GR1006233B - Anti-angiogenetic peptides and utilisation method thereof - Google Patents

Anti-angiogenetic peptides and utilisation method thereof

Info

Publication number
GR1006233B
GR1006233B GR20070100638A GR20070100638A GR1006233B GR 1006233 B GR1006233 B GR 1006233B GR 20070100638 A GR20070100638 A GR 20070100638A GR 20070100638 A GR20070100638 A GR 20070100638A GR 1006233 B GR1006233 B GR 1006233B
Authority
GR
Greece
Prior art keywords
parstatin
peptides
angiogenesis
mammals
endothelial cells
Prior art date
Application number
GR20070100638A
Other languages
Greek (el)
Inventor
Νικολαος Τσοπανογλου
Μιχαηλ Μαραγκουδακις
Original Assignee
Νικολαος Τσοπανογλου
Μιχαηλ Μαραγκουδακις
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Νικολαος Τσοπανογλου, Μιχαηλ Μαραγκουδακις filed Critical Νικολαος Τσοπανογλου
Priority to GR20070100638A priority Critical patent/GR1006233B/en
Publication of GR1006233B publication Critical patent/GR1006233B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4722—G-proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to peptides being endogenically or synthetically or molecularly produced by recombinant DNA techniques in expression systems of bacteria and mammals. These peptides which are determined as parstatin represent molecules detached and freed from the mammals PAR-1 receptor after the proteolytic actuation of this last. The parstatin inhibits the multiplication, migration and differentiation of endothelial cells as well as the angiogenesis process as a whole. The parstatin peptides, the sections of the parstatin molecule, the parstatin analogs and derivatives are all applied for the therapy of diseases and troubles relating to the angiogenesis and the operation of the endothelial cells; the monoclonic or polyclonic antibodies and oligonucleotides which are selectively bound to the identified by them parstatin and its analogs constitute a method for the diagnosis and angiogenesis-related therapy.
GR20070100638A 2007-10-16 2007-10-16 Anti-angiogenetic peptides and utilisation method thereof GR1006233B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GR20070100638A GR1006233B (en) 2007-10-16 2007-10-16 Anti-angiogenetic peptides and utilisation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20070100638A GR1006233B (en) 2007-10-16 2007-10-16 Anti-angiogenetic peptides and utilisation method thereof

Publications (1)

Publication Number Publication Date
GR1006233B true GR1006233B (en) 2009-01-22

Family

ID=40466995

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20070100638A GR1006233B (en) 2007-10-16 2007-10-16 Anti-angiogenetic peptides and utilisation method thereof

Country Status (1)

Country Link
GR (1) GR1006233B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009098689A1 (en) * 2008-02-07 2009-08-13 Hadasit Medical Research Services & Development Limited Immuno-detection of a cancerous state in a subject

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009098689A1 (en) * 2008-02-07 2009-08-13 Hadasit Medical Research Services & Development Limited Immuno-detection of a cancerous state in a subject

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Legal Events

Date Code Title Description
PG Patent granted
ML Lapse due to non-payment of fees

Effective date: 20120503