GB935601A - Delayed release preparations for asthma therapy containing theophylline - Google Patents
Delayed release preparations for asthma therapy containing theophyllineInfo
- Publication number
- GB935601A GB935601A GB17192/61A GB1719261A GB935601A GB 935601 A GB935601 A GB 935601A GB 17192/61 A GB17192/61 A GB 17192/61A GB 1719261 A GB1719261 A GB 1719261A GB 935601 A GB935601 A GB 935601A
- Authority
- GB
- United Kingdom
- Prior art keywords
- theophylline
- medicament
- pellets
- coating
- pellet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 title abstract 7
- 229960000278 theophylline Drugs 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 3
- 208000006673 asthma Diseases 0.000 title 1
- 230000003111 delayed effect Effects 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 239000008188 pellet Substances 0.000 abstract 9
- 239000011248 coating agent Substances 0.000 abstract 6
- 238000000576 coating method Methods 0.000 abstract 6
- 239000003814 drug Substances 0.000 abstract 6
- 239000000730 antalgic agent Substances 0.000 abstract 2
- 239000002221 antipyretic Substances 0.000 abstract 2
- 229940125716 antipyretic agent Drugs 0.000 abstract 2
- 239000003434 antitussive agent Substances 0.000 abstract 2
- 229940124584 antitussives Drugs 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- XQYZDYMELSJDRZ-UHFFFAOYSA-N papaverine Chemical compound C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 XQYZDYMELSJDRZ-UHFFFAOYSA-N 0.000 abstract 2
- AKNNEGZIBPJZJG-MSOLQXFVSA-N (-)-noscapine Chemical compound CN1CCC2=CC=3OCOC=3C(OC)=C2[C@@H]1[C@@H]1C2=CC=C(OC)C(OC)=C2C(=O)O1 AKNNEGZIBPJZJG-MSOLQXFVSA-N 0.000 abstract 1
- XYBFIZMXHHNHKG-UHFFFAOYSA-N 1,3-dimethyl-7h-purine-2,6-dione;2-(2-hydroxyethylamino)ethanol Chemical compound OCCNCCO.O=C1N(C)C(=O)N(C)C2=C1NC=N2 XYBFIZMXHHNHKG-UHFFFAOYSA-N 0.000 abstract 1
- NWPRCRWQMGIBOT-UHFFFAOYSA-N 7-(2-hydroxyethyl)-1,3-dimethylpurine-2,6-dione Chemical compound O=C1N(C)C(=O)N(C)C2=C1N(CCO)C=N2 NWPRCRWQMGIBOT-UHFFFAOYSA-N 0.000 abstract 1
- 229930008281 A03AD01 - Papaverine Natural products 0.000 abstract 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 abstract 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 abstract 1
- 241000246358 Thymus Species 0.000 abstract 1
- 235000007303 Thymus vulgaris Nutrition 0.000 abstract 1
- 229960001138 acetylsalicylic acid Drugs 0.000 abstract 1
- AKNNEGZIBPJZJG-UHFFFAOYSA-N alpha-noscapine Natural products CN1CCC2=CC=3OCOC=3C(OC)=C2C1C1C2=CC=C(OC)C(OC)=C2C(=O)O1 AKNNEGZIBPJZJG-UHFFFAOYSA-N 0.000 abstract 1
- FQPFAHBPWDRTLU-UHFFFAOYSA-N aminophylline Chemical compound NCCN.O=C1N(C)C(=O)N(C)C2=C1NC=N2.O=C1N(C)C(=O)N(C)C2=C1NC=N2 FQPFAHBPWDRTLU-UHFFFAOYSA-N 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 235000013871 bee wax Nutrition 0.000 abstract 1
- 239000012166 beeswax Substances 0.000 abstract 1
- HBGYWKVYHHULPL-UHFFFAOYSA-L calcium;1,3-dimethyl-7h-purine-2,6-dione;2-oxidobenzoate Chemical compound [Ca+2].[O-]C(=O)C1=CC=CC=C1[O-].O=C1N(C)C(=O)N(C)C2=C1NC=N2 HBGYWKVYHHULPL-UHFFFAOYSA-L 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- SOELXOBIIIBLRJ-UHFFFAOYSA-M choline theophyllinate Chemical compound C[N+](C)(C)CCO.CN1C(=O)N(C)C([O-])=C2N=CN=C21 SOELXOBIIIBLRJ-UHFFFAOYSA-M 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- KXRNMXPUTQVFOA-UHFFFAOYSA-L disodium;1,3-dimethyl-2-oxopurin-6-olate;acetate Chemical compound [Na+].[Na+].CC([O-])=O.CN1C(=O)N(C)C([O-])=C2N=CN=C21 KXRNMXPUTQVFOA-UHFFFAOYSA-L 0.000 abstract 1
