and quantitative analysis of the extracts was done by magnetic resonance spectroscopy,<1>H-NMR at 600MHz, using deuterated chloroform and deuterated methanol as solvents, based on corresponding measurements of diterpene phenols (carnosic acid, carnosol, 12-o-methoxy- carnosic acid, rosmanol, 7-methyl-rosmanol) as mentioned in the literature. [13], [14], [15], [16], [17].

C.1, Extract I

50-200 g of rosemary [or sage] leaves are placed in a special mixer to reduce their volume and reduce them to very small pieces. They are then placed in a special brown glass or metal stainless steel bin that closes airtight. Add 1 L of methanol (or ethyl alcohol) to the bucket and close it. We leave our system in a suitable environment (not extreme temperatures, protected from light) from 3 hours to 2 months. During this time, shake the bucket with its contents 1-3 times a day. After completing the soaking time, filter the contents of the bucket with special filter paper. To the resulting filtrate, we add an equal or double volume of water to that of the filtrate. A precipitate forms and a new filtration follows. After the end of the filtration, we take the filter paper with the precipitate and place it at rest, in a suitable place, for the evaporation of the residues of the solvents used. When the precipitate is freed from most of the solvents, practically when it is dry enough to be powdered, we collect it carefully from the filter paper and place it in a porcelain mortar where with the help of a pestle we turn it into a powder. Transfer the powder to an opaque container that seals airtight. In our container we have an extract of the leaves of the rosemary plant, Rosmarinus Officinalis L. [or sage, Salvia officinalis or Salvia triloba]

C.2. Extract II

50-200 g of rosemary [or sage] leaves are placed in a special mixer to reduce their volume and reduce them to very small pieces. They are then placed in a special brown glass or metal stainless steel bin that closes airtight. Add 1 L of methanol (or ethyl alcohol) to the bucket and close it. We leave our system in a suitable environment (not extreme temperatures, protected from light) from 3 hours to 2 months. During this time, shake the bucket with its contents 1-3 times a day. After completing the soaking time, filter the contents of the bucket with special filter paper. Place the resulting filtrate in a spherical flask and evaporate it with the help of a suitable evaporator to remove the immersion solvent. The resulting powder is the extract of the leaves of rosemary, Rosmarinus Officinalis L. [or sage, Salvia officinalis or Salvia triloba]

C.3. Extract III

50-200 g of rosemary [or sage] leaves are placed in a special mixer to reduce their volume and reduce them to very small pieces. They are then placed in a special brown glass or metal stainless steel bin that closes airtight. Add 1 L of 55-70 degree ethyl alcohol to the bucket and close it. We leave our system in a suitable environment (not extreme temperatures, protected from light) from 3 hours to 2 months. During this time, shake the bucket with its contents 1-3 times a day. After completing the soaking time, filter the contents of the bucket with special filter paper. Place the resulting filtrate in a spherical flask and evaporate it with the help of a suitable evaporator to remove the immersion solvent. The resulting powder is the extract of the leaves of rosemary, Rosmarinus Officinalis L. [or sage, Salvia officinalis or Salvia triloba]

C.4. Extract IV

10 g of rosemary [or sage] leaves are placed in a special mixer to reduce their volume and reduce them to very small pieces. Then they are placed in a special container and we add 100-1000 ml of water and proceed to boiling (boiling) with the help of a heated stove. Let the system boil for 2 to 15 minutes and remove it from the heat source. Leave it for 2 to 5 minutes, stirring every 1 minute, and proceed to filter the decoction. We can follow 2 ways:

1.  Allow the filtrate to reach room temperature and place it in a glass separatory funnel adding ethyl acetate to a volume equal to half the volume of the filtrate. We take the organic phase in a spherical flask and evaporate it using a special evaporator. The resulting solid is an extract of rosemary or sage rich in diterpene phenols obtained by the decoction method. 2. Place the filtrate in a special glass vial and put it in the freezer. When the content is frozen, freeze-dry. To the resulting solid add ethyl acetate in a volume equal to 1/3 or 1/4 of the volume of the filtrate and shake vigorously. This is followed by filtration with a special glass funnel containing a membrane. We take the organic phase in a spherical flask and evaporate it using a special evaporator. The resulting solid is the rosemary or sage extract rich in diterpene phenols obtained by the decoction method.

