GR1007973B - Novel n-oxyiminium compounds as intermediates of an improved process for the preparation of 2,3-diaryl-5-substituted pyridines - Google Patents

Novel n-oxyiminium compounds as intermediates of an improved process for the preparation of 2,3-diaryl-5-substituted pyridines

Info

Publication number
GR1007973B
GR1007973B GR20120100336A GR20120100336A GR1007973B GR 1007973 B GR1007973 B GR 1007973B GR 20120100336 A GR20120100336 A GR 20120100336A GR 20120100336 A GR20120100336 A GR 20120100336A GR 1007973 B GR1007973 B GR 1007973B
Authority
GR
Greece
Prior art keywords
oxyiminium
diaryl
novel
preparation
improved process
Prior art date
Application number
GR20120100336A
Other languages
Greek (el)
Inventor
Θεοχαρης Βασιλειου Κοφτης
Θανος Ευαγγελου Ανδρεου
Ελλη Στυλιανου Αλεξανδρακη
Στεφανος Σωτηριου Κωτουλας
Ευστρατιος Αντωνιου Νεοκοσμιδης
Original Assignee
Φαρματεν Αβεε,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Φαρματεν Αβεε, filed Critical Φαρματεν Αβεε,
Priority to GR20120100336A priority Critical patent/GR1007973B/en
Publication of GR1007973B publication Critical patent/GR1007973B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/22—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing two or more pyridine rings directly linked together, e.g. bipyridyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)

Abstract

The present invention discloses the advantageous use of novel N-oxyiminium compounds during a pyridine annulation reaction, which is the key transformation of an improved process for the preparation of 2,3-diaryl-5-substituted pyridines and particularly etoricoxib.
GR20120100336A 2012-06-26 2012-06-26 Novel n-oxyiminium compounds as intermediates of an improved process for the preparation of 2,3-diaryl-5-substituted pyridines GR1007973B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GR20120100336A GR1007973B (en) 2012-06-26 2012-06-26 Novel n-oxyiminium compounds as intermediates of an improved process for the preparation of 2,3-diaryl-5-substituted pyridines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20120100336A GR1007973B (en) 2012-06-26 2012-06-26 Novel n-oxyiminium compounds as intermediates of an improved process for the preparation of 2,3-diaryl-5-substituted pyridines

Publications (1)

Publication Number Publication Date
GR1007973B true GR1007973B (en) 2013-09-12

Family

ID=48093009

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20120100336A GR1007973B (en) 2012-06-26 2012-06-26 Novel n-oxyiminium compounds as intermediates of an improved process for the preparation of 2,3-diaryl-5-substituted pyridines

Country Status (1)

Country Link
GR (1) GR1007973B (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1071745A2 (en) * 1998-04-24 2001-01-31 Merck & Co., Inc. Process for synthesizing cox-2 inhibitors
WO2010097802A2 (en) * 2009-02-27 2010-09-02 Cadila Healthcare Limited A process for the preparation of etoricoxib
WO2011158250A1 (en) * 2010-06-16 2011-12-22 Glenmark Generics Limited Process for preparation of 2, 3-diaryl-5-substituted pyridines and their intermediates
WO2012066570A2 (en) * 2010-11-15 2012-05-24 Virdev Intermediates Pvt. Ltd. A process for cyclooxygenase-2 selective inhibitor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1071745A2 (en) * 1998-04-24 2001-01-31 Merck & Co., Inc. Process for synthesizing cox-2 inhibitors
WO2010097802A2 (en) * 2009-02-27 2010-09-02 Cadila Healthcare Limited A process for the preparation of etoricoxib
WO2011158250A1 (en) * 2010-06-16 2011-12-22 Glenmark Generics Limited Process for preparation of 2, 3-diaryl-5-substituted pyridines and their intermediates
WO2012066570A2 (en) * 2010-11-15 2012-05-24 Virdev Intermediates Pvt. Ltd. A process for cyclooxygenase-2 selective inhibitor

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DAVIES IAN W ET AL: "Preparation and Novel Reduction Reactions of Vinamidinium Salts", JOURNAL OF ORGANIC CHEMISTRY, ACS, US, vol. 66, no. 1, 12 January 2001 (2001-01-12), pages 251 - 255, XP002592388, ISSN: 0022-3263, [retrieved on 20001209], DOI: 10.1021/JO005656P *
MAJO V J ET AL: "A general method for the synthesis of aryl [<11>C]methylsulfones: Potential PET probes for imaging cyclooxygenase-2 expression", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 15, no. 19, 1 October 2005 (2005-10-01), pages 4268 - 4271, XP025314025, ISSN: 0960-894X, [retrieved on 20051001], DOI: 10.1016/J.BMCL.2005.06.080 *
MARCOUX J-F ET AL: "A GENERAL PREPARATION OF PYRIDINES AND PYRIDONES VIA THE ANNULATION OF KETONES AND ESTERS", JOURNAL OF ORGANIC CHEMISTRY, ACS, US, vol. 66, 1 January 2001 (2001-01-01), pages 4194 - 4199, XP002326844, ISSN: 0022-3263, DOI: 10.1021/JO0155198 *

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Effective date: 20131015