GB959868A - An amino-ketone and salts thereof - Google Patents

An amino-ketone and salts thereof

Info

Publication number
GB959868A
GB959868A GB31007/62A GB3100762A GB959868A GB 959868 A GB959868 A GB 959868A GB 31007/62 A GB31007/62 A GB 31007/62A GB 3100762 A GB3100762 A GB 3100762A GB 959868 A GB959868 A GB 959868A
Authority
GB
United Kingdom
Prior art keywords
cyclohexyl
ketone
oxo
propane
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB31007/62A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Boehringer Ingelheim GmbH
Original Assignee
CH Boehringer Sohn AG and Co KG
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG, Boehringer Ingelheim GmbH filed Critical CH Boehringer Sohn AG and Co KG
Publication of GB959868A publication Critical patent/GB959868A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises optically active or racemic 1-cyclohexyl -2- amino-propanone-(1) and acid addition salts thereof; and their preparation by (1) aminating a -bromo- or a -chloro-ethyl cyclohexyl ketone (prepared either by reacting cyclohexane with an a -halo-propionyl halide or by halogenating ethyl cyclohexyl ketone, the last-named being prepared either from a propionyl halide and cyclohexane or by a Grignard reaction on cyclohexane nitrile followed by hydrogenation); or (2) reacting cyclohexyl ethyl ketone with an alkyl nitrite and reducing the 1-cyclohexyl -1- oxo -2- isonitroso-propane formed; and, if desired, converting the product to an acid addition salt or resolving it into its optical isomers, for example by fractional crystallization of a salt with an optically active acid. Process (1) may be conducted either by aminating with an alkali metal phthalimide and hydrolysing the 1-cyclohexyl -1- oxo-2-phthalimido-propane formed (the hydrolysis preferably being conducted in two stages via the intermediate 1-cyclohexyl -1- oxo -2- phthaloylamido-propane) or by reacting with mono- or dibenzylamine and hydrogenating the 1-cyclohexyl-1-oxo-2-mono-or di-benzylamino-propane (or salt thereof) formed. Examples are given, and a list of salt-forming inorganic and organic acids is provided. The amino-ketone of the invention, which is stated to have appetite-reducing properties, may be made up into pharmaceutical compositions in admixture with suitable carriers. Tablets, capsules and ampoules are described, and suspensions emulsions and powders are referred to.
GB31007/62A 1961-08-18 1962-08-13 An amino-ketone and salts thereof Expired GB959868A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEB63715A DE1159431B (en) 1961-08-18 1961-08-18 Process for the preparation of 1-cyclohexyl-2-aminopropanone- (1) and its salts

Publications (1)

Publication Number Publication Date
GB959868A true GB959868A (en) 1964-06-03

Family

ID=6974111

Family Applications (1)

Application Number Title Priority Date Filing Date
GB31007/62A Expired GB959868A (en) 1961-08-18 1962-08-13 An amino-ketone and salts thereof

Country Status (3)

Country Link
DE (1) DE1159431B (en)
FR (1) FR2056M (en)
GB (1) GB959868A (en)

Also Published As

Publication number Publication date
FR2056M (en) 1963-10-07
DE1159431B (en) 1963-12-19

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