GB943041A - 1-methyl-oestratriene-derivatives and the preparation thereof - Google Patents
1-methyl-oestratriene-derivatives and the preparation thereofInfo
- Publication number
- GB943041A GB943041A GB7495/61A GB749561A GB943041A GB 943041 A GB943041 A GB 943041A GB 7495/61 A GB7495/61 A GB 7495/61A GB 749561 A GB749561 A GB 749561A GB 943041 A GB943041 A GB 943041A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- keto
- general formula
- hydroxy
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- -1 perchloric Substances 0.000 abstract 3
- 150000003431 steroids Chemical class 0.000 abstract 3
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000012467 final product Substances 0.000 abstract 2
- QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 abstract 2
- 125000000468 ketone group Chemical group 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 abstract 2
- 239000007818 Grignard reagent Substances 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000010306 acid treatment Methods 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 230000002402 anti-lipaemic effect Effects 0.000 abstract 1
- 150000001244 carboxylic acid anhydrides Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008298 dragée Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 abstract 1
- 150000004795 grignard reagents Chemical class 0.000 abstract 1
- 150000007857 hydrazones Chemical class 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 235000011149 sulphuric acid Nutrition 0.000 abstract 1
- 239000001117 sulphuric acid Substances 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
- 235000005074 zinc chloride Nutrition 0.000 abstract 1
- 239000011592 zinc chloride Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEM44627A DE1219933B (de) | 1960-03-11 | 1960-03-11 | Verfahren zur Herstellung von 1-Methyl-1, 3, 5(10)-oestratrien-derivaten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB943041A true GB943041A (en) | 1963-11-27 |
Family
ID=7305029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7495/61A Expired GB943041A (en) | 1960-03-11 | 1961-03-01 | 1-methyl-oestratriene-derivatives and the preparation thereof |
Country Status (6)
-
1960
- 1960-03-11 DE DEM44627A patent/DE1219933B/de active Pending
-
1961
- 1961-02-22 CH CH208861A patent/CH400148A/de unknown
- 1961-02-28 SE SE213561A patent/SE218981C1/sl unknown
- 1961-03-01 GB GB7495/61A patent/GB943041A/en not_active Expired
- 1961-03-10 FR FR855235A patent/FR1006M/fr active Active
- 1961-03-10 DK DK103861AA patent/DK107094C/da active
-
1964
- 1964-09-22 SE SE1137764A patent/SE303491B/xx unknown
- 1964-09-22 SE SE1137864A patent/SE303492B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE1219933B (de) | 1966-06-30 |
| CH400148A (de) | 1965-10-15 |
| SE303491B (sv) | 1968-09-02 |
| SE303492B (sv) | 1968-09-02 |
| FR1006M (fr) | 1961-12-18 |
| DK107094C (da) | 1967-04-24 |
| SE218981C1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1968-02-20 |
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