GB994705A - Anti-bacterial compositions - Google Patents

Anti-bacterial compositions

Info

Publication number
GB994705A
GB994705A GB9251/62A GB925162A GB994705A GB 994705 A GB994705 A GB 994705A GB 9251/62 A GB9251/62 A GB 9251/62A GB 925162 A GB925162 A GB 925162A GB 994705 A GB994705 A GB 994705A
Authority
GB
United Kingdom
Prior art keywords
trifluoromethyl
sodium
halogen
hydrogen
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB9251/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Procter and Gamble Co
Original Assignee
Procter and Gamble Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co
Publication of GB994705A publication Critical patent/GB994705A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
    • A61K31/621—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate having the hydroxy group in position 2 esterified, e.g. benorylate
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/30—Derivatives containing the group >N—CO—N aryl or >N—CS—N—aryl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dentistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)

Abstract

Anti-bacterial compositions comprise in synergistic combination (1) at least one halogenated salicylanilide having the formula <FORM:0994705/C4-C5/1> wherein the groups X1, which may be the same or different, are hydrogen or halogen, X2 is halogen, and the groups Y, which may be the same or different, are hydrogen, halogen or trifluoromethyl, and (2) at least one trifluoromethyl diphenyl urea having the formula <FORM:0994705/C4-C5/2> wherein X3 is halogen or ethoxy, Z is hydrogen or trifluoromethyl, and X1 and Y have the meaning given above; the weight ratio of halogenated salicylanilide to trifluoromethyl diphenyl urea being from 1: 20 to 20: 1. Salicylanilides specified are 3,5,41 - tribromosalicylanilide, 5 - bromosalicyl - 3,5-di-(tri-fluoromethyl)anilide, 5 - chlorosalicyl - 3,5-di-(trifluoromethyl)anilide, 3,5 - dichlorosalicyl - 3,4 - dichloroanilide and 5 - chlorosalicyl - 3 - trifluoromethyl - 4 - chloroanilide; other suitable compounds are described in Specification 745,607. The preferred urea compounds are 3 - trifluoromethyl - 4,41-dichlorocarbanilide 3 - trifluoromethyl - 31,4,41-trichlorocarbanilide, 3,31 - bis - (trifluoromethyl) - 4 - ethoxy - 41 - chlorocarbanilide and 3,5 - bis - (trifluoromethyl) - 4 - chlorocarbanilide; some of these and other suitable urea compounds are described in Specification 774,802. The active ingredients may be used with soaps, e.g. sodium, potassium and magnesium soaps of tallow and coconut fatty acids, and with anionic or non-ionic synthetic detergents. Anionic detergents mentioned are sulphated and sulphonated compounds such as sodium or potassium alkyl sulphates; sodium or potassium alkyl benzene sulphonates; sodium alkyl glyceryl ether sulphonates; sodium coconut oil fatty acid monoglyceride sulphates and sulphonates; sodium salts of sulphuric acid esters of reaction products of higher fatty alcohols and ethylene oxide. Non-ionic detergents mentioned are condensation products of alkylene oxides and organic hydrophobic compounds such as the "Pluronic" (Trade Mark) detergents formed by condensing ethylene oxide with the condensation product of propylene oxide and propylene glycol; polyethylene oxide condensates of alkyl phenols; condensate of ethylene oxide with the reaction product of propylene oxide and ethylenediamine. The use of sodium and potassium chlorides and sulphates, sodium tripolyphosphate and silicate solids is also mentioned. The anti-bacterial compositions may take the form of toilet detergent bars and granular laundry detergent compositions. Specifications 596,560, 614,044, 645,129 and 774,802 also are referred to.ALSO:Anti-bacterial compositions comprise in synergistic combination (1) at least one halogenated salicylanilide having the formula <FORM:0994705/A5-A6/1> wherein the groups X1, which may be the same or different, are hydrogen or halogen, X2 is halogen, and the groups Y, which may be the same or different, are hydrogen, halogen or trifluoromethyl, and (2) at least one trifluoromethyl diphenyl urea having the formula <FORM:0994705/A5-A6/2> wherein X3 is halogen or ethoxy, Z is hydrogen or trifluoromethyl, and X1 and Y have the meaning given above; the weight ratio of halogenated salicylanilide to trifluoromethyl diphenyl urea being from 1 : 20 to 20 : 1. Salicylanilides specified are 3,5,4 - tribromosalicylanilide, 5 - bromosalicyl - 3,5 di(trifluoromethyl)anilide, 5 - chlorosalicyl - 3,5 - di (trifluoromethyl)anilide, 3,5 - dichlorosalicyl-3,4 - dichloroanilide and 5 - chlorosalicyl - 3-trifluoromethyl - 4 - chloroanilide; other suitable compounds are described in Specification 745,607. The preferred urea compounds are 3-trifluoromethyl - 4,41 - dichlorocarbanilide, 3-trifluoromethyl - 31,4,41 - trichlorocarbanilide, 3,31 - bis(trifluoromethyl) - 41 - ethoxy - 41 - chlorocarbanilide and 3,5 - bis(trifluoromethyl) - 4 - chlorocarbanilide; some of these and other suitable urea compounds are described in Specification 774,802. The active ingredients may be used with soaps, e.g. sodium, potassium and magnesium soaps of tallow and coconut fatty acids, and with anionic or non-ionic synthetic detergents. The anti-bacterial compositions may take the form of toilet detergent bars, laundry detergent compositions, tooth powders, toothpastes, mouth washes, antiseptic ointments and foot powders. Specifications 596,560, 614,044, and 645,129 also are referred to.
GB9251/62A 1961-03-09 1962-03-09 Anti-bacterial compositions Expired GB994705A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94437A US3134711A (en) 1961-03-09 1961-03-09 Halogenated salicylanilide-halogenated trifluoromethyldiphenyl urea synergistic composition
US320598A US3256200A (en) 1961-03-09 1963-10-11 Anti-bacterial detergent composition