C.4. Extract V

10 g of rosemary [or sage] leaves are placed in a special mixer to reduce their volume and reduce them to very small pieces. Then they are placed in a mixer, preferably metal, and we add 100-1000 ml of boiling water. Agitate the drug-water system for 2 to 5 minutes at 3500 to 7000 rpm. Then we stop the stirring and carry out hot filtration of the mixture with the help of filter paper. We can follow 2 ways:

1.  Allow the filtrate to reach room temperature and place it in a glass separatory funnel adding ethyl acetate to a volume equal to half the volume of the filtrate. We take the organic phase in a spherical flask and evaporate it using a special evaporator. The resulting solid is the extract of rosemary or sage rich in diterpene phenols obtained by the turboextraction method.

2. Place the filtrate in a special glass vial and put it in the freezer. When the content is frozen, freeze-dry. To the resulting solid add ethyl acetate in a volume equal to 1/3 or 1/4 of the volume of the filtrate and shake vigorously. This is followed by filtration with a special glass funnel containing a membrane. We take the organic phase in a spherical flask and evaporate it using a special evaporator. The resulting solid is the rosemary or sage extract rich in diterpene phenols obtained by the turbo-extraction method.

D. Compositions of preparations containing extracts of rosemary (Rosmarinus officinalis L.) and/or sage (Salvia officinalis and Salvia triloba -synonym of Salvia fruticosa), rich in diterpene phenols, for the treatment of skin, nail and scalp diseases .

Composition

* solutions, toothpastes, suspensions, ointments, creams, gels, lotions, shampoos, capsules or any other cosmetologically and medicinally acceptable product for treating diseases of the skin, scalp and nails.

The wide price range of the plant extract is understandable if we take into account that it can be administered as is, i.e. constituting 100% w/w of the product, in other words without the presence of excipients, or administered with the presence of excipients whenever the plant extract will is less than 100% w/w of the final product. For example, when the plant extract is a dry extract (powder) it can be applied as is, i.e. as 100% w/w of the final product, as in the case of topical application of the powder or systemic oral administration in capsule form. The same dry extract can be administered in the presence of excipients such as e.g. in cream, so the extract content will be less than 100 w/w in the final product.

By plant extract is meant the extract of rosemary and/or sage.

E. Examples of preparations

E.1. Ointment (N/L, W/O), for application to the skin and nails.

*Extracts of rosemary (Rosmarinus officinalis L) and/or sage (Salvia officinalis and Salvia triloba) rich in diterpene phenols.

E.2. Ointment (N/L, W/O), for application to the skin and nails.

* Extracts of rosemary (Rosmarinus officinalis L) and/or sage (Salvia officinalis and Salvia triloba) rich in diterpene phenols.

E.3. Cream (A/N, O/W), for application to the skin and nails.

* Extracts of rosemary (Rosmarinus officinalis L) and/or sage (Salvia officinalis and Salvia triloba) rich in diterpene phenols.

E.4. Cream (A/N, O/W), for application to the skin and nails.

* Rosemary (Rosmarinus officinalis L) and/or sage (Salvia officinalis and Salvia triloba) extracts

E.5. Cream (L/N, O/W), for application to the skin and nails.

* Extracts of rosemary (Rosmarinus officinalis L) and/or sage (Salvia officinalis and Salvia triloba) rich in diterpene phenols.

E.6. Lotion, preparation for application to the scalp

* Extracts of rosemary (Rosmarinus officinalis L) and/or sage (Salvia officinalis and Salvia triloba) rich in diterpene phenols.