- 150000002191 fatty alcohols Chemical class 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 230000037406 food intake Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 125000005456 glyceride group Chemical group 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- PLPRGLOFPNJOTN-UHFFFAOYSA-N narcotine Natural products COc1ccc2C(OC(=O)c2c1OC)C3Cc4c(CN3C)cc5OCOc5c4OC PLPRGLOFPNJOTN-UHFFFAOYSA-N 0.000 abstract 1
- 229960004708 noscapine Drugs 0.000 abstract 1
- 229960001789 papaverine Drugs 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229960004025 sodium salicylate Drugs 0.000 abstract 1
- QVGLHVDBDYLFON-UHFFFAOYSA-M sodium;1,3-dimethylpurin-7-ide-2,6-dione Chemical compound [Na+].O=C1N(C)C(=O)N(C)C2=C1[N-]C=N2 QVGLHVDBDYLFON-UHFFFAOYSA-M 0.000 abstract 1
- AIJQWRAOMFRHTQ-UHFFFAOYSA-M sodium;2-aminoacetate;1,3-dimethyl-7h-purine-2,6-dione Chemical compound [Na+].NCC([O-])=O.O=C1N(C)C(=O)N(C)C2=C1NC=N2 AIJQWRAOMFRHTQ-UHFFFAOYSA-M 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
- -1 theophylline compound Chemical class 0.000 abstract 1
- 229960005444 theophylline sodium glycinate Drugs 0.000 abstract 1
- 239000001585 thymus vulgaris Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85978A US3109775A (en) | 1961-01-31 | 1961-01-31 | Theophylline-noscapine sustained release composition for treatment of asthma |
| DEK0050632 | 1963-08-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB935601A true GB935601A (en) | 1963-08-28 |
Family
ID=25983781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB17192/61A Expired GB935601A (en) | 1961-01-31 | 1961-05-11 | Delayed release preparations for asthma therapy containing theophylline |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US3109775A (forum.php) |
| BE (1) | BE636568A (forum.php) |
| DE (1) | DE1467966A1 (forum.php) |
| GB (1) | GB935601A (forum.php) |
| NL (1) | NL297088A (forum.php) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2484253A1 (fr) * | 1980-05-06 | 1981-12-18 | Bristol Myers Co | Comprime de theophylline a liberation prolongee |
| GR880100297A (en) * | 1987-05-08 | 1989-02-23 | Orion Yhtymae Oy | A new synthesis / composition |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3432593A (en) * | 1963-09-18 | 1969-03-11 | Key Pharm Inc | Delayed and sustained release type pharmaceutical preparation |
| EP0083372B1 (en) * | 1981-07-15 | 1988-05-18 | Key Pharmaceuticals, Inc. | Sustained release theophyline |
| US4587118A (en) * | 1981-07-15 | 1986-05-06 | Key Pharmaceuticals, Inc. | Dry sustained release theophylline oral formulation |
| US4764380A (en) * | 1982-03-22 | 1988-08-16 | Alza Corporation | Drug delivery system comprising a volume increasing matrix containing a plurality of tiny pills |
| US4994260A (en) * | 1982-05-28 | 1991-02-19 | Astra Lakemedel Aktiebolag | Pharmaceutical mixture |
| SE8203953D0 (sv) * | 1982-06-24 | 1982-06-24 | Astra Laekemedel Ab | Pharmaceutical mixture |
