GEP20146163B - Process for preparing pharmaceutical compounds and intermediate compounds - Google Patents

Process for preparing pharmaceutical compounds and intermediate compounds

Info

Publication number
GEP20146163B
GEP20146163B GEAP201012805A GEAP2010012805A GEP20146163B GE P20146163 B GEP20146163 B GE P20146163B GE AP201012805 A GEAP201012805 A GE AP201012805A GE AP2010012805 A GEAP2010012805 A GE AP2010012805A GE P20146163 B GEP20146163 B GE P20146163B
Authority
GE
Georgia
Prior art keywords
compounds
preparing pharmaceutical
tieno
tetrahydro
intermediate compounds
Prior art date
Application number
GEAP201012805A
Inventor
Szent-Királlyi Szent-Királlyi
Angéla Pandur
Kálmán Nagy
József Debreczeni
Enikő Molnár
György Ruzsics
Bálint Nyulasi
Judit Broda
Tibor Mezei
József Barkóczy
Tamás Gregor
Balázs Volk
Márta Porcs-Makkay
Original Assignee
Egis Gyogyszergyar Nyilvanosan Mukoedo Reszvenytarsasag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyogyszergyar Nyilvanosan Mukoedo Reszvenytarsasag filed Critical Egis Gyogyszergyar Nyilvanosan Mukoedo Reszvenytarsasag
Publication of GEP20146163B publication Critical patent/GEP20146163B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Present invention relates to preparation process of 2-acetoxy-5-(2-fluor-α- cyclopropyl-carbonyl-benzyl)-4,5,6,7-tetrahydro-4H-tieno[3,2-c]pyridine ¬(prasugrel) of formula (I), wherein novel crystalline form of 5-trityl-4,5,6,7-tetrahydro-tieno[3,2-c] pyri¬dine is applied as starting product. 3 dependent
GEAP201012805A 2009-12-21 2010-12-21 Process for preparing pharmaceutical compounds and intermediate compounds GEP20146163B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0900794A HU229031B1 (en) 2009-12-21 2009-12-21 Process for producing prasurgel and its intermediate

Publications (1)

Publication Number Publication Date
GEP20146163B true GEP20146163B (en) 2014-09-10

Family

ID=89989451

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP201012805A GEP20146163B (en) 2009-12-21 2010-12-21 Process for preparing pharmaceutical compounds and intermediate compounds

Country Status (8)

Country Link
US (1) US9169265B2 (en)
EP (1) EP2516447A1 (en)
BR (1) BR112012015233A2 (en)
EA (1) EA023057B1 (en)
GE (1) GEP20146163B (en)
HU (1) HU229031B1 (en)
UA (1) UA110608C2 (en)
WO (1) WO2011077174A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102775422B (en) * 2012-03-13 2014-12-31 山东新华制药股份有限公司 Crystal form of Prasugrel intermediate

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2576901B1 (en) 1985-01-31 1987-03-20 Sanofi Sa NOVEL DERIVATIVES OF A- (OXO-2 HEXAHYDRO-2,4,5,6,7,7A THIENO (3,2-C) PYRIDYL-5) ACETIC PHENYL, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATION
FI101150B (en) 1991-09-09 1998-04-30 Sankyo Co Process for the preparation of tetrahydrothione nopyridine derivatives useful as a drug
US5874581A (en) 1994-10-07 1999-02-23 Ube Industries, Ltd. 2-silyloxy-tetrahydrothienopyridine, salt thereof and process for preparing the same
RU2161282C1 (en) 1999-05-13 2000-12-27 Багнюков Сергей Анатольевич Gas cylinder and method for charging it
PL2007362T3 (en) 2006-04-04 2019-02-28 Kg Acquisition Llc Oral dosage forms including an antiplatelet agent and an acid inhibitor
TWI392681B (en) 2006-04-06 2013-04-11 Daiichi Sankyo Co Ltd Prasugrel with high purity and a method for preparing its acid addition salt
JP2007303860A (en) 2006-05-09 2007-11-22 Fujikura Ltd Magnetic device
CA2679925C (en) 2007-03-02 2012-10-02 Daiichi Sankyo Company, Limited Method for producing high-purity prasugrel hydrochloride
CZ302135B6 (en) 2007-07-09 2010-11-10 Zentiva, A. S. Process for preparing 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4, 5, 6, 7-tetrahydrothieno[3,2-c]-pyridin-2-yl acetate (prasugrel)
EP2205611A4 (en) 2007-11-09 2012-02-22 Reddys Lab Ltd Dr Processes for the preparation of prasugrel, and its salts and polymorphs
WO2009066326A2 (en) 2007-11-19 2009-05-28 Msn Laboratories Limited Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts
CN101177430A (en) 2007-12-11 2008-05-14 鲁南制药集团股份有限公司 Hydrogenated pyridine derivative and method for preparing salt thereof
CN101245072B (en) 2008-03-21 2011-03-30 上海医药工业研究院 Intermediate for producing prasugrel and producing method thereof
CN101245073B (en) 2008-03-21 2011-03-23 上海医药工业研究院 Medicine intermediate and preparation method thereof
CN101250192B (en) 2008-03-24 2010-08-11 上海医药工业研究院 Method for preparing 5-(alpha-cyclopropyl carbonyl-2-fluorobenzyl)-2-oxo-2,4,5,6,7,7a-hexahydrothiophene [3,2-c] pyridine
CN101250193B (en) 2008-03-28 2010-09-08 上海医药工业研究院 Method for preparing 2-methoxy-5-(alpha-cyclopropyl carbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothiophene [3,2-c] pyridine

Also Published As

Publication number Publication date
HUP0900794A2 (en) 2011-10-28
HU229031B1 (en) 2013-07-29
HU0900794D0 (en) 2010-03-01
EP2516447A1 (en) 2012-10-31
US20120330018A1 (en) 2012-12-27
BR112012015233A2 (en) 2015-09-22
EA201290535A1 (en) 2013-05-30
UA110608C2 (en) 2016-01-25
EA023057B1 (en) 2016-04-29
WO2011077174A1 (en) 2011-06-30
US9169265B2 (en) 2015-10-27

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