E.7. Lotion, preparation for application to the scalp

* Extracts of rosemary (Rosmarinus officinalis L) and/or sage (Salvia officinalis and Salvia triloba) rich in diterpene phenols.

G. Method of preventing and treating diseases of the skin, nails and scalp, with compositions containing extracts of rosemary (Rosmarinus officinalis L) and/or sage (Salvia officinalis and Salvia triloba) rich in diterpene phenols (carnosic acid, carnosol, 12-o-methoxy-carnosic acid, rosmanol, 7-methyl-rosmanol).

The method includes the local application of appropriate pharmaceutical forms (such as creams, ointments, solutions, lotions, suspensions, gels, shampoos, foam baths, sprays, etc.), containing rosemary or sage extract, to the affected areas and around them, 1 to 5 times a day, depending on the case.

In all cases, the therapeutic effect was achieved without the occurrence of adverse effects and without the need for co-administration of drugs, nutritional supplements and phytotherapy products. The preparations can be used for as long as necessary while maintaining their non-toxicity and their effectiveness, bringing about, in the case of chronic diseases, a remission of a long period of time, which in several cases was as close as possible to the radical treatment of the disease for which were applied.

The recovery time depends on many factors such as the disease under treatment, the existence of other diseases, the duration of the disease and many times the previous treatments, which in some cases burden the general and specific health condition of the patient, delaying the treatment with the therapeutic means proposed by the present invention. For example, the use of immunosuppressive and corticosteroid anti-inflammatory drugs in the case of psoriasis, delay the healing of patients who will use rosemary and/or sage extract. Sometimes the abuse of topical corticosteroids makes the disease unresponsive to other treatment approaches.

The complete non-toxicity of the preparations described in the present invention allows their local application as often as needed. Their application on healthy skin does not cause any negative changes. This makes it possible to use the preparations to avoid the recurrence of certain diseases, that is, they can be applied to prevent them. The dosage for the prevention or maintenance of the positive effect is lower than that used for the treatment of the respective disease.

A general recommendation is to continue using the respective product even after achieving clinical treatment for 15-20 days in the same way as before.

Oral treatment includes the use of capsules containing a dry extract, the use of solutions or suspensions obtained by dissolving or suspending a dry, thick or soft extract in a mixture of water and ethyl alcohol, or the use of a fluid extract.

H. Case examples

The final products showed high efficiency, without the need to co-administer other preparations (drugs, nutritional supplements or phytotherapy products) and without the occurrence of adverse effects. The finished products can be used for as long as needed while maintaining their non-toxicity and effectiveness. With regard to chronic conditions, the finished products induce long-term remission, which in several cases was as close as possible to the radical treatment of the condition for which they were applied.

Some representative cases will be briefly mentioned so that the method of treatment may be understood.

H.1. A case of plaque psoriasis

Male, Caucasian, 71 years old with a 20-year history of plaque psoriasis. He had psoriasis on his elbows, knees, thighs and shins [Psoriasis area severity index score (PASI score) = 14.4 [18]]. He had previously used oral cyclosporine which he discontinued due to adverse effects. He was then given oral acitretin which cured his disease but had a rapid relapse after stopping the drug. He had followed homeopathy without result. In recent years he had occasionally applied corticosteroid creams which kept his disease in a stable state but he was not satisfied. The patient had arterial hypertension and benign prostatic hypertrophy under treatment.

Started applying ointment 2 times a day topically on and around the affected areas. In the first 20 days there was a worsening of the disease, due to the abrupt discontinuation of corticosteroids. Then there was a gradual decrease in the conceit of the lesions which over time became flat, from silvery to red and then pink to white, while the desquamation at first increased and then began to decrease until it stopped completely. After 5 months cure was achieved (PASI score= 0.00). In other words, there were no more psoriasis outbreaks. The patient continued to apply the cream for another 20 days, in the places he applied before, as if there was a disease.

