GB952193A - A process for the manufacture of steroid-21-orthophosphates and their salts - Google Patents
A process for the manufacture of steroid-21-orthophosphates and their saltsInfo
- Publication number
- GB952193A GB952193A GB40131/60A GB4013160A GB952193A GB 952193 A GB952193 A GB 952193A GB 40131/60 A GB40131/60 A GB 40131/60A GB 4013160 A GB4013160 A GB 4013160A GB 952193 A GB952193 A GB 952193A
- Authority
- GB
- United Kingdom
- Prior art keywords
- steroid
- reacting
- salts
- radicals
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 steroid radical Chemical class 0.000 abstract 4
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000003431 steroids Chemical class 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 229910019142 PO4 Inorganic materials 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 239000012445 acidic reagent Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 239000003513 alkali Substances 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 2
- 150000003254 radicals Chemical class 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 abstract 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 125000001118 alkylidene group Chemical group 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000003518 caustics Substances 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000006356 dehydrogenation reaction Methods 0.000 abstract 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 abstract 1
- CNTIXUGILVWVHR-UHFFFAOYSA-N diphosphoryl chloride Chemical compound ClP(Cl)(=O)OP(Cl)(Cl)=O CNTIXUGILVWVHR-UHFFFAOYSA-N 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 235000005985 organic acids Nutrition 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 150000003128 pregnanes Chemical class 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEM43500A DE1134075B (de) | 1959-11-26 | 1959-11-26 | Verfahren zur Herstellung von primaeren Steroid-21-orthophosphorsaeureestern und deren physiologisch vertraeglichen wasserloeslichen Salzen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB952193A true GB952193A (en) | 1964-03-11 |
Family
ID=7304682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB40131/60A Expired GB952193A (en) | 1959-11-26 | 1960-11-22 | A process for the manufacture of steroid-21-orthophosphates and their salts |
Country Status (5)
| Country | Link |
|---|---|
| BR (1) | BR6024268D0 (https=) |
| CH (1) | CH387031A (https=) |
| DE (1) | DE1134075B (https=) |
| GB (1) | GB952193A (https=) |
| SE (1) | SE220106C1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008139210A3 (en) * | 2007-05-16 | 2009-04-16 | Hovione Int Ltd | Process for obtaining steroidal phosphate compounds |
| CN114685595A (zh) * | 2020-12-30 | 2022-07-01 | 天津药业研究院股份有限公司 | 倍他米松磷酸酯二水合物及其制备方法和应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB805828A (en) * | 1954-08-04 | 1958-12-17 | Merck & Co Inc | Phosphate derivatives of steroids |
| US2779775A (en) * | 1954-09-30 | 1957-01-29 | Merck & Co Inc | Phosphate derivatives of 9alpha-fluorosteroids |
| DE1044810B (de) * | 1955-01-14 | 1958-11-27 | Merck & Co Inc | Verfahren zur Herstellung von 21-Phosphorsaeureestern von in 1, 4-Stellung ungesaettigten 3, 20-Diketo- und 3, 11, 20-Triketosteroiden |
-
1959
- 1959-11-26 DE DEM43500A patent/DE1134075B/de active Pending
-
1960
- 1960-10-10 CH CH1134460A patent/CH387031A/de unknown
- 1960-11-17 BR BR124268/60A patent/BR6024268D0/pt unknown
- 1960-11-22 GB GB40131/60A patent/GB952193A/en not_active Expired
- 1960-11-23 SE SE1131760A patent/SE220106C1/sl unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008139210A3 (en) * | 2007-05-16 | 2009-04-16 | Hovione Int Ltd | Process for obtaining steroidal phosphate compounds |
| US8445471B2 (en) | 2007-05-16 | 2013-05-21 | Hovione Inter Limited | Process for obtaining steroidal phosphate compounds |
| CN101742987B (zh) * | 2007-05-16 | 2015-07-22 | 霍维奥恩联合有限公司 | 用于得到甾体磷酸酯化合物的方法 |
| CN114685595A (zh) * | 2020-12-30 | 2022-07-01 | 天津药业研究院股份有限公司 | 倍他米松磷酸酯二水合物及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| SE220106C1 (https=) | 1968-04-23 |
| DE1134075B (de) | 1962-08-02 |
| CH387031A (de) | 1965-01-31 |
| BR6024268D0 (pt) | 1973-07-03 |
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