GB957685A - Production of 6-aminopenicillanic acid - Google Patents
Production of 6-aminopenicillanic acidInfo
- Publication number
- GB957685A GB957685A GB2725161A GB2725161A GB957685A GB 957685 A GB957685 A GB 957685A GB 2725161 A GB2725161 A GB 2725161A GB 2725161 A GB2725161 A GB 2725161A GB 957685 A GB957685 A GB 957685A
- Authority
- GB
- United Kingdom
- Prior art keywords
- penicillin
- aminopenicillanic acid
- bacterium
- salt
- reaction mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D499/42—Compounds with a free primary amino radical attached in position 6
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
A continuous process for the manufacture of 6-aminopenicillanic acid comprises adding cells of a bacterium as specified below to a solution of a penicillin or a salt thereof, and, a suitable time after adding the cells, continuously or intermittently adding more of the solution of the penicillin or the salt thereof while simultaneously withdrawing a substantially equal volume of the reaction mixture, whereafter 6-aminopenicillanic acid is isolated by conventional means from the reaction mixture which has been withdrawn from the reactor vessel. The bacterium may be a member of the species Escherichia coli which produces suitable penicillin-splitting enzymes, a member of the species Alcaligenes faecalis, or a member of the genera Aerobacter, Proteus, Pseudomonas or Micrococcus.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2725161A GB957685A (en) | 1961-07-27 | 1961-07-27 | Production of 6-aminopenicillanic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2725161A GB957685A (en) | 1961-07-27 | 1961-07-27 | Production of 6-aminopenicillanic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB957685A true GB957685A (en) | 1964-05-13 |
Family
ID=10256550
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2725161A Expired GB957685A (en) | 1961-07-27 | 1961-07-27 | Production of 6-aminopenicillanic acid |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB957685A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0638649A2 (en) * | 1993-08-05 | 1995-02-15 | Gist-Brocades N.V. | New use of alcaligenes faecalis penicillin G acylase |
-
1961
- 1961-07-27 GB GB2725161A patent/GB957685A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0638649A2 (en) * | 1993-08-05 | 1995-02-15 | Gist-Brocades N.V. | New use of alcaligenes faecalis penicillin G acylase |
| EP0638649A3 (en) * | 1993-08-05 | 1995-03-15 | Gist-Brocades N.V. | New use of alcaligenes faecalis penicillin G acylase |
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