Thirteen months later the patient maintained the state of healing without applying ointment.

H.2. A case of plaque psoriasis

A 37-year-old Caucasian woman with a history of psoriasis since the age of 17, with hypothyroidism (Hashimoto's thyroiditis) on replacement therapy. No one else in her family had psoriasis. He had previously used oral cyclosporine without the expected effect, and then injectable infliximab treatment again without success. Since then, he has not used any medication for a year. She then turned to a holistic practitioner and was prescribed magnesium salts, baking soda and oral aloe. After 3 months of treatment, she showed no change in her clinical picture. He had plaque psoriasis, with scattered psoriatic lesions of 3-4 cm on the lower and upper extremities, scattered plaques of smaller diameter on the trunk and scalp mainly in the contour (PASI score= 16.5).

She started treatment with ointment, 3 times a day and lotion to apply to the scalp, once every night before going to bed (the patient on her own initiative applied the ointment 3 times a day for only 4 weeks. After and until the end of her treatment he applied it 1-2 times a day). Due to the fact that she had stopped the immunosuppressive drugs about 1.5 years ago, there was no rebound and recurrence of the disease, therefore the course of treatment was stable and the patient's response was very fast. The swelling of the psoriatic lesions from the skin gradually decreased, their color from red became increasingly lighter. Pruritus was absent from the beginning of treatment and did not appear during treatment. Scaling of lesions first increased until it reached a maximum state, and then began to decrease until it stopped completely. At that time the lesions were flat but still red. Over time the redness disappeared and a white spot was left in its place which fully recovered over the days. There was a similar trend in the scalp. In the four months of treatment, complete healing was achieved (PASI score = 0.00), i.e. there were no more psoriatic lesions, completely satisfying the patient who had never seen her body in this state despite previous treatments.

After 7 months there was a minor relapse which was triggered by spring allergy. He started the ointment treatment again for 3 months when complete healing was again achieved. Then there were other relapses, of smaller and smaller extent - and with longer periods of remission -, which were successfully treated with the use of the ointment. No side effects were observed. The patient was satisfied with the treatment she applied.

It is worth noting that during the treatment of psoriasis, the appearance of new small psoriasis lesions is very common, but these are controlled immediately. That is, in a week they stop growing and in the second or third week they have disappeared.

H.3. A case of hyperkeratotic plantar psoriasis

Lady, Caucasian, 45 years old with psoriasis of the soles of the feet (mainly at the toes) since two years. There was no other case of psoriasis in her family. The condition bothered her in her daily life since she felt pain when walking and when standing for a long time. The patient had arterial hypertension and was receiving treatment. He had no other health problems. Previous pharmacotherapy included 10% urea cream, Centella asiatica glucoside cream, clombetazole cream and tretinoin cream without any positive results.

After 3 months he received an ointment which he applied every 12 hours. The course of treatment was gradual and steady. Complete healing was achieved at 11 months. However, the improvement in her symptoms and therefore in her everyday life had happened much earlier.

After 5 months, she experienced a very minor relapse, which was treated immediately with the application of the cream. No side effects were observed.

H.4. Case of pustular palmar palmar psoriasis Female, Caucasian, 43 years old, developed palmar palmar pustular psoriasis 1 month ago. He did not receive any medication. The patient suffered from irritable bowel syndrome and atrial fibrillation, the latter under treatment with propranolol.

Immediately start the treatment with ointment, 2 times a day. In 40 days she was cured.

Six months later the patient was still in a state of complete recovery.

H.5. A case of pustular-hyperkeratotic plantar psoriasis

A 48-year-old Caucasian man developed pustular-hyperkeratotic plantar psoriasis five years ago to such an extent that it made it difficult for him in his daily life due to the pain he felt when walking or standing. He had no other health problems. Pharmacotherapy history includes the use of corticosteroid creams with no effect and homeopathic treatment again with no positive outcome. The next step was to take strong immunosuppressive drugs by mouth but she refused.

