DK29691D0 - MITOMYCIN DERIVATIVES WITH REDUCED BONE MARCOX TOXICITY, PROCEDURES FOR THEIR PREPARATION AND APPLICATION - Google Patents
MITOMYCIN DERIVATIVES WITH REDUCED BONE MARCOX TOXICITY, PROCEDURES FOR THEIR PREPARATION AND APPLICATIONInfo
- Publication number
- DK29691D0 DK29691D0 DK029691A DK29691A DK29691D0 DK 29691 D0 DK29691 D0 DK 29691D0 DK 029691 A DK029691 A DK 029691A DK 29691 A DK29691 A DK 29691A DK 29691 D0 DK29691 D0 DK 29691D0
- Authority
- DK
- Denmark
- Prior art keywords
- marcox
- toxicity
- procedures
- preparation
- application
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23522488A | 1988-08-23 | 1988-08-23 | |
PCT/US1989/003180 WO1990001931A1 (en) | 1988-08-23 | 1989-07-25 | Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
DK29691D0 true DK29691D0 (en) | 1991-02-20 |
DK29691A DK29691A (en) | 1991-04-23 |
Family
ID=22884628
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK029691A DK29691A (en) | 1988-08-23 | 1991-02-20 | MITOMYCIN DERIVATIVES WITH REDUCED BONE MARCOX TOXICITY, PROCEDURES FOR THEIR PREPARATION AND APPLICATION |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0431008A4 (en) |
JP (1) | JPH04500513A (en) |
KR (1) | KR900701269A (en) |
CN (1) | CN1040593A (en) |
AU (1) | AU628846B2 (en) |
CA (1) | CA1327037C (en) |
DK (1) | DK29691A (en) |
ES (1) | ES2018726A6 (en) |
GR (1) | GR1000785B (en) |
IE (1) | IE63036B1 (en) |
IL (1) | IL91332A0 (en) |
NO (1) | NO177673C (en) |
NZ (1) | NZ230343A (en) |
PT (1) | PT91499B (en) |
WO (1) | WO1990001931A1 (en) |
ZA (1) | ZA896025B (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5091523A (en) * | 1990-04-25 | 1992-02-25 | Georgetown University | Mitomycin derivatives having reduced bone marrow toxicity, processes for their preparation, and the uses thereof |
EP0485904B1 (en) * | 1990-11-13 | 1997-08-20 | Kyowa Hakko Kogyo Co., Ltd. | Mitomycin derivatives |
GB2282384B8 (en) * | 1993-08-18 | 1997-09-04 | Europ Economic Community | Drug delivery agents incorporating mitomycin |
CN104231045B (en) * | 2014-08-22 | 2017-10-31 | 亚飞(上海)生物医药科技有限公司 | A kind of E09 of targeted activation release and application thereof |
CA2958495C (en) * | 2014-08-22 | 2023-04-18 | Yafei Shanghai Biolog Medicine Science & Technology Co., Ltd. | Small molecule conjugates specifically activated in tumor microenvironment for targeting and use thereof |
US9801909B2 (en) | 2015-04-06 | 2017-10-31 | The Penn State Research Foundation | Compositions and methods for combating bacterial infections by killing persister cells with mitomycin C |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US479130A (en) * | 1892-07-19 | Rudolf allert | ||
US3226393A (en) * | 1962-06-07 | 1965-12-28 | American Cyanamid Co | N-substituted derivatives of mitomycin a and mitomycin c |
DE1570029A1 (en) * | 1964-07-09 | 1970-04-09 | Kyowa Hakko Kogyo Kk | Process for the production of mitosan compounds |
US3367945A (en) * | 1965-05-18 | 1968-02-06 | Kyowa Hakko Kogyo Kk | Thiourea derivatives of mitomycin |
JPS5240B2 (en) * | 1973-12-17 | 1977-01-05 | ||
