GR1006934B - Immunotherapy of multiple sclerosis using mbp83-99 peptide analogues and mannan - Google Patents

Immunotherapy of multiple sclerosis using mbp83-99 peptide analogues and mannan

Info

Publication number
GR1006934B
GR1006934B GR20070100697A GR20070100697A GR1006934B GR 1006934 B GR1006934 B GR 1006934B GR 20070100697 A GR20070100697 A GR 20070100697A GR 20070100697 A GR20070100697 A GR 20070100697A GR 1006934 B GR1006934 B GR 1006934B
Authority
GR
Greece
Prior art keywords
mannan
mbp83
immunotherapy
multiple sclerosis
peptide analogues
Prior art date
Application number
GR20070100697A
Other languages
Greek (el)
Other versions
GR20070100697A (en
Inventor
Ιωαννης Ματσουκας
Θεοδωρος Τσελιος
Γεωργιος Δεραος
Νικολαος Γρηγοριαδης
Αθανασιος Λουρμποπουλος
Βασιλικη Αποστολοπουλου
Μαρια Κατσαρα
Original Assignee
Ιωαννης Ματσουκας
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ιωαννης Ματσουκας filed Critical Ιωαννης Ματσουκας
Priority to GR20070100697A priority Critical patent/GR1006934B/en
Priority to US12/743,975 priority patent/US20110142866A1/en
Priority to CN2008801252248A priority patent/CN101990545A/en
Priority to PCT/IB2008/003493 priority patent/WO2009066175A1/en
Priority to DK08851987.1T priority patent/DK2227486T3/en
Priority to ES08851987.1T priority patent/ES2627306T3/en
Priority to AU2008327638A priority patent/AU2008327638A1/en
Priority to EP08851987.1A priority patent/EP2227486B1/en
Priority to PL08851987T priority patent/PL2227486T3/en
Publication of GR20070100697A publication Critical patent/GR20070100697A/en
Publication of GR1006934B publication Critical patent/GR1006934B/en
Priority to CY20171100602T priority patent/CY1119215T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A first aspect of the invention relates to a peptide comprising the amino acid sequence of formula (I), ENPVVHFFK91NIVTP96RTP (I) wherein at least one of K91 and P96 is substituted by a natural or unnatural amino acid. A second aspect of the invention relates to a peptide comprising the amino acid sequence of formula (I), ENPVVHFFK91NIVTP96RTP (I) which is in cyclic form. Further aspects of the invention relate to conjugates of the above described peptides with mannan, pharmaceutical compositions and methods of treating autoimmune disorders.
GR20070100697A 2007-11-20 2007-11-20 Immunotherapy of multiple sclerosis using mbp83-99 peptide analogues and mannan GR1006934B (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
GR20070100697A GR1006934B (en) 2007-11-20 2007-11-20 Immunotherapy of multiple sclerosis using mbp83-99 peptide analogues and mannan
ES08851987.1T ES2627306T3 (en) 2007-11-20 2008-11-20 Peptide analogs and conjugates thereof
CN2008801252248A CN101990545A (en) 2007-11-20 2008-11-20 Peptide analogues and conjugates thereof
PCT/IB2008/003493 WO2009066175A1 (en) 2007-11-20 2008-11-20 Peptide analogues and conjugates thereof
DK08851987.1T DK2227486T3 (en) 2007-11-20 2008-11-20 Peptide Analogs and Conjugates Thereby
US12/743,975 US20110142866A1 (en) 2007-11-20 2008-11-20 Peptide analogues and conjugates thereof
AU2008327638A AU2008327638A1 (en) 2007-11-20 2008-11-20 Peptide analogues and conjugates thereof
EP08851987.1A EP2227486B1 (en) 2007-11-20 2008-11-20 Peptide analogues and conjugates thereof
PL08851987T PL2227486T3 (en) 2007-11-20 2008-11-20 Peptide analogues and conjugates thereof
CY20171100602T CY1119215T1 (en) 2007-11-20 2017-06-08 Peptide analogs and their conjugates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20070100697A GR1006934B (en) 2007-11-20 2007-11-20 Immunotherapy of multiple sclerosis using mbp83-99 peptide analogues and mannan

Publications (2)

Publication Number Publication Date
GR20070100697A GR20070100697A (en) 2009-06-12
GR1006934B true GR1006934B (en) 2010-08-26

Family

ID=40792543

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20070100697A GR1006934B (en) 2007-11-20 2007-11-20 Immunotherapy of multiple sclerosis using mbp83-99 peptide analogues and mannan

Country Status (1)

Country Link
GR (1) GR1006934B (en)

Also Published As

Publication number Publication date
GR20070100697A (en) 2009-06-12

Similar Documents

Publication Publication Date Title
IL232501A0 (en) Stable analogs of peptide and polypeptide therapeutics
NZ598356A (en) Antigenic tau peptides and uses thereof
HK1139162A1 (en) Cyclic receptor-associated protein (rap) peptides
NZ628987A (en) Extended recombinant polypeptides and compositions comprising same
EA201391756A1 (en) COMPOSITIONS, CONTAINING, METHODS, INCLUDING, AND APPLICATION OF DERIVATIVES OF DOLASTATIN, ASSOCIATED WITH NON NATURAL AMINO ACIDS
MX347200B (en) Procoagulant peptides and their derivatives and uses therefor.
MY161773A (en) Amylin analogues and pharmaceutical compositions thereof
TN2010000298A1 (en) Novel insulin derivatives having an extremely delayed time-action profile
MX2011011960A (en) Cell membrane-permeable peptides.
UA103154C2 (en) Hla-a*-1101-restricted wt1 peptide and pharmaceutical composition comprising thereof
UA118167C2 (en) Peptides and their use
MX356671B (en) Methods of inhibition of protein fucosylation in vivo using fucose analogs.
WO2010085700A3 (en) Treatment for obesity
DE602004001727D1 (en) PROCESS FOR PREPARING CYCLIC PEPTIDES
MX353301B (en) Tripeptide compositions and methods for treatment of diabetes.
WO2011038900A3 (en) Peptide analogues of glucagon for diabetes therapy
EA201492068A1 (en) PEPTID HYDROCHLORIDE SALT AND ITS APPLICATION IN COMBINATION WITH OTHER PEPTIDES IN IMMUNOTHERAPY
AR075933A1 (en) POLYPEPTIDE AND IMMUNIZATION COMPOSITIONS CONTAINING GRAM POSITIVE POLYPEPTIDES AND METHODS OF USE
EA201590601A1 (en) APPLICATION OF PEDF-DERIVED POLYPEPTIDES FOR THE TREATMENT OF OSTEOARTHRITIS
SG10201805039UA (en) Protease resistant peptides
MX2015002279A (en) Synthetic pntx(19) peptide, pharmaceutical compositions and use.
NZ589365A (en) Peptidyl diacylglycerides
WO2004106366A8 (en) Methods for synthesizing conformationally constrained peptides, peptidometics and the use thereof as synthetic vaccines
GR20070100697A (en) Immunotherapy of multiple sclerosis using mbp83-99 peptide analogues and mannan
MX2010010177A (en) Improved beta thymosin fragments.

Legal Events

Date Code Title Description
PG Patent granted
ML Lapse due to non-payment of fees

Effective date: 20110602