ES275477A1 - Improvements in or relating to the treatment and preservation of animal tissue - Google Patents

Improvements in or relating to the treatment and preservation of animal tissue

Info

Publication number
ES275477A1
ES275477A1 ES0275477A ES275477A ES275477A1 ES 275477 A1 ES275477 A1 ES 275477A1 ES 0275477 A ES0275477 A ES 0275477A ES 275477 A ES275477 A ES 275477A ES 275477 A1 ES275477 A1 ES 275477A1
Authority
ES
Spain
Prior art keywords
bone
extracted
washed
surfactant solution
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0275477A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Olin Corp
Original Assignee
Olin Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olin Corp filed Critical Olin Corp
Publication of ES275477A1 publication Critical patent/ES275477A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Dentistry (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Botany (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Animal tissue is extratced with a non-ionic surfactant solution, is extracted with a fat solvent, is extracted with a non-ionic surfactant solution and is then washed with water it is stated that the thus-treated tissue is more likely to be compatible with a tissue to which it is subsequently grafted and is far easier to store for long periods. In a preferred procedure, animal bone is exercized under sanitary conditions, the bone is soaked in a sterilising solution of about 0.5 to 5.0% salt concentration, the bone is extracted with an aqueous surfactant solution containing about 0.5 to 2.0% of a pastial ester of a higher unsaturated fatty acid with an anhydride of a polyhydroxy alcohol surfactant, the bone is extracted with chleroform-methanol solution for about 20 to 30 hours, the bone is extracted with a further non-ionic aqueous surfactant solution, the bone is washed with continuously changing water for about 48 to 200 hours, and the washed bone is sterilized and then byophilized. Animal tissue includes bone, cartilage, tendon or fascia. Fat solvents: chloroform, acetone, lower aliphatic alcohols such as methanols or mixtures of these. Surfactants: partial esters of higher unsaturated fatty acids with anhydrides of polyhydroxy alcohols and polyoxyethylene derivatives thereof, particularly sorbitan mono-oleate polyoxyethylene and specified proprietary products. For sterilisation there may be employed inter alia solutions containing, liquid b -propiolactone, or cathode irradiation. Examples disclose detailed procedures.
ES0275477A 1961-03-15 1962-03-14 Improvements in or relating to the treatment and preservation of animal tissue Expired ES275477A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9581161A 1961-03-15 1961-03-15
US16692562A 1962-01-17 1962-01-17

Publications (1)

Publication Number Publication Date
ES275477A1 true ES275477A1 (en) 1962-07-16

Family

ID=26790642

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0275477A Expired ES275477A1 (en) 1961-03-15 1962-03-14 Improvements in or relating to the treatment and preservation of animal tissue

Country Status (4)

Country Link
CH (1) CH445016A (en)
ES (1) ES275477A1 (en)
GB (1) GB964545A (en)
NL (1) NL275983A (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3400199A (en) * 1965-02-26 1968-09-03 Leslie L. Balassa Wound-healing cartilage powder
GB8413319D0 (en) * 1984-05-24 1984-06-27 Oliver Roy Frederick Biological material
US5513662A (en) * 1991-12-31 1996-05-07 Osteotech, Inc. Preparation of bone for transplantation
US5333626A (en) * 1991-12-31 1994-08-02 Cryolife, Inc. Preparation of bone for transplantation
US5976104A (en) * 1994-08-19 1999-11-02 Lifenet Research Foundation Recirculation method for cleaning essentially intact bone grafts using pressure mediated flow of solutions and bone grafts produced thereby
US5556379A (en) * 1994-08-19 1996-09-17 Lifenet Research Foundation Process for cleaning large bone grafts and bone grafts produced thereby
US5977034A (en) * 1994-08-19 1999-11-02 Lifenet Research Foundation Composition for cleaning bones
US5797871A (en) * 1994-08-19 1998-08-25 Lifenet Research Foundation Ultrasonic cleaning of allograft bone
US20040037735A1 (en) * 2002-08-23 2004-02-26 Depaula Carl Alexander Allograft tissue purification process for cleaning bone
CN1903144A (en) * 2005-07-29 2007-01-31 广东冠昊生物科技有限公司 Biological artificial ligamentum and method for preparing same

Also Published As

Publication number Publication date
NL275983A (en) 1900-01-01
CH445016A (en) 1967-10-15
GB964545A (en) 1964-07-22

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