JPS5630978A (en) * | 1979-08-24 | 1981-03-28 | Kyowa Hakko Kogyo Co Ltd | Novel mitomycin and its preparation |
US4268676A (en) * | 1979-12-05 | 1981-05-19 | University Patents, Inc. | Mitomycin analogs |
US4746746A (en) * | 1983-02-07 | 1988-05-24 | University Patents, Inc. | Mitomycin analogs |
JPS601197A (en) * | 1983-06-17 | 1985-01-07 | Kyowa Hakko Kogyo Co Ltd | Mitomycin derivative |
US4814445A (en) * | 1984-09-04 | 1989-03-21 | Bristol-Myers Company | Process for preparing mitomycin analogs |
DE3674043D1 (en) * | 1985-04-10 | 1990-10-18 | Kyowa Hakko Kogyo Kk | PHARMACOLOGICALLY ACTIVE MITOMYCINE DERIVATIVES. |
US4720543A (en) * | 1985-06-06 | 1988-01-19 | Georgetown University | 1a-7-substituted derivatives of mitomycin and uses thereof |
JPS6354380A (en) * | 1986-08-26 | 1988-03-08 | Kyowa Hakko Kogyo Co Ltd | Mitomycin derivative |
JPS63246336A (en) * | 1986-11-10 | 1988-10-13 | Kyowa Hakko Kogyo Co Ltd | Composition containing mitomycin-antibody complex |
JPH06335575A (en) * | 1993-05-28 | 1994-12-06 | Tokyo Electric Co Ltd | Shaver |
-
1989
- 1989-07-25 AU AU40650/89A patent/AU628846B2/en not_active Ceased
- 1989-07-25 EP EP19890909473 patent/EP0431008A4/en not_active Withdrawn
- 1989-07-25 WO PCT/US1989/003180 patent/WO1990001931A1/en not_active Application Discontinuation
- 1989-07-25 KR KR1019900700816A patent/KR900701269A/en not_active Application Discontinuation
- 1989-07-25 JP JP1508792A patent/JPH04500513A/en active Pending
- 1989-08-08 ZA ZA896025A patent/ZA896025B/en unknown
- 1989-08-16 IL IL91332A patent/IL91332A0/en unknown
- 1989-08-17 NZ NZ230343A patent/NZ230343A/en unknown
- 1989-08-18 GR GR890100514A patent/GR1000785B/en unknown
- 1989-08-21 PT PT91499A patent/PT91499B/en not_active IP Right Cessation
- 1989-08-22 CN CN89106432A patent/CN1040593A/en active Pending
- 1989-08-22 IE IE269189A patent/IE63036B1/en not_active IP Right Cessation
- 1989-08-22 ES ES8902910A patent/ES2018726A6/en not_active Expired - Lifetime
- 1989-08-22 CA CA000608960A patent/CA1327037C/en not_active Expired - Fee Related
-
1991
- 1991-02-19 NO NO910662A patent/NO177673C/en unknown
- 1991-02-20 DK DK029691A patent/DK29691A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IE892691L (en) | 1990-02-23 |
NO910662D0 (en) | 1991-02-19 |
IL91332A0 (en) | 1990-03-19 |
EP0431008A4 (en) | 1992-03-11 |
GR1000785B (en) | 1992-12-30 |
NO177673B (en) | 1995-07-24 |
JPH04500513A (en) | 1992-01-30 |
ES2018726A6 (en) | 1991-05-01 |
NO177673C (en) | 1995-11-01 |
EP0431008A1 (en) | 1991-06-12 |
WO1990001931A1 (en) | 1990-03-08 |
GR890100514A (en) | 1991-12-30 |
AU4065089A (en) | 1990-03-23 |
CA1327037C (en) | 1994-02-15 |
AU628846B2 (en) | 1992-09-24 |
PT91499A (en) | 1990-03-08 |
ZA896025B (en) | 1990-05-30 |
IE63036B1 (en) | 1995-03-22 |
PT91499B (en) | 1995-07-06 |
NO910662L (en) | 1991-03-21 |
CN1040593A (en) | 1990-03-21 |
KR900701269A (en) | 1990-12-01 |
DK29691A (en) | 1991-04-23 |
NZ230343A (en) | 1992-01-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHB | Application shelved due to non-payment |