GB964545A - Improvements in or relating to the treatment and preservation of animal tissue - Google Patents

Improvements in or relating to the treatment and preservation of animal tissue

Info

Publication number
GB964545A
GB964545A GB8569/62A GB856962A GB964545A GB 964545 A GB964545 A GB 964545A GB 8569/62 A GB8569/62 A GB 8569/62A GB 856962 A GB856962 A GB 856962A GB 964545 A GB964545 A GB 964545A
Authority
GB
United Kingdom
Prior art keywords
bone
extracted
washed
surfactant solution
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8569/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olin Corp
Original Assignee
Olin Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olin Corp filed Critical Olin Corp
Publication of GB964545A publication Critical patent/GB964545A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Dentistry (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Botany (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Animal tissue is extratced with a non-ionic surfactant solution, is extracted with a fat solvent, is extracted with a non-ionic surfactant solution and is then washed with water; it is stated that the thus-treated tissue is more likely to be compatible with a tissue to which it is subsequently grafted and is far easier to store for long periods. In a preferred procedure, animal bone is exercized under sanitary conditions, the bone is soaked in a sterilising solution of about 0.5 to 5.0% salt concentration, the bone is extracted with an aqueous surfactant solution containing about 0.5 to 2.0% of a pastial ester of a higher unsaturated fatty acid with an anhydride of a polyhydroxy alcohol surfactant, the bone is extracted with chleroform-methanol solution for about 20 to 30 hours, the bone is extracted with a further non-ionic aqueous surfactant solution, the bone is washed with continuously changing water for about 48 to 200 hours, and the washed bone is sterilized and then byophilized. Animal tissue includes bone, cartilage, tendon or fascia. Fat solvents: chloroform, acetone, lower aliphatic alcohols such as methanols or mixtures of these. Surfactants: partial esters of higher unsaturated fatty acids with anhydrides of polyhydroxy alcohols and polyoxyethylene derivatives thereof, particularly sorbitan mono-oleate polyoxyethylene and specified proprietary products. For sterilisation there may be employed inter alia solutions containing, liquid b -propiolactone, or cathode irradiation. Examples disclose detailed procedures.
GB8569/62A 1961-03-15 1962-03-06 Improvements in or relating to the treatment and preservation of animal tissue Expired GB964545A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9581161A 1961-03-15 1961-03-15
US16692562A 1962-01-17 1962-01-17

Publications (1)

Publication Number Publication Date
GB964545A true GB964545A (en) 1964-07-22

Family

ID=26790642

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8569/62A Expired GB964545A (en) 1961-03-15 1962-03-06 Improvements in or relating to the treatment and preservation of animal tissue

Country Status (4)

Country Link
CH (1) CH445016A (en)
ES (1) ES275477A1 (en)
GB (1) GB964545A (en)
NL (1) NL275983A (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3400199A (en) * 1965-02-26 1968-09-03 Leslie L. Balassa Wound-healing cartilage powder
WO1993012731A1 (en) * 1991-12-31 1993-07-08 Cryolife, Inc. Preparation of bone for transplantation
US5397353A (en) * 1984-05-24 1995-03-14 Oliver; Roy F. Implant tissue
US5513662A (en) * 1991-12-31 1996-05-07 Osteotech, Inc. Preparation of bone for transplantation
US5556379A (en) * 1994-08-19 1996-09-17 Lifenet Research Foundation Process for cleaning large bone grafts and bone grafts produced thereby
US5797871A (en) * 1994-08-19 1998-08-25 Lifenet Research Foundation Ultrasonic cleaning of allograft bone
US5976104A (en) * 1994-08-19 1999-11-02 Lifenet Research Foundation Recirculation method for cleaning essentially intact bone grafts using pressure mediated flow of solutions and bone grafts produced thereby
US5977034A (en) * 1994-08-19 1999-11-02 Lifenet Research Foundation Composition for cleaning bones
EP1530419A1 (en) * 2002-08-23 2005-05-18 Musculoskeletal Transplant Foundation Allograft tissue purification process for cleaning bone
EP1911418A1 (en) * 2005-07-29 2008-04-16 Summit (GD) Biotech Co., Ltd. Biological artificial ligament and preparation method thereof

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3400199A (en) * 1965-02-26 1968-09-03 Leslie L. Balassa Wound-healing cartilage powder
US5397353A (en) * 1984-05-24 1995-03-14 Oliver; Roy F. Implant tissue
WO1993012731A1 (en) * 1991-12-31 1993-07-08 Cryolife, Inc. Preparation of bone for transplantation
US5333626A (en) * 1991-12-31 1994-08-02 Cryolife, Inc. Preparation of bone for transplantation
US5513662A (en) * 1991-12-31 1996-05-07 Osteotech, Inc. Preparation of bone for transplantation
US5976104A (en) * 1994-08-19 1999-11-02 Lifenet Research Foundation Recirculation method for cleaning essentially intact bone grafts using pressure mediated flow of solutions and bone grafts produced thereby
US5797871A (en) * 1994-08-19 1998-08-25 Lifenet Research Foundation Ultrasonic cleaning of allograft bone
US5820581A (en) * 1994-08-19 1998-10-13 Lifenet Research Foundation Process for cleaning large bone grafts and bone grafts produced thereby
US5556379A (en) * 1994-08-19 1996-09-17 Lifenet Research Foundation Process for cleaning large bone grafts and bone grafts produced thereby
US5977034A (en) * 1994-08-19 1999-11-02 Lifenet Research Foundation Composition for cleaning bones
EP1530419A1 (en) * 2002-08-23 2005-05-18 Musculoskeletal Transplant Foundation Allograft tissue purification process for cleaning bone
EP1530419A4 (en) * 2002-08-23 2007-09-05 Musculoskeletal Transplant Allograft tissue purification process for cleaning bone
EP1929862A1 (en) * 2002-08-23 2008-06-11 Musculoskeletal Transplant Foundation Allograft tissue purification process for cleaning bone
EP1911418A1 (en) * 2005-07-29 2008-04-16 Summit (GD) Biotech Co., Ltd. Biological artificial ligament and preparation method thereof
EP1911418A4 (en) * 2005-07-29 2008-10-15 Summit Gd Biotech Co Ltd Biological artificial ligament and preparation method thereof
AU2006274361B2 (en) * 2005-07-29 2012-06-14 Summit (Gd) Biotech Co., Ltd Biological artificial ligament and preparation method thereof

Also Published As

Publication number Publication date
NL275983A (en) 1900-01-01
ES275477A1 (en) 1962-07-16
CH445016A (en) 1967-10-15

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