GB983065A - Novel anticoagulant compositions - Google Patents

Novel anticoagulant compositions

Info

Publication number
GB983065A
GB983065A GB1256462A GB1256462A GB983065A GB 983065 A GB983065 A GB 983065A GB 1256462 A GB1256462 A GB 1256462A GB 1256462 A GB1256462 A GB 1256462A GB 983065 A GB983065 A GB 983065A
Authority
GB
United Kingdom
Prior art keywords
salt
silicacious
betaine
choline
morpholine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1256462A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mundipharma AG
Original Assignee
Mundipharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mundipharma AG filed Critical Mundipharma AG
Publication of GB983065A publication Critical patent/GB983065A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/42—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4
    • C07D311/44—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms in positions 2 and 4 with one hydrogen atom in position 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises a salt of the structural formula RA wherein R represents warfarin or 3,31 - methylenebis - (4 - hydroxycoumarin), and A is a radical selected from morpholine, choline, betaine and piperazine, and the preparation thereof by dissolving the said coumarin moiety and the said amine in an inert medium and evaporating said inert solvent to recover the residue. As inert medium there may be used alkanols having 1-6 carbon atoms, water and mixtures thereof.ALSO:The invention comprises a pharmaceutical composition comprising a pharmaceutical carrier and the silicacious adsorbed complex in which the adsorbate is a salt of the structural formula RA, wherein R represents warfarin or 3,31-methylene bis-(hydroxycoumarin) and A is an alkaline group selected from potassium, sodium, lithium, magnesium, calcium, choline, betaine, morpholine and piperazine, the adsorbent is a neutralized silicacious substance selected from the group consisting of fumed silicon dioxide, kaolin, and silica aerogel, having a particle size of from 0,01 to 0,20 microns, and a process for the preparation thereof by dissolving said salt RA in an inert solvent selected from alkanols having 1-6 carbon atoms, water, and mixtures of the same, adding the resulting solution to a dry granulation of a neutralized silicacious compound as described above, and recovering the residue by evaporating the solvent. Said compositions, which have anti-coagulant activity, are administered orally in tablets or capsules or parenterally either intramuscularly or intravenously. The invention also comprises a rodenticidal composition comprising a carrier and a salt of the formula RA wherein R is as defined above and A is a compound selected from choline, morpholine, betaine and piperazine. As carrier there may be used an edible substance, the salt RA being present in a concentration of from 0,01 to 0,1% by weight.
GB1256462A 1961-04-07 1962-04-02 Novel anticoagulant compositions Expired GB983065A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11248061A 1961-04-07 1961-04-07
US14485961A 1961-10-13 1961-10-13

Publications (1)

Publication Number Publication Date
GB983065A true GB983065A (en) 1965-02-10

Family

ID=26809999

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1256462A Expired GB983065A (en) 1961-04-07 1962-04-02 Novel anticoagulant compositions

Country Status (1)

Country Link
GB (1) GB983065A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201600093280A1 (en) * 2016-09-16 2018-03-16 Dr Tezza S R L RODENTICIDA IN DEGRADABLE ECO-FRIENDLY FORMULATIONS
WO2022037982A1 (en) * 2020-08-18 2022-02-24 The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin Pharmaceutical compositions comprising ionic liquids

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201600093280A1 (en) * 2016-09-16 2018-03-16 Dr Tezza S R L RODENTICIDA IN DEGRADABLE ECO-FRIENDLY FORMULATIONS
EP3295793A1 (en) * 2016-09-16 2018-03-21 Dr. Tezza S.r.l. Environmentally compatible degradable rodenticide formulations
WO2022037982A1 (en) * 2020-08-18 2022-02-24 The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin Pharmaceutical compositions comprising ionic liquids

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