Publications (1)

Publication Number Publication Date
GB994705A true GB994705A (en) 1965-06-10

Family

ID=26788878

Family Applications (1)

Application Number Title Priority Date Filing Date
GB9251/62A Expired GB994705A (en) 1961-03-09 1962-03-09 Anti-bacterial compositions

Country Status (4)

Country Link
US (2) US3134711A (en)
DE (1) DE1158216B (en)
GB (1) GB994705A (en)
NL (2) NL120998C (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL283081A (en) * 1961-09-11
US3303136A (en) * 1963-02-26 1967-02-07 Lever Brothers Ltd Detergent compositions
US3244585A (en) * 1964-01-29 1966-04-05 Herbert C Stecker Stabilized halosalicylanilide germicides
US3989827A (en) * 1965-10-22 1976-11-02 Colgate-Palmolive Company Antibacterial composition
US4118332A (en) * 1965-10-22 1978-10-03 Colgate-Palmolive Company Synergistic antibacterial composition containing mixtures of certain halogenated diphenyl ethers and trichlorocarbanilides
US3981814A (en) * 1973-09-18 1976-09-21 Givaudan Corporation Bacteriostatic substituted benzanilide compositions and methods for their use
EP0496433B1 (en) 1987-10-22 1999-03-24 The Procter & Gamble Company Photoprotection compositions comprising chelating agents
GB2243615B (en) * 1990-05-04 1993-03-31 Procter & Gamble Beta-phase soap bars including those containing low level of moisture and solubilized solid antibacterial agent
US6190675B1 (en) 1997-06-04 2001-02-20 Procter & Gamble Company Mild, rinse-off antimicrobial liquid cleansing compositions which provide improved residual benefit versus gram positive bacteria
US6190674B1 (en) 1997-06-04 2001-02-20 Procter & Gamble Company Liquid antimicrobial cleansing compositions
US6210695B1 (en) 1997-06-04 2001-04-03 The Procter & Gamble Company Leave-on antimicrobial compositions
US6197315B1 (en) 1997-06-04 2001-03-06 Procter & Gamble Company Antimicrobial wipes which provide improved residual benefit versus gram negative bacteria
US6287577B1 (en) 1997-11-12 2001-09-11 The Procter & Gamble Company Leave-on antimicrobial compositions which provide improved residual benefit versus gram positive bacteria
US5968539A (en) * 1997-06-04 1999-10-19 Procter & Gamble Company Mild, rinse-off antimicrobial liquid cleansing compositions which provide residual benefit versus gram negative bacteria
US6214363B1 (en) 1997-11-12 2001-04-10 The Procter & Gamble Company Liquid antimicrobial cleansing compositions which provide residual benefit versus gram negative bacteria
US6183763B1 (en) 1997-06-04 2001-02-06 Procter & Gamble Company Antimicrobial wipes which provide improved immediate germ reduction
US6284259B1 (en) 1997-11-12 2001-09-04 The Procter & Gamble Company Antimicrobial wipes which provide improved residual benefit versus Gram positive bacteria
US6183757B1 (en) 1997-06-04 2001-02-06 Procter & Gamble Company Mild, rinse-off antimicrobial cleansing compositions which provide improved immediate germ reduction during washing
US6287583B1 (en) 1997-11-12 2001-09-11 The Procter & Gamble Company Low-pH, acid-containing personal care compositions which exhibit reduced sting
US7319112B2 (en) * 2000-07-14 2008-01-15 The Procter & Gamble Co. Non-halogenated antibacterial agents and processes for making same
US20020014178A1 (en) * 2000-07-14 2002-02-07 Haught John Christian Biocide compositions and methods and systems employing same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2703332A (en) * 1955-03-01 Poly halo-salicylanilioes
US2745874A (en) * 1953-06-18 1956-05-15 Geigy Ag J R Insecticidal derivatives of diphenyl urea
US2951786A (en) * 1955-01-14 1960-09-06 Spencer Chem Co Bactericidal and fungicidal compositions comprising pentahalophenyl n-(phenyl) carbamates
US2995488A (en) * 1955-03-24 1961-08-08 Fmc Corp Synergistic insecticidal compositions
US2965575A (en) * 1957-05-27 1960-12-20 Monsanto Chemicals Antiseptic detergent compositions
US3057920A (en) * 1957-12-05 1962-10-09 Lever Brothers Ltd Process for preparing 3, 4', 5-tribromosalicylanilide in acetic acid
BE582118A (en) * 1958-04-25
US3041236A (en) * 1959-09-18 1962-06-26 Herbert C Stecker Germicides containing trifluoromethyl halogenated salicylanilides

Also Published As

Publication number Publication date
NL120998C (en)
NL275155A (en)
US3134711A (en) 1964-05-26
DE1158216B (en) 1963-11-28
US3256200A (en) 1966-06-14

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