GB933686A - New guanidine derivatives - Google Patents
New guanidine derivativesInfo
- Publication number
- GB933686A GB933686A GB46107/61A GB4610761A GB933686A GB 933686 A GB933686 A GB 933686A GB 46107/61 A GB46107/61 A GB 46107/61A GB 4610761 A GB4610761 A GB 4610761A GB 933686 A GB933686 A GB 933686A
- Authority
- GB
- United Kingdom
- Prior art keywords
- prepared
- reducing
- lithium aluminium
- aluminium hydride
- dimethylpyrrolidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002357 guanidines Chemical class 0.000 title 1
- 229940083094 guanine derivative acting on arteriolar smooth muscle Drugs 0.000 title 1
- -1 C1-4 alkyl radicals Chemical class 0.000 abstract 4
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 4
- 239000012280 lithium aluminium hydride Substances 0.000 abstract 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- WRXNJTBODVGDRY-UHFFFAOYSA-N 2-pyrrolidin-1-ylethanamine Chemical compound NCCN1CCCC1 WRXNJTBODVGDRY-UHFFFAOYSA-N 0.000 abstract 2
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 abstract 2
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 2
- UOLFIRYVZLZHDX-UHFFFAOYSA-N 2-(3,3-dimethylpyrrolidin-1-yl)ethanamine Chemical compound CC1(C)CCN(CCN)C1 UOLFIRYVZLZHDX-UHFFFAOYSA-N 0.000 abstract 1
- MSVUKJOODTYOBN-UHFFFAOYSA-N 2-[2-(3,3-dimethylpyrrolidin-1-yl)ethyl]guanidine Chemical compound CC1(C)CCN(CCN=C(N)N)C1 MSVUKJOODTYOBN-UHFFFAOYSA-N 0.000 abstract 1
- NJDDNCANXFHJLO-UHFFFAOYSA-N 3,3,4,4-tetramethylpyrrolidine Chemical compound CC1(C)CNCC1(C)C NJDDNCANXFHJLO-UHFFFAOYSA-N 0.000 abstract 1
- XGJPUQFWFRCCFO-UHFFFAOYSA-N 3,3,4,4-tetramethylpyrrolidine-2,5-dione Chemical compound CC1(C)C(=O)NC(=O)C1(C)C XGJPUQFWFRCCFO-UHFFFAOYSA-N 0.000 abstract 1
- LUCLDOSYMMNBFY-UHFFFAOYSA-N 3,3,4-trimethylpyrrolidin-2-one Chemical compound CC1CNC(=O)C1(C)C LUCLDOSYMMNBFY-UHFFFAOYSA-N 0.000 abstract 1
- VNMCWTPEADRUFW-UHFFFAOYSA-N 3,3,4-trimethylpyrrolidine Chemical compound CC1CNCC1(C)C VNMCWTPEADRUFW-UHFFFAOYSA-N 0.000 abstract 1
- IYZVTTRRGCJXGK-UHFFFAOYSA-N 3,3-dimethylpyrrolidin-2-one Chemical compound CC1(C)CCNC1=O IYZVTTRRGCJXGK-UHFFFAOYSA-N 0.000 abstract 1
- XBQNZPDIRJPFAI-UHFFFAOYSA-N 3,3-dimethylpyrrolidine Chemical compound CC1(C)CCNC1 XBQNZPDIRJPFAI-UHFFFAOYSA-N 0.000 abstract 1
- DWEXCXIEVRCDTE-UHFFFAOYSA-N 3-ethyl-3-methylpyrrolidine Chemical compound CCC1(C)CCNC1 DWEXCXIEVRCDTE-UHFFFAOYSA-N 0.000 abstract 1
- JFBZPFYRPYOZCQ-UHFFFAOYSA-N [Li].[Al] Chemical compound [Li].[Al] JFBZPFYRPYOZCQ-UHFFFAOYSA-N 0.000 abstract 1
- BJYUULIDUPIINH-UHFFFAOYSA-N [N+](=O)(O)[O-].N(C(=N)N)N1N=C(C(=C1)C)C Chemical compound [N+](=O)(O)[O-].N(C(=N)N)N1N=C(C(=C1)C)C BJYUULIDUPIINH-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- LTYRAPJYLUPLCI-UHFFFAOYSA-N glycolonitrile Chemical compound OCC#N LTYRAPJYLUPLCI-UHFFFAOYSA-N 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical group [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- ZVQXQPNJHRNGID-UHFFFAOYSA-N tetramethylsuccinonitrile Chemical compound N#CC(C)(C)C(C)(C)C#N ZVQXQPNJHRNGID-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEF32847A DE1174781B (de) | 1960-12-24 | 1960-12-24 | Verfahren zur Herstellung von Salzen von 1-(Guanidinoalkyl)-pyrrolidinen |
Publications (1)
Publication Number | Publication Date |
---|---|
GB933686A true GB933686A (en) | 1963-08-08 |
Family
ID=7094822
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB46107/61A Expired GB933686A (en) | 1960-12-24 | 1961-12-22 | New guanidine derivatives |
Country Status (5)
Country | Link |
---|---|
BE (1) | BE611886A (enrdf_load_html_response) |
DE (1) | DE1174