Start applying the ointment 2 times a day. In 5 months complete healing was achieved. There were no more pimples and hyperkeratosis. His daily life returned to its original state, i.e. to the one that existed before the appearance of psoriasis. He was advised to continue applying the cream for another 20 days, which he did.

Seven months later the patient was still without clinical signs or symptoms of the disease.

H.6. A case of pustular-hyperkeratotic plantar psoriasis

A 68-year-old Caucasian woman with a 12-month history of pustular-hyperkeratotic palmar-plantar psoriasis. He had used oral acitretin for 4 months, without positive effect, and then cream containing calcipotriol and betamethasone, which was stopped after 2 months, due to non-response to treatment. She had osteoporosis, arterial hypertension and hypothyroidism, all under appropriate treatment.

He started applying the ointment to his hands and feet 3 times a day. In 9 months, complete healing was achieved, without the appearance of side effects. She was advised to continue applying the cream for another 20 days and she did.

Five years later the patient was still in a state of healing without having to use the ointment again.

H.7. A case of guttate psoriasis

A 78-year-old Caucasian woman with guttate psoriasis of the chest, back, and legs that appeared 3 months ago was started on corticosteroid creams that worsened the patient's clinical picture, leading to discontinuation.

He started the natural cream 2 times a day, stopping all other medications he was taking until then. At 5 months of treatment, complete clinical clearance was achieved. Indeed, there were no more psoriatic lesions or symptoms.

After 7 months the patient was still in a state of complete healing. No adverse effects or side effects occurred during treatment.

H.8. A case of psoriasis of the folds

47-year-old Caucasian man with inguinal fold psoriasis that occurred 2 years ago. He used cream with tacrolimus but without positive result.

He started putting oily cream 2-3 times a day on and around the affected areas. After 7 months, complete clearance occurred. One year later and after a period of intense psychological stress, there was a recurrence of the disease, which was successfully treated, in one month, by applying the fatty cream twice a day.

H.9. Case of hand eczema

50-year-old Caucasian man with eczema on the palms of his hands since 30 years. He had tried homeopathic remedies in the past without success. He started treatment with oily cream 2 to 3 times a day and was completely well after 6 months.

One year later the therapeutic effect was still maintained.

H.10. A case of facial seborrheic dermatitis

Caucasian man, 44 years old, suddenly developed extensive erythema on the forehead and on both sides of the nose. The patient had established liver damage.

Apply L/N cream, every night, to the affected areas and around them. In the first 2 days there was worsening of the redness and increased scaling of the affected areas. After the second day both the redness and the peeling started to subside. The itching symptom had been treated immediately, from the first day. The cream caused a feeling of coolness and relief in the patient from the first day. In 7 days of treatment the patient was free of symptoms and clinical signs. The patient remained in this condition for ten months when he experienced a relapse of the disease which was again successfully treated by applying the same cream over a period of 7-10 days.

It is worth noting that patients with seborrheic dermatitis are also recommended to use lotion on the scalp once a day because the Malassezia fungus, which is involved in the disease, also colonizes the scalp.

H.11. Incident of common typhoid

Male, Caucasian, 48 years old with common ichthyosis from birth, extensive throughout his body, applied fatty cream 3 times a day to all points and clinical clearance, complete healing, occurred in a period of 5 months. No side effects were observed. There was no concomitant administration of other drugs. The patient had no other disease.

H.12. A case of rosacea type I

Male, Caucasian 50 years old with rosacea type I (erythematotelangiectatic form) since 15 years. She had persistent erythema in the center of the face with swelling and was burning. The previous treatments, metronidazole and azelaic acid topical, did not satisfy them and they were stopped.

