GB959853A - Penicillins - Google Patents
PenicillinsInfo
- Publication number
- GB959853A GB959853A GB775162A GB775162A GB959853A GB 959853 A GB959853 A GB 959853A GB 775162 A GB775162 A GB 775162A GB 775162 A GB775162 A GB 775162A GB 959853 A GB959853 A GB 959853A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- general formula
- aminopenicillanic
- aryl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930182555 Penicillin Natural products 0.000 title abstract 2
- 150000002960 penicillins Chemical class 0.000 title abstract 2
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 5
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 239000004470 DL Methionine Substances 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical class CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- NTCCNERMXRIPTR-UHFFFAOYSA-N 2-hydroxy-1-naphthaldehyde Chemical compound C1=CC=CC2=C(C=O)C(O)=CC=C21 NTCCNERMXRIPTR-UHFFFAOYSA-N 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical class [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000008065 acid anhydrides Chemical class 0.000 abstract 1
- 238000006136 alcoholysis reaction Methods 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 150000008064 anhydrides Chemical class 0.000 abstract 1
- 150000001718 carbodiimides Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- FFEARJCKVFRZRR-UHFFFAOYSA-N methionine Chemical compound CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 abstract 1
- 229930182817 methionine Natural products 0.000 abstract 1
- 235000006109 methionine Nutrition 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
- C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
- C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
- C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Lubricants (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB775162A GB959853A (en) | 1962-02-28 | 1962-02-28 | Penicillins |
| NO00147431A NO129956B (enrdf_load_stackoverflow) | 1962-02-28 | 1963-02-06 | |
| BR14679563A BR6346795D0 (pt) | 1962-02-28 | 1963-02-08 | Processo para a preparacao de penicilinas sililicas e produtos resultantes |
| ES285236A ES285236A1 (es) | 1962-02-28 | 1963-02-18 | Procedimiento para la preparación de penicilinas |
| CH213663A CH446336A (de) | 1962-02-28 | 1963-02-20 | Verfahren zur Herstellung von Penicillinen |
| SE197763A SE320369B (enrdf_load_stackoverflow) | 1962-02-28 | 1963-02-22 | |
| AT139563A AT275732B (de) | 1962-02-28 | 1963-02-22 | Verfahren zur Herstellung von Penicillinen |
| FI37563A FI41652C (fi) | 1962-02-28 | 1963-02-26 | Menetelmä penisilliinien ja niiden myrkyttömien suolojen valmistamiseksi |
| DK92263A DK132412C (da) | 1962-02-28 | 1963-02-28 | Fremgangsmade til fremstilling af alfa-aminosubstituerede penicilliner eller salte deraf |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB775262 | 1962-02-28 | ||
| GB775162A GB959853A (en) | 1962-02-28 | 1962-02-28 | Penicillins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB959853A true GB959853A (en) | 1964-06-03 |
Family
ID=26241643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB775162A Expired GB959853A (en) | 1962-02-28 | 1962-02-28 | Penicillins |
Country Status (9)
| Country | Link |
|---|---|
| AT (1) | AT275732B (enrdf_load_stackoverflow) |
| BR (1) | BR6346795D0 (enrdf_load_stackoverflow) |
| CH (1) | CH446336A (enrdf_load_stackoverflow) |
| DK (1) | DK132412C (enrdf_load_stackoverflow) |
| ES (1) | ES285236A1 (enrdf_load_stackoverflow) |
| FI (1) | FI41652C (enrdf_load_stackoverflow) |
| GB (1) | GB959853A (enrdf_load_stackoverflow) |
| NO (1) | NO129956B (enrdf_load_stackoverflow) |
| SE (1) | SE320369B (enrdf_load_stackoverflow) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3678037A (en) * | 1970-08-10 | 1972-07-18 | American Home Prod | Process for producing {60 -amino penicillin intermediates |
| US3846407A (en) * | 1970-07-03 | 1974-11-05 | Chinoin Gyogyszer Es Vegyeszet | Penicillin derivatives containing a halogeno-carbonyl group |
| US4182709A (en) * | 1976-01-15 | 1980-01-08 | Glaxo Group Limited | Manufacture of semi-synthetic penicillin antibiotics |
| US4278600A (en) | 1979-03-19 | 1981-07-14 | Bristol-Myers Company | Production of penicillins |
| US4310458A (en) | 1979-03-19 | 1982-01-12 | Bristol-Myers Company | Production of penicillins |
| US7230097B2 (en) | 2003-03-10 | 2007-06-12 | Lupin Ltd. | Process for preparation of 7-[α-Amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid |
-
1962
- 1962-02-28 GB GB775162A patent/GB959853A/en not_active Expired
-
1963
- 1963-02-06 NO NO00147431A patent/NO129956B/no unknown
- 1963-02-08 BR BR14679563A patent/BR6346795D0/pt unknown
- 1963-02-18 ES ES285236A patent/ES285236A1/es not_active Expired
- 1963-02-20 CH CH213663A patent/CH446336A/de unknown
- 1963-02-22 SE SE197763A patent/SE320369B/xx unknown
- 1963-02-22 AT AT139563A patent/AT275732B/de active
- 1963-02-26 FI FI37563A patent/FI41652C/fi active
- 1963-02-28 DK DK92263A patent/DK132412C/da active
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3846407A (en) * | 1970-07-03 | 1974-11-05 | Chinoin Gyogyszer Es Vegyeszet | Penicillin derivatives containing a halogeno-carbonyl group |
| US3678037A (en) * | 1970-08-10 | 1972-07-18 | American Home Prod | Process for producing {60 -amino penicillin intermediates |
| US4182709A (en) * | 1976-01-15 | 1980-01-08 | Glaxo Group Limited | Manufacture of semi-synthetic penicillin antibiotics |
| US4278600A (en) | 1979-03-19 | 1981-07-14 | Bristol-Myers Company | Production of penicillins |
| US4310458A (en) | 1979-03-19 | 1982-01-12 | Bristol-Myers Company | Production of penicillins |
| US7230097B2 (en) | 2003-03-10 | 2007-06-12 | Lupin Ltd. | Process for preparation of 7-[α-Amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid |
| US7427692B2 (en) | 2003-03-10 | 2008-09-23 | Lupin Ltd. | Process for preparation of 7-[α-amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid |
Also Published As
| Publication number | Publication date |
|---|---|
| NO129956B (enrdf_load_stackoverflow) | 1974-06-17 |
| ES285236A1 (es) | 1963-06-01 |
| DK132412C (da) | 1976-05-03 |
| SE320369B (enrdf_load_stackoverflow) | 1970-02-09 |
| FI41652C (fi) | 1973-03-23 |
| BR6346795D0 (pt) | 1973-07-19 |
| CH446336A (de) | 1967-11-15 |
| AT275732B (de) | 1969-11-10 |
| DK132412B (da) | 1975-12-01 |
| FI41652B (enrdf_load_stackoverflow) | 1969-09-30 |
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