GR1000785B - Processes for the preparation of mitomycin derivatives having reduced bone marrow toxicity - Google Patents

Processes for the preparation of mitomycin derivatives having reduced bone marrow toxicity

Info

Publication number
GR1000785B
GR1000785B GR890100514A GR890100514A GR1000785B GR 1000785 B GR1000785 B GR 1000785B GR 890100514 A GR890100514 A GR 890100514A GR 890100514 A GR890100514 A GR 890100514A GR 1000785 B GR1000785 B GR 1000785B
Authority
GR
Greece
Prior art keywords
processes
preparation
bone marrow
reduced bone
marrow toxicity
Prior art date
Application number
GR890100514A
Other languages
Greek (el)
Other versions
GR890100514A (en
Inventor
Diana Green
Charles Hammer
Philip S Schein
Abdolhossen Talebian
Original Assignee
Univ Georgetown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgetown filed Critical Univ Georgetown
Publication of GR890100514A publication Critical patent/GR890100514A/en
Publication of GR1000785B publication Critical patent/GR1000785B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Η εφεύρεση αναφέρεται σε ορισμένα παράγωγα μιτομυκινών Α και C και την χρήση τους για την θεραπεία βακτηριδιακών μολύνσεων και την καταστολή της ανάπτυξης των καρκινικών κυττάρων. Η εφεύρεση αναφέρεται ακόμη σε μεθόδους για την παρασκευή των παραγώγων μιτομυκίνης της εφεύρεσης. ωThe invention relates to certain derivatives of mitomycins A and C and their use in the treatment of bacterial infections and in the suppression of cancer cell growth. The invention further relates to methods for preparing the mitomycin derivatives of the invention. ω

GR890100514A 1988-08-23 1989-08-18 Processes for the preparation of mitomycin derivatives having reduced bone marrow toxicity GR1000785B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23522488A 1988-08-23 1988-08-23

Publications (2)

Publication Number Publication Date
GR890100514A GR890100514A (en) 1991-12-30
GR1000785B true GR1000785B (en) 1992-12-30

Family

ID=22884628

Family Applications (1)

Application Number Title Priority Date Filing Date
GR890100514A GR1000785B (en) 1988-08-23 1989-08-18 Processes for the preparation of mitomycin derivatives having reduced bone marrow toxicity

Country Status (16)

Country Link
EP (1) EP0431008A4 (en)
JP (1) JPH04500513A (en)
KR (1) KR900701269A (en)
CN (1) CN1040593A (en)
AU (1) AU628846B2 (en)
CA (1) CA1327037C (en)
DK (1) DK29691A (en)
ES (1) ES2018726A6 (en)
GR (1) GR1000785B (en)
IE (1) IE63036B1 (en)
IL (1) IL91332A0 (en)
NO (1) NO177673C (en)
NZ (1) NZ230343A (en)
PT (1) PT91499B (en)
WO (1) WO1990001931A1 (en)
ZA (1) ZA896025B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5091523A (en) * 1990-04-25 1992-02-25 Georgetown University Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof
EP0485904B1 (en) * 1990-11-13 1997-08-20 Kyowa Hakko Kogyo Co., Ltd. Mitomycin derivatives
GB2282384B8 (en) * 1993-08-18 1997-09-04 Europ Economic Community Drug delivery agents incorporating mitomycin
CA2958495C (en) * 2014-08-22 2023-04-18 Yafei Shanghai Biolog Medicine Science & Technology Co., Ltd. Small molecule conjugates specifically activated in tumor microenvironment for targeting and use thereof
CN104231045B (en) * 2014-08-22 2017-10-31 亚飞（上海）生物医药科技有限公司 A kind of E09 of targeted activation release and application thereof
US9801909B2 (en) 2015-04-06 2017-10-31 The Penn State Research Foundation Compositions and methods for combating bacterial infections by killing persister cells with mitomycin C

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US479130A (en) * 1892-07-19 Rudolf allert
US3226393A (en) * 1962-06-07 1965-12-28 American Cyanamid Co N-substituted derivatives of mitomycin a and mitomycin c
DE1570029A1 (en) * 1964-07-09 1970-04-09 Kyowa Hakko Kogyo Kk Process for the production of mitosan compounds
US3367945A (en) * 1965-05-18 1968-02-06 Kyowa Hakko Kogyo Kk Thiourea derivatives of mitomycin
JPS5240B2 (en) * 1973-12-17 1977-01-05
JPS5630978A (en) * 1979-08-24 1981-03-28 Kyowa Hakko Kogyo Co Ltd Novel mitomycin and its preparation
US4268676A (en) * 1979-12-05 1981-05-19 University Patents, Inc. Mitomycin analogs
US4746746A (en) * 1983-02-07 1988-05-24 University Patents, Inc. Mitomycin analogs
JPS601197A (en) * 1983-06-17 1985-01-07 Kyowa Hakko Kogyo Co Ltd Mitomycin derivative
US4814445A (en) * 1984-09-04 1989-03-21 Bristol-Myers Company Process for preparing mitomycin analogs
DE3674043D1 (en) * 1985-04-10 1990-10-18 Kyowa Hakko Kogyo Kk PHARMACOLOGICALLY ACTIVE MITOMYCINE DERIVATIVES.
US4720543A (en) * 1985-06-06 1988-01-19 Georgetown University 1a-7-substituted derivatives of mitomycin and uses thereof
JPS6354380A (en) * 1986-08-26 1988-03-08 Kyowa Hakko Kogyo Co Ltd Mitomycin derivative
JPS63246336A (en) * 1986-11-10 1988-10-13 Kyowa Hakko Kogyo Co Ltd Composition containing mitomycin-antibody complex
JPH06335575A (en) * 1993-05-28 1994-12-06 Tokyo Electric Co Ltd Shaver

Also Published As

Publication number Publication date
WO1990001931A1 (en) 1990-03-08
JPH04500513A (en) 1992-01-30
NO177673C (en) 1995-11-01
DK29691D0 (en) 1991-02-20
PT91499A (en) 1990-03-08
CN1040593A (en) 1990-03-21
NO910662L (en) 1991-03-21
AU628846B2 (en) 1992-09-24
ES2018726A6 (en) 1991-05-01
IL91332A0 (en) 1990-03-19
NZ230343A (en) 1992-01-29
GR890100514A (en) 1991-12-30
NO177673B (en) 1995-07-24
CA1327037C (en) 1994-02-15
NO910662D0 (en) 1991-02-19
PT91499B (en) 1995-07-06
EP0431008A4 (en) 1992-03-11
IE892691L (en) 1990-02-23
ZA896025B (en) 1990-05-30
EP0431008A1 (en) 1991-06-12
KR900701269A (en) 1990-12-01
AU4065089A (en) 1990-03-23
DK29691A (en) 1991-04-23
IE63036B1 (en) 1995-03-22

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