GB959868A - An amino-ketone and salts thereof - Google Patents
An amino-ketone and salts thereofInfo
- Publication number
- GB959868A GB959868A GB31007/62A GB3100762A GB959868A GB 959868 A GB959868 A GB 959868A GB 31007/62 A GB31007/62 A GB 31007/62A GB 3100762 A GB3100762 A GB 3100762A GB 959868 A GB959868 A GB 959868A
- Authority
- GB
- United Kingdom
- Prior art keywords
- cyclohexyl
- ketone
- oxo
- propane
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises optically active or racemic 1-cyclohexyl -2- amino-propanone-(1) and acid addition salts thereof; and their preparation by (1) aminating a -bromo- or a -chloro-ethyl cyclohexyl ketone (prepared either by reacting cyclohexane with an a -halo-propionyl halide or by halogenating ethyl cyclohexyl ketone, the last-named being prepared either from a propionyl halide and cyclohexane or by a Grignard reaction on cyclohexane nitrile followed by hydrogenation); or (2) reacting cyclohexyl ethyl ketone with an alkyl nitrite and reducing the 1-cyclohexyl -1- oxo -2- isonitroso-propane formed; and, if desired, converting the product to an acid addition salt or resolving it into its optical isomers, for example by fractional crystallization of a salt with an optically active acid. Process (1) may be conducted either by aminating with an alkali metal phthalimide and hydrolysing the 1-cyclohexyl -1- oxo-2-phthalimido-propane formed (the hydrolysis preferably being conducted in two stages via the intermediate 1-cyclohexyl -1- oxo -2- phthaloylamido-propane) or by reacting with mono- or dibenzylamine and hydrogenating the 1-cyclohexyl-1-oxo-2-mono-or di-benzylamino-propane (or salt thereof) formed. Examples are given, and a list of salt-forming inorganic and organic acids is provided. The amino-ketone of the invention, which is stated to have appetite-reducing properties, may be made up into pharmaceutical compositions in admixture with suitable carriers. Tablets, capsules and ampoules are described, and suspensions emulsions and powders are referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEB63715A DE1159431B (en) | 1961-08-18 | 1961-08-18 | Process for the preparation of 1-cyclohexyl-2-aminopropanone- (1) and its salts |
Publications (1)
Publication Number | Publication Date |
---|---|
GB959868A true GB959868A (en) | 1964-06-03 |
Family
ID=6974111
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB31007/62A Expired GB959868A (en) | 1961-08-18 | 1962-08-13 | An amino-ketone and salts thereof |
Country Status (3)
Country | Link |
---|---|
DE (1) | DE1159431B (en) |
FR (1) | FR2056M (en) |
GB (1) | GB959868A (en) |
-
1961
- 1961-08-18 DE DEB63715A patent/DE1159431B/en active Pending
-
1962
- 1962-08-13 GB GB31007/62A patent/GB959868A/en not_active Expired
- 1962-08-16 FR FR907076A patent/FR2056M/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
FR2056M (en) | 1963-10-07 |
DE1159431B (en) | 1963-12-19 |
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