Start applying the cream twice a day, morning and night. In ten days, complete healing was achieved, i.e. there was no more redness, swelling and burning sensation. The state of remission was maintained for about 25 days where the presence of a trigger caused the relapse of the disease, which however completely resolved in a week with the repetition of the application of the cream. The course followed since then has been the same. That is, in the presence of triggering factors (such as exposure to the sun for a long time, alcohol consumption, etc.) there was a worsening which was treated effectively and without side effects by applying the cream. However, exacerbations were progressively less intense and less frequent.

H.13. A case of common acne on the face.

Female, 28 years old, Caucasian with a history of acne vulgaris on the face since 7 years. The usual medicines did not help her.

Started applying cream 2-3 times a day all over the face. In 9 months there was healing without the appearance of adverse effects, despite the long period of use.

H.14. Shingles incident

A 56-year-old Caucasian man presented with shingles at the knee site in the form of confluent lesions. He felt burning and pain of low intensity.

Started cream 2-3 times a day on and around the affected areas. In 5 days the clinical signs and symptoms had disappeared. There was no postherpetic pain and no adverse effect occurred.

H.15. Case of dandruff (mild seborrheic dermatitis) on the scalp

Male, Caucasian, 37 years old with dandruff (mild seborrheic dermatitis) on scalp since adolescence, no other health problem. She had flaky and often itchy and irritated scalp. He used various medicated shampoos to suppress the symptoms but without satisfactory results.

Started applying lotion, once every night. First there was immediate relief of itching and an increase in scaling. Then the peeling started to decrease and the existing irritation to decrease. After a week of use the scaling stopped and he was free of symptoms and clinical signs.

After 2 months she relapsed and started applying the lotion again with a successful result. Since then she has used the lotion occasionally when needed.

H.16. Case of psoriasis on the back of the hands and psoriatic onygia A 29-year-old man, Caucasian, with plaque psoriasis on the back of both hands and nails since two years (PASI score= 1.8). He had no other health problems. He used a cream containing salicylic acid and betamethasone for about 22 months without satisfactory results. Every now and then, the vicious cycle caused by corticosteroids appeared, i.e. at first they brought about healing, but after they were stopped there was a relapse or which was increasingly greater. The end result was to increase the extent of the psoriatic lesions.

Started applying greasy cream to hands and nails 2 times a day. There was an initial worsening, within 20 days, due to discontinuation of the corticosteroid cream. Then the swelling of the lesions gradually began to decrease, their color became more and more pink, the area gradually decreased, and the desquamation at first increased until it reached its maximum point and then began to decrease. At 7 months of treatment his hands were free of any clinical signs or symptoms. Complete healing was achieved (PASI score= 0.0). He continued to apply the cream for 3 more months only on the nails which were not yet completely healed. After this period of time there was no psoriatic onychium.

Eleven months later the patient was still in a state of healing in both his hands and nails.

H.17. A case of scalp psoriasis

36-year-old Caucasian male with scalp psoriasis (PASI score=3.2) since 6 years, without any other health problems. He had intermittent use of various lotions containing corticosteroids for over 4 years without satisfactory results.

Started using lotion twice a day. Initially, within 20 days, there was a sharp deterioration due to discontinuation of corticosteroids. Then a gradual improvement of the condition began until complete healing was achieved at 8 months (PASI score= 0.0). The patient was advised to continue applying lotion for 15 days, once every night. It is worth noting that during the first 4-5 days the patient felt a burning sensation when applying the lotion. This is because patients with scalp psoriasis often scratch their heads causing sores. The lotion contains alcohol which causes a burning sensation when applied to the scalp that has sores.

After 7 months the patient was still in the fully healed state.

H.18. A case of plaque psoriasis: and folds

Little girl, Caucasian, 3 years old, with plaque psoriasis since 9 months. He had psoriatic plaques on the adductors and chest (PASI score=3.0). He used cream with fusidic acid after cream with fusidic acid and betamethasone but without any effect. Her paternal grandmother also had psoriasis. It is worth noting that due to her young age it is an extremely rare occurrence.

