GR1005589B - Multianalyte biosensors based on monolithic optoelectronic transducers - Google Patents

Multianalyte biosensors based on monolithic optoelectronic transducers

Info

Publication number
GR1005589B
GR1005589B GR20050100623A GR20050100623A GR1005589B GR 1005589 B GR1005589 B GR 1005589B GR 20050100623 A GR20050100623 A GR 20050100623A GR 20050100623 A GR20050100623 A GR 20050100623A GR 1005589 B GR1005589 B GR 1005589B
Authority
GR
Greece
Prior art keywords
time
multianalyte
label
real
array
Prior art date
Application number
GR20050100623A
Other languages
Greek (el)
Other versions
GR20050100623A (en
Inventor
Κωνσταντινος Μισιακος
Σωτηριος Κακαμπακος
Original Assignee
Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων "Δημοκριτος"
Κωνσταντινος Μισιακος
Σωτηριος Κακαμπακος
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων "Δημοκριτος", Κωνσταντινος Μισιακος, Σωτηριος Κακαμπακος filed Critical Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων "Δημοκριτος"
Priority to GR20050100623A priority Critical patent/GR20050100623A/en
Priority to PCT/GR2006/000069 priority patent/WO2007074348A2/en
Publication of GR1005589B publication Critical patent/GR1005589B/en
Publication of GR20050100623A publication Critical patent/GR20050100623A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N2021/7706—Reagent provision
    • G01N2021/7709—Distributed reagent, e.g. over length of guide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7756—Sensor type
    • G01N2021/7763—Sample through flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7776—Index

Landscapes

  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

This invention refers to a biosensor based on an array of monolithically integrated silicon optoelectronic transducers consisting of light emitters and optical waveguides that are connected to a single detector for multianalyte determinations in thesame sample with or without the use of labels. The transducers array is fabricated with integrated circuit fabrication methods. This layout facilitates the data collection and simplifies significantly the control electronics since it requires only one set of readout electronics whereas the signal multiplexing is possible through selection of a single emitter each time. Label û free detection in real û time is accomplished by modification of the optical waveguides surface with noble metal nanoparticles due to photon extinction shifts in spectral content and magnitude of these nanoparticles observed upon binding of biomolecules on their surface. Moreover, label û free detection in real û time is realized by introducing transversely to the waveguide axis patterns of another dielectric resulting in change of the optical coupling between the light emitter and the detector through the waveguide as the refractive index of the waveguideÆs superstrate changes.
GR20050100623A 2005-12-27 2005-12-27 Multianalyte biosensors based on monolithic optoelectronic transducers GR20050100623A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GR20050100623A GR20050100623A (en) 2005-12-27 2005-12-27 Multianalyte biosensors based on monolithic optoelectronic transducers
PCT/GR2006/000069 WO2007074348A2 (en) 2005-12-27 2006-12-27 Multianalyte biosensors based on monolithic optoelectronic transducers

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20050100623A GR20050100623A (en) 2005-12-27 2005-12-27 Multianalyte biosensors based on monolithic optoelectronic transducers

Publications (2)

Publication Number Publication Date
GR1005589B true GR1005589B (en) 2007-07-18
GR20050100623A GR20050100623A (en) 2007-07-23

Family

ID=37875668

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20050100623A GR20050100623A (en) 2005-12-27 2005-12-27 Multianalyte biosensors based on monolithic optoelectronic transducers

Country Status (2)

Country Link
GR (1) GR20050100623A (en)
WO (1) WO2007074348A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4407299A1 (en) * 2023-01-26 2024-07-31 Infineon Technologies AG Fluid sensor for detecting a target fluid

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4128846C2 (en) * 1991-08-30 1994-07-14 Rainer Dr Klein Integrated optical fabric sensor
US5253037A (en) * 1992-08-04 1993-10-12 Fci-Fiberchem, Inc. Optimal length for refractive index sensors
US5737457A (en) * 1994-02-25 1998-04-07 Fci - Fiberchem, Inc. Chip level waveguide sensor
US7595189B2 (en) * 1999-01-08 2009-09-29 Applied Biosystems, Llc Integrated optics fiber array
WO2000075644A1 (en) * 1999-06-05 2000-12-14 Zeptosens Ag Sensor platform and method for analysing multiple analytes
US6137117A (en) * 1999-06-21 2000-10-24 The United States Of America As Represented By The Secretary Of The Navy Integrating multi-waveguide sensor
AU2001261094A1 (en) * 2000-04-28 2001-11-12 Edgelight Biosciences, Inc. Micro-array evanescent wave fluorescence detection device
US20020085784A1 (en) * 2000-12-06 2002-07-04 Reimer Ernest M. Integrated lightguide-optoelectronic devices
GB0117230D0 (en) * 2001-07-14 2001-09-05 Marconi Applied Technologies Detecting analytes
DE10137342A1 (en) * 2001-07-31 2003-03-06 Infineon Technologies Ag Biosensor and method for detecting macromolecular biopolymers using at least one unit for immobilizing macromolecular biopolymers
GR1004178B (en) * 2001-11-29 2003-03-05 "����������" Integrated optoelectronic silicon biosensor for the detection of biomolecules labeled with chromophore groups or nanoparticles
CA2505886A1 (en) * 2002-11-13 2004-05-27 David R. Wulfman Waveguide system for detection of fluorescently labeled nucleic acid sequences

Also Published As

Publication number Publication date
WO2007074348A3 (en) 2007-10-11
GR20050100623A (en) 2007-07-23
WO2007074348A2 (en) 2007-07-05

Similar Documents

Publication Publication Date Title
US7212693B2 (en) Optical substance analyzer
CN102713609B (en) Apparatus and method for quantifying binding and dissociation kinetics of molecular interactions
JP2020508471A (en) Integrated plasmophotonic biosensor and method of use
AU2002358915A1 (en) Integrated optoelectronic silicon biosensor for the detection of biomolecules labeled with chromophore groups or nanoparticles
CN101351765A (en) Improved optical elements for waveguide-based optical touch screens
DE69909480D1 (en) Integrated optical sensor
EP1489403A4 (en) Micro-chemical system-use chip and mico-chemical system
DE60323673D1 (en) BIOS SENSOR WITH RF SIGNAL TRANSMISSION
TW201140269A (en) Photoelectric feedback sensing system
Caucheteur et al. Cell sensing with near-infrared plasmonic optical fiber sensors
Qi et al. Optical waveguide spectrometer based on thin-film glass plates
WO2007082160A3 (en) Method for increasing signal intensity in an optical waveguide sensor
CN108267428A (en) Portable reinforced surface plasma resonance biosensor
JP2003156643A5 (en)
Jing et al. Chip-scale in situ salinity sensing based on a monolithic optoelectronic chip
CN105572074B (en) A kind of refractive index detection method based on integrated light guide biologic sensor chip on piece
TW200724902A (en) Optic waveguide biiosensing device
GR1005589B (en) Multianalyte biosensors based on monolithic optoelectronic transducers
EP1507131A3 (en) Scanning unit for an optical position measuring device
CN209784187U (en) Biosensor and method for measuring the same
CN105628621B (en) The optical waveguide biosensor sensor chip that a kind of on piece without heat integrates
WO2005001520A3 (en) Serial routing of optical signals
US20220082558A1 (en) Optical sensor, system and method for detecting pathogenic germs
Savra et al. Monolithically-integrated Young interferometers for label-free and multiplexed detection of biomolecules
CN106442419B (en) Self compensation SPR optical fiber biochemical sensor

Legal Events

Date Code Title Description
PG Patent granted