| US4508702A (en) * | 1982-06-14 | 1985-04-02 | Key Pharmaceuticals, Inc. | Sustained release aspirin |
| US4503031A (en) * | 1982-12-17 | 1985-03-05 | Glassman Jacob A | Super-fast-starting-sustained release tablet |
| IE55745B1 (en) * | 1983-04-06 | 1991-01-02 | Elan Corp Plc | Sustained absorption pharmaceutical composition |
| US4555399A (en) * | 1983-11-18 | 1985-11-26 | Key Pharmaceuticals, Inc. | Aspirin tablet |
| US4876094A (en) * | 1984-01-13 | 1989-10-24 | Battelle Development Corporation | Controlled release liquid dosage formulation |
| US4837032A (en) * | 1986-02-04 | 1989-06-06 | Farval Ag | Theophylline sustained release tablet |
| IL78017A (en) * | 1986-03-03 | 1989-06-30 | Yissum Res Dev Co | Sustained release tablets of theophylline |
| US5019302A (en) * | 1986-03-12 | 1991-05-28 | Washington University Technology Associates, Inc. | Method for granulation |
| US5026709A (en) * | 1986-04-07 | 1991-06-25 | Rorer Pharmaceutical Corporation | Method for the preparation of a theophylline sustained release pharmaceutical composition and the composition prepared thereby |
| WO1987006098A1 (en) * | 1986-04-07 | 1987-10-22 | Rorer International (Overseas) Inc. | Method for the preparation of a sustained release pharmaceutical composition and the composition prepared thereby |
| US4851232A (en) * | 1987-02-13 | 1989-07-25 | Alza Corporation | Drug delivery system with means for obtaining desirable in vivo release rate pattern |
| US4853229A (en) * | 1987-10-26 | 1989-08-01 | Alza Corporation | Method for adminstering tiny pills |
| US4961932A (en) * | 1987-10-26 | 1990-10-09 | Alza Corporation | Plurality of tiny pills in liquid dosage form |
| US5030454A (en) * | 1987-10-26 | 1991-07-09 | Alza Corporation | Method for delivering drug in tiny pills in liquid carrier |
| US5162110A (en) * | 1990-12-19 | 1992-11-10 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Binding theophylline to ion exchange resins |
| MY121142A (en) * | 1999-02-23 | 2005-12-30 | Smithkline Beecham Corp | Controlled release formulation for treating copd |
| GB0227948D0 (en) * | 2002-11-29 | 2003-01-08 | Cipla Ltd | Pharmaceutical combinations comprising b-2 adrenoreceptor agonists and xanthines |
| US20160199463A1 (en) * | 2014-12-15 | 2016-07-14 | The Johns Hopkins University | Hdac2 defends vascular endothelium from injury |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2752285A (en) * | 1950-10-09 | 1956-06-26 | Weissenburger Helmut | Process for the production of at least approximately neutral solutions of substituted xanthines |
| US2738303A (en) * | 1952-07-18 | 1956-03-13 | Smith Kline French Lab | Sympathomimetic preparation |
| US2881085A (en) * | 1953-11-09 | 1959-04-07 | Abbott Lab | Thin film coating for tablets and the like |
| US2853420A (en) * | 1956-01-25 | 1958-09-23 | Lowey Hans | Ethyl cellulose coatings for shaped medicinal preparations |
| BE556141A (forum.php) * | 1956-03-27 | |||
| US2954323A (en) * | 1958-10-06 | 1960-09-27 | Abbott Lab | Thin film coating for tablets and the like |
| US2987445A (en) * | 1958-10-10 | 1961-06-06 | Rohm & Haas | Drug composition |
| US2928770A (en) * | 1958-11-28 | 1960-03-15 | Frank M Bardani | Sustained action pill |
| NL122039C (forum.php) * | 1960-10-20 |
-
0
- BE BE636568D patent/BE636568A/xx unknown
- NL NL297088D patent/NL297088A/xx unknown
-
1961
- 1961-01-31 US US85978A patent/US3109775A/en not_active Expired - Lifetime
- 1961-05-11 GB GB17192/61A patent/GB935601A/en not_active Expired
-
1963
- 1963-08-24 DE DE19631467966 patent/DE1467966A1/de active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2484253A1 (fr) * | 1980-05-06 | 1981-12-18 | Bristol Myers Co | Comprime de theophylline a liberation prolongee |
| GR880100297A (en) * | 1987-05-08 | 1989-02-23 | Orion Yhtymae Oy | A new synthesis / composition |
| BE1000785A3 (fr) * | 1987-05-08 | 1989-04-04 | Orion Yhtymae Oy | Composition permettant d'administrer un medicament sous forme de gelules, d'une poudre ou d'un liquide. |
| FR2630912A1 (fr) * | 1987-05-08 | 1989-11-10 | Orion Yhtymae Oy | Composition permettant d'administrer un medicament sous forme de gelules, d'une poudre ou d'un liquide |
Also Published As
| Publication number | Publication date |
|---|---|
| US3109775A (en) | 1963-11-05 |
| NL297088A (forum.php) | |
| BE636568A (forum.php) | |
| DE1467966A1 (de) | 1969-02-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB935601A (en) | Delayed release preparations for asthma therapy containing theophylline | |
| US3119742A (en) | Method of preparing sustained release pharmaceutical pellets and product thereof | |
| GB1517480A (en) | Opiate analgesic formulation with a low potential for abuse | |
| US3080294A (en) | Sustained release type of pharmaceutical vehicles | |
| JP6139743B2 (ja) | ロキソプロフェン含有医薬組成物 | |
| GB906422A (en) | Improvements in and relating to prolonged acting pharmaceutical preparations | |
| ES424533A1 (es) | Metodo de prolongar la disponibilidad de sustancias farmaco-logicamente activas incluidas en composiciones farmaceuticasa base de alcohol alifatico e hidroxialcohilcelulosa. | |
| PT1518555E (pt) | Combinação analgésica de analgésicos de opióides e inibidor de ciclo-oxigenase-2 | |
| JPS61151125A (ja) | ジヒドロコデイン／イブプロフエン薬剤組成物及び方法 | |
| ES320356A1 (es) | Procedimiento para la preparaciën de pastillas medicinales comestibles | |
| Malone et al. | Desoxycholic acid enhancement of orally administered reserpine | |
| US2373763A (en) | Enteric coating | |
| WO2008044331A1 (en) | Solid preparation comprising ibuprofen and tranexamic acid | |
| JPS6024767B2 (ja) | 腸溶性硬カプセル剤 | |
| EP0094123A2 (en) | Therapeutic granules | |
| JP2008247822A (ja) | 鎮痛用組成物 | |
| US2427887A (en) | Analgesic composition | |
| Halpern | Analgesics and other drugs for relief of pain | |
| AU2021402764B2 (en) | Pharmaceutically stable soft capsule comprising two or more different compositions | |
| US20120045507A1 (en) | Stable soft capsule dosage form for acetylsalicylic acid | |
| ES247237A1 (es) | UN MÉTODO PARA LA PREPARACION DE GRáNULOS DE ACCIoN PROLONGADA | |
| Rosenblum | Bromide intoxication: I. Production of experimental intoxication in dogs | |
| Mascolo et al. | Antipyretic and analgesic studies of the ethanalic extract of Teclea nobilis delile | |
| GB791644A (en) | Barbiturate pharmaceutical preparations | |
| GB911482A (en) | Pharmaceutical tablets comprising a synergistic combination including salts of ª--phenoxyethyl penicillin |