GB996308A - New 19-nor-steroids - Google Patents

New 19-nor-steroids

Info

Publication number
GB996308A
GB996308A GB11229/62A GB1122962A GB996308A GB 996308 A GB996308 A GB 996308A GB 11229/62 A GB11229/62 A GB 11229/62A GB 1122962 A GB1122962 A GB 1122962A GB 996308 A GB996308 A GB 996308A
Authority
GB
United Kingdom
Prior art keywords
group
hydrocarbon
sulphonyloxy
steroids
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB11229/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Laboratories Ltd
Original Assignee
Organon Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Laboratories Ltd filed Critical Organon Laboratories Ltd
Publication of GB996308A publication Critical patent/GB996308A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises steroids of the formula <FORM:0996308/C2/1> (wherein R1 is OH or Oacyl, and R2 is a saturate or unsaturated hydrocarbon radical of at most 4 carbon atoms, or R1 and R2 together are a keto group) and their preparation by splitting off the 3-substituent from a corresponding 3-halo or -sulphonyloxy steroid (wherein the the sulphonyloxy group is an aliphatic, aromatic or araliphatic hydrocarbon-sulphonyloxy group) by reduction. The product or the starting material, if 17-ol, may be oxidized to the 17-one, which may be reacted with a hydrocarbon metal compound to give the 17a -hydrocarbon-17b -ol. In this, an alkynyl group may be reduced to an alkenyl or alkyl group. 17-ols may be esterified, and 17-esters hydrolysed. Examples are given. The preparation of the starting materials is described in Specification 996,309. The 3-unsubstituted steroids of the invention, which are stated to have progestative, gonad-inhibiting and estrogenic activity, may be made up into pharmaceutical compositions with inert carriers.
GB11229/62A 1961-03-29 1962-03-23 New 19-nor-steroids Expired GB996308A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL262988 1961-03-29

Publications (1)

Publication Number Publication Date
GB996308A true GB996308A (en) 1965-06-23

Family

ID=19752951

Family Applications (2)

Application Number Title Priority Date Filing Date
GB39822/63A Expired GB996309A (en) 1961-03-29 1962-03-23 New 19-nor steroids
GB11229/62A Expired GB996308A (en) 1961-03-29 1962-03-23 New 19-nor-steroids

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB39822/63A Expired GB996309A (en) 1961-03-29 1962-03-23 New 19-nor steroids

Country Status (7)

Country Link
US (1) US3312720A (en)
BE (1) BE615712A (en)
CH (1) CH454131A (en)
DE (1) DE1299635B (en)
DK (2) DK106038C (en)
GB (2) GB996309A (en)
SE (1) SE306530B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3383393A (en) * 1963-11-20 1968-05-14 Organon Novel 7-alkyl-19-nor-steroids
US3983144A (en) * 1973-12-19 1976-09-28 Akzona Incorporated Novel 11β-alkyl steroids of the estrane series

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2184299A (en) * 1934-08-22 1939-12-26 Schering Corp Keto cyclopentano dimethyl polyhydro phenanthroles and a method of producing the same
US2189130A (en) * 1935-10-07 1940-02-06 Schering Corp Reduction products derived from dehydroandrosterone and method of producing the same
US2243887A (en) * 1935-11-09 1941-06-03 Schering Corp Tertiary carbinols of the cyclopentano-polyhydrophenanthrene series and a method of producing the same
GB556734A (en) * 1940-01-17 1943-10-20 Chem Ind Basel Manufacture of compounds of the ring-d-homo-steroid series

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3383393A (en) * 1963-11-20 1968-05-14 Organon Novel 7-alkyl-19-nor-steroids
US3983144A (en) * 1973-12-19 1976-09-28 Akzona Incorporated Novel 11β-alkyl steroids of the estrane series

Also Published As

Publication number Publication date
DE1299635B (en) 1969-07-24
SE306530B (en) 1968-12-02
DK106090C (en) 1966-12-19
CH454131A (en) 1968-04-15
BE615712A (en) 1962-09-28
GB996309A (en) 1965-06-23
DK106038C (en) 1966-12-12
US3312720A (en) 1967-04-04

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