At the request of her parents, she received an oily cream, which they applied 3 times a day to and around the psoriatic lesions. In 37 days complete healing was achieved (PASI score=0.0). It's been 11 years and the patient has been using an occasional oily cream 3 to 4 times for about 7 days, when she would see "something" starting to appear on her skin, not meaning that this "something" was definitely psoriasis.

H.19. A case of guttate psoriasis

Male, Caucasian, 28 years old with guttate psoriasis scattered all over the body, since 2 years. He used creams containing clobetasol propionate and calcipotriol, but without positive results. The patient had no other health problems.

He started applying the cream 2 to 3 times a day all over his body, meaning both the psoriatic lesions and the healthy skin in between. In 8 months there was complete healing. Follow the application of the cream for another 20 days morning and evening. After 5 years she had a small relapse which was immediately treated in less than a month by applying an oily cream 2 to 3 times a day. For 4 years there has been no recurrence of the disease.

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Claims (16)

1. Rosemary (Rosmarinus officinalis L.) and sage (Salvia officinalis and Salvia triloba) leaf extracts, which contain a minimum of 15% w/w in diterpene phenols (carnosic acid, carnosol, 12-o-methoxy-carnosic acid, 7-methyl-rosmanol and rosmanol), for use in the prevention and treatment of skin, nail and scalp diseases. 2.  Extracts according to claim 1, with the following proportions for each diterpene phenol: a. carnosic acid from 0.001% to 99% w/w. b. carnosol from 0.001% to 99% w/w. c. 12-o-methoxy-carnosic acid from 0.001% to 98% w/w. d. 7-methyl-rosmanol from 0.0% to 98% w/w. e. rosmanol from 0.0% to 98% w/w. 3. The extracts according to claim 1 may contain oleanolic acid, ursolic acid and betulinic acid up to 50% w/w in total. 4. Extracts according to claims 1,2,3 produced using solvents such as methanol, ethanol, water, acetone, dichloromethane, ethyl acetate or mixtures thereof. 5. Products containing in their composition extracts according to claims 1, 2, 3, 4 which are: A. for local application: creams, ointments, solutions, lotions, emulsions, powders, powders, suspensions, gels, shampoos, foam baths, sprays B. for oral systemic administration: dry extract in capsule form, liquid extract, solutions or suspensions obtained by dissolving or suspending a dry or thick or soft extract or a lyophilized product in a mixture of water and ethyl alcohol. 6.  Products according to claim 5, containing in the composition the extracts of rosemary (Rosmarinus officinalis L.) and/or sage (Salvia officinalis and Salvia triloba) from 0.01% to 100% w/w. 7.   Products according to claim 5,6 containing extracts of rosemary (Rosmarinus officinalis L.) and/or sage (Salvia officinalis and Salvia triloba) in the form of liposomes. 8.  Products according to claim 5,6,7 for use in the prevention and treatment of psoriasis (plaque, pustular, guttate, palmo-plantar, inverse, scalp and nail psoriasis). 9. Products according to claim 5, 6, 7 for use in the prevention and treatment of dandruff, seborrhoeic dermatitis, dandruff and seborrhoeic folliculitis (synonym of Malassezia). 10.  Products according to claim 5,6,7 for use in the prevention and treatment of acne of all forms. 11. Products according to claim 5,6,7 for use in the prevention and treatment of rosacea type I and type II. 12.  Products according to claim 5,6,7 for use in the prevention and treatment of eczema (all types). 13. Products according to claim 5,6,7 for use in the prevention and treatment of pemphigus. 14. Products according to claim 5,6,7 for use in the prevention and treatment of common ichthyosis. 15.  Products according to claim 5,6,7 for use in the prevention and treatment of lichen planus. 16. Products according to claim 5,6,7 for use in the prevention and treatment of herpes zoster