GEP19970820B - Method of obtaining sulfinyl thionyl derivatives of heterogeneous ring compounds or their pharmaceutically acceptable salts - Google Patents
Method of obtaining sulfinyl thionyl derivatives of heterogeneous ring compounds or their pharmaceutically acceptable saltsInfo
- Publication number
- GEP19970820B GEP19970820B GEAP1993814A GEAP1993000814A GEP19970820B GE P19970820 B GEP19970820 B GE P19970820B GE AP1993814 A GEAP1993814 A GE AP1993814A GE AP1993000814 A GEAP1993000814 A GE AP1993000814A GE P19970820 B GEP19970820 B GE P19970820B
- Authority
- GE
- Georgia
- Prior art keywords
- alkyl
- group
- substituted
- optionally
- pharmaceutically acceptable
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- -1 sulfinyl thionyl Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 239000005864 Sulphur Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000003709 fluoroalkyl group Chemical group 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000027119 gastric acid secretion Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000012038 nucleophile Substances 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
There are described compounds of formula I, (See formula I) in which Rc is a nucleophilic nitrogen, oxygen or- sulphur separated from the SO group by 1, 2, 3, 4 or 5 other atoms, R1, R2, R3 and R4, which may be the same or different, are each hydrogen, halogen, alkoxy, alkyl, fluoroalkyl, alkanoyl, RS (O)n-, -NO2, -N(R)2, -NHCOR, or -COOH or an ester or amide thereof, or an adjacent pair of R1, R2, R3 and R4 may in addition to the values given above, together form a chain -(CH2)x- or, together with the carbon atoms to which they are attached, form a 6 membered unsaturated carbocylic or nitrogen heterocyclic ring, x is 3, 4 or 5, n is 0, 1 or 2, X i s 0 , S or NR15, R15 is hydrogen, -COR, -COOR or alkyl which latter is optionally substituted by -OCOR, R is phenyl, or alkyl optionally substituted by phenyl, t'he phenyl groups in turn optionally being substituted by alkyl, provided that i); Rc is not -CH2CH2-morpholino, ii) that when Rc is a nitrogen nucleophile carried on an aryl or heteroaryl group R15 is not a group -COR in which R, is unsubstituted alkyl, iii) when X is NR15 Rc does not comprise an unsaturated nitrogen heterocyclic ring other than such a ring substituted by a either a) a substituted or unsubstituted amino group, or b) an N-oxido group, and iv) when X is NR15Rc does not comprise an alkyl group substituted by an optionally alkyl or halo substituted piperidino group, and pharmaceutically acceptable salts thereof. There are also described processes for making the compounds, and their formulation and use as pharmaceuticals, e.g. to treat gastric acid secretion.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848430163A GB8430163D0 (en) | 1984-11-29 | 1984-11-29 | Biologically active nitrogen heterocycles |
| GB858509406A GB8509406D0 (en) | 1985-04-12 | 1985-04-12 | Nitrogen heterocycles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GEP19970820B true GEP19970820B (en) | 1997-02-10 |
Family
ID=26288504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GEAP1993814A GEP19970820B (en) | 1984-11-29 | 1993-05-31 | Method of obtaining sulfinyl thionyl derivatives of heterogeneous ring compounds or their pharmaceutically acceptable salts |
Country Status (3)
| Country | Link |
|---|---|
| GE (1) | GEP19970820B (en) |
| HU (1) | HU198695B (en) |
| SU (1) | SU1524807A3 (en) |
-
1985
- 1985-11-25 HU HU854489A patent/HU198695B/en unknown
- 1985-11-28 SU SU853979903A patent/SU1524807A3/en active
-
1993
- 1993-05-31 GE GEAP1993814A patent/GEP19970820B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUT39730A (en) | 1986-10-29 |
| HU198695B (en) | 1989-11-28 |
| SU1524807A3 (en) | 1989-11-23 |
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