GB988616A - New sulphanilamido-pyrazoles and pharmaceutical preparations containing them - Google Patents
New sulphanilamido-pyrazoles and pharmaceutical preparations containing themInfo
- Publication number
- GB988616A GB988616A GB15169/61A GB1516961A GB988616A GB 988616 A GB988616 A GB 988616A GB 15169/61 A GB15169/61 A GB 15169/61A GB 1516961 A GB1516961 A GB 1516961A GB 988616 A GB988616 A GB 988616A
- Authority
- GB
- United Kingdom
- Prior art keywords
- substituent
- group
- amino
- compounds
- pyrazoles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/42—Benzene-sulfonamido pyrazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises sulphanilamidopyrazoles of the formula <FORM:0988616/C2/1> in which R is Cl, Br or CF3 or a C1- 4 alkyl or alkoxy group, e.g. CH3, C2H5, CH3O and C2H5O, and physiologically tolerable salts of these compounds with inorganic or organic bases such as alkali and alkaline earth metals, ammonium and diethylaminoethanol. The compounds are made by reacting a benzenesulphonyl halide bearing a p-substituent convertible into an amino group by hydrolysis or reduction, such as an acetylamino, carbethoxyamino, nitro or chlorosulphonylphenylazo group, with an appropriate 3-amino-pyrazole which may optionally have a substituent exchangeable for a hydrogen atom in the 4-position, converting the p-substituent into an amino group and, if necessary exchanging the substituent in the 3-position or any further sulphonyl radical which may have been introduced, for a hydrogen atom. 2 - Phenyl - 3 - amino - 5 - methyl - pyrazoles bearing a substituent R on the phenyl group, which are used as starting materials are made by the reaction of diacetonitrile with an appropriately substituted phenyl hydrazine. Pharmaceutical preparations for the treatment of bacterial infections comprise the above compounds of the invention in admixture or conjunction with a pharmaceutical carrier. The preparations may be in forms suitable for oral or parenteral administration, for example, tablets, capsules, dragees, solutions or suspensions.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEF31083A DE1166784B (en) | 1960-04-26 | 1960-04-26 | Process for the preparation of sulfanilamidopyrazoles |
DEF33204A DE1175681B (en) | 1961-02-15 | 1961-02-15 | Process for the preparation of sulfanilamidopyrazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
GB988616A true GB988616A (en) | 1965-04-07 |
Family
ID=25974655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB15169/61A Expired GB988616A (en) | 1960-04-26 | 1961-04-26 | New sulphanilamido-pyrazoles and pharmaceutical preparations containing them |
Country Status (7)
Country | Link |
---|---|
BE (1) | BE603078A (en) |
CH (1) | CH406229A (en) |
FR (1) | FR1327M (en) |
GB (1) | GB988616A (en) |
NL (2) | NL6517177A (en) |
OA (1) | OA02570A (en) |
SE (1) | SE305876B (en) |
-
0
- NL NL125249D patent/NL125249C/xx active
-
1961
- 1961-04-24 CH CH478961A patent/CH406229A/en unknown
- 1961-04-25 SE SE4323/61A patent/SE305876B/xx unknown
- 1961-04-26 GB GB15169/61A patent/GB988616A/en not_active Expired
- 1961-04-26 BE BE603078A patent/BE603078A/en unknown
- 1961-07-25 FR FR868991A patent/FR1327M/en active Active
-
1965
- 1965-12-30 NL NL6517177A patent/NL6517177A/xx unknown
-
1967
- 1967-02-13 OA OA52756A patent/OA02570A/en unknown
Also Published As
Publication number | Publication date |
---|---|
FR1327M (en) | 1962-05-28 |
BE603078A (en) | 1961-10-26 |
NL6517177A (en) | 1966-03-25 |
OA02570A (en) | 1970-05-05 |
SE305876B (en) | 1968-11-11 |
CH406229A (en) | 1966-01-31 |
NL125249C (en) |
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