GB959378A - 21-substituted 17ª, 21-dioxy steroids and processes for their preparation - Google Patents
21-substituted 17ª, 21-dioxy steroids and processes for their preparationInfo
- Publication number
- GB959378A GB959378A GB15754/63A GB1575463A GB959378A GB 959378 A GB959378 A GB 959378A GB 15754/63 A GB15754/63 A GB 15754/63A GB 1575463 A GB1575463 A GB 1575463A GB 959378 A GB959378 A GB 959378A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- positions
- halogen
- dione
- acetate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003431 steroids Chemical class 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 230000003301 hydrolyzing effect Effects 0.000 abstract 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- JRNVZBWKYDBUCA-UHFFFAOYSA-N N-chlorosuccinimide Chemical compound ClN1C(=O)CCC1=O JRNVZBWKYDBUCA-UHFFFAOYSA-N 0.000 abstract 2
- 230000000397 acetylating effect Effects 0.000 abstract 2
- 125000001118 alkylidene group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000006071 cream Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 229960004584 methylprednisolone Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002674 ointment Substances 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 229960005205 prednisolone Drugs 0.000 abstract 1
- -1 steroid compounds Chemical class 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84559459A | 1959-10-12 | 1959-10-12 | |
| US84559559A | 1959-10-12 | 1959-10-12 | |
| US84566159A | 1959-10-12 | 1959-10-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB959378A true GB959378A (en) | 1964-06-03 |
Family
ID=27420319
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB15754/63A Expired GB959378A (en) | 1959-10-12 | 1960-09-13 | 21-substituted 17ª, 21-dioxy steroids and processes for their preparation |
| GB31484/60A Expired GB959377A (en) | 1959-10-12 | 1960-09-13 | Dioxy steroids and processes for their preparation |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB31484/60A Expired GB959377A (en) | 1959-10-12 | 1960-09-13 | Dioxy steroids and processes for their preparation |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE595971A (enrdf_load_stackoverflow) |
| CH (1) | CH392500A (enrdf_load_stackoverflow) |
| DE (1) | DE1188079B (enrdf_load_stackoverflow) |
| DK (1) | DK108281C (enrdf_load_stackoverflow) |
| FR (2) | FR1428454A (enrdf_load_stackoverflow) |
| GB (2) | GB959378A (enrdf_load_stackoverflow) |
| NL (1) | NL6810178A (enrdf_load_stackoverflow) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8207151B2 (en) | 2008-05-28 | 2012-06-26 | Validus Biopharma Inc. | Non-hormonal steroid modulators of NF-κB for treatment of disease |
| US9198921B2 (en) | 2010-04-05 | 2015-12-01 | Reveragen Biopharma, Inc. | Non-hormonal steroid modulators of NF-κB for treatment of disease |
| US10799514B2 (en) | 2015-06-29 | 2020-10-13 | Reveragen Biopharma, Inc. | Non-hormonal steroid modulators of NF-kappa beta for treatment of disease |
| US11382922B2 (en) | 2019-03-07 | 2022-07-12 | Reveragen Biopharma, Inc. | Aqueous oral pharmaceutical suspension compositions |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4069322A (en) * | 1976-10-12 | 1978-01-17 | Interx Research Corporation | Pro-drugs for the improved delivery of certain selected anti-inflammatory steroids |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2866799A (en) * | 1957-01-02 | 1958-12-30 | Merck & Co Inc | Method for converting a 17-20, 20-21 bismethylenedioxy or a 17-20, 20-21 bis-substituted methylenedioxy steroid of the pregnane series to a 17alpha, 21-dihydroxy-20-ketosteroid of the pregnane series |
-
1960
- 1960-09-13 GB GB15754/63A patent/GB959378A/en not_active Expired
- 1960-09-13 GB GB31484/60A patent/GB959377A/en not_active Expired
- 1960-10-01 DE DESCH28561A patent/DE1188079B/de active Pending
- 1960-10-08 CH CH1132160A patent/CH392500A/de unknown
- 1960-10-11 DK DK115064AA patent/DK108281C/da active
- 1960-10-12 BE BE595971A patent/BE595971A/fr unknown
- 1960-10-12 FR FR840981A patent/FR1428454A/fr not_active Expired
-
1961
- 1961-01-06 FR FR849005A patent/FR957M/fr active Active
-
1968
- 1968-07-18 NL NL6810178A patent/NL6810178A/xx unknown
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10857161B2 (en) | 2008-05-28 | 2020-12-08 | Reveragen Biopharma, Inc. | Non-hormonal steroid modulators of NF-kB for treatment of disease |
| US8334279B2 (en) | 2008-05-28 | 2012-12-18 | Validus Genetics | Non-hormonal steroid modulators of NF-κB for treatment of disease |
| US8673887B2 (en) | 2008-05-28 | 2014-03-18 | Reveragen Biopharma, Inc | Non-hormonal steroid modulators of NF-kB for treatment of disease |
| US8207151B2 (en) | 2008-05-28 | 2012-06-26 | Validus Biopharma Inc. | Non-hormonal steroid modulators of NF-κB for treatment of disease |
| US9434758B2 (en) | 2008-05-28 | 2016-09-06 | Reveragen Biopharma, Inc. | Non-hormonal steroid modulators of NF-κB for treatment of disease |
| US9649320B2 (en) | 2008-05-28 | 2017-05-16 | Reveragen Biopharma, Inc. | Non-hormonal steroid modulators of NF-κB for treatment of disease |
| US11833159B2 (en) | 2008-05-28 | 2023-12-05 | Reveragen Biopharma, Inc. | Non-hormonal steroid modulators of NF-kB for treatment of disease |
| US10206933B2 (en) | 2008-05-28 | 2019-02-19 | Reveragen Biopharma, Inc. | Non-hormonal steroid modulators of NF-kB for treatment of disease |
| US9198921B2 (en) | 2010-04-05 | 2015-12-01 | Reveragen Biopharma, Inc. | Non-hormonal steroid modulators of NF-κB for treatment of disease |
| US10000525B2 (en) | 2010-04-05 | 2018-06-19 | Reveragen Biopharma, Inc. | Non-hormonal steroid modulators of NF-κB for treatment of disease |
| US10799514B2 (en) | 2015-06-29 | 2020-10-13 | Reveragen Biopharma, Inc. | Non-hormonal steroid modulators of NF-kappa beta for treatment of disease |
| US11690853B2 (en) | 2015-06-29 | 2023-07-04 | Reveragen Biopharma, Inc. | Non-hormonal steroid modulators of NF-κβ for treatment of disease |
| US11382922B2 (en) | 2019-03-07 | 2022-07-12 | Reveragen Biopharma, Inc. | Aqueous oral pharmaceutical suspension compositions |
| US11471471B2 (en) | 2019-03-07 | 2022-10-18 | Reveragen Biopharma, Inc. | Aqueous oral pharmaceutical suspension compositions |
| US12201639B2 (en) | 2019-03-07 | 2025-01-21 | Reveragen Biopharma, Inc. | Aqueous oral pharmaceutical suspension compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| FR1428454A (fr) | 1966-02-18 |
| CH392500A (de) | 1965-05-31 |
| DK108281C (da) | 1967-11-06 |
| DE1188079B (de) | 1965-03-04 |
| FR957M (enrdf_load_stackoverflow) | 1961-11-27 |
| NL6810178A (enrdf_load_stackoverflow) | 1968-10-25 |
| GB959377A (en) | 1964-06-03 |
| BE595971A (fr) | 1961-02-01 |
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