GB994275A - Improvements in or relating to endoprostheses - Google Patents

Improvements in or relating to endoprostheses

Info

Publication number
GB994275A
GB994275A GB2108362A GB2108362A GB994275A GB 994275 A GB994275 A GB 994275A GB 2108362 A GB2108362 A GB 2108362A GB 2108362 A GB2108362 A GB 2108362A GB 994275 A GB994275 A GB 994275A
Authority
GB
United Kingdom
Prior art keywords
proteins
treated
moulded
plasticizer
mixed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2108362A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of GB994275A publication Critical patent/GB994275A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/06—At least partially resorbable materials
    • A61L17/08—At least partially resorbable materials of animal origin, e.g. catgut, collagen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Materials For Medical Uses (AREA)

Abstract

A protein composition is moulded under pressure to form surgical endoprosthesis absorbable in the body, the composition comprising a mixture of human or animal proteins and a plasticizer, the proteins being albumin, actomyosin, myosin, actin, collagen, elastin or fibrin. The protein, which is isolated by conventional methods, is treated with a dehydrating agent, e.g. acetone or ethanol, dried and ground. Different proteins are mixed in desired proportions to provide materials of desired properties. The powdered proteins are then mixed with a plasticizer and moulded. Plasticizers used are dihydric and trihydric alcohols, ethylene glycol, propylene glycol or glycerol. The moulded material may be treated to increase its resistance to attack by tissue enzymes or to improve its elastic properties.ALSO:Absorbable endoprostheses e.g. pins, nails, screws, plugs, tubes for substitute trachea, sleeves, cups, buttons, rings, bars, are made by moulding under pressure a mixture of powdered human or animal protein and a plasticizer, the proteins being selected from albumin, actomyosin, myosin, actin, collagen, elastin or fibrin. The proteins are isolated from blood, bone or tissue by conventional methods, treated with a dehydrating agent, e.g. acetone or ethanol, dried and ground. Different proteins are mixed in desired proportions to provide materials of different properties. The powdered proteins are then mixed with a plasticizer and moulded to the desired shape. Plasticizers used are dihydric and trihydric alcohols, ethylene glycol, propylene glycol or glycerol. The moulded prostheses are treated in a bath with aluminium or chromium salts, formaldehyde, acetaldehyde, ethylene chloride or epoxides to increase their resistance to attach by tissue enzymes. They may also be treated with ethylene glycol or glycerol to improve their elastic properties.
GB2108362A 1961-05-31 1962-05-31 Improvements in or relating to endoprostheses Expired GB994275A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HUGE000368 1961-05-31

Publications (1)

Publication Number Publication Date
GB994275A true GB994275A (en) 1965-06-02

Family

ID=10996514

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2108362A Expired GB994275A (en) 1961-05-31 1962-05-31 Improvements in or relating to endoprostheses

Country Status (3)

Country Link
DE (1) DE1745676B1 (en)
DK (1) DK107887C (en)
GB (1) GB994275A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0069156A1 (en) * 1981-07-02 1983-01-12 Intermedicat GmbH Method for the preparation of transplants with higher biological stability
EP0169259A1 (en) * 1984-07-25 1986-01-29 Surgical Patent Products Inc. Ltd. Vascular prostheses for dry preservation, method of conditioning and their use in surgery
WO1998040112A1 (en) * 1997-03-10 1998-09-17 Meadox Medicals, Inc. Self-aggregating protein compositions and use as sealants

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6013853A (en) * 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE358540C (en) * 1915-08-01 1922-09-12 Gottfried Diesser Process for the production of water-insoluble bodies from glycerine and albumins
US2385803A (en) * 1942-02-09 1945-10-02 Research Corp Process for the manufacture of plastic compositions
DE849165C (en) * 1951-03-01 1952-09-11 Nordmark Werke Gmbh Process for the production of threads, films and foams from fibrin

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0069156A1 (en) * 1981-07-02 1983-01-12 Intermedicat GmbH Method for the preparation of transplants with higher biological stability
EP0169259A1 (en) * 1984-07-25 1986-01-29 Surgical Patent Products Inc. Ltd. Vascular prostheses for dry preservation, method of conditioning and their use in surgery
WO1998040112A1 (en) * 1997-03-10 1998-09-17 Meadox Medicals, Inc. Self-aggregating protein compositions and use as sealants

Also Published As

Publication number Publication date
DE1745676B1 (en) 1970-07-02
DK107887C (en) 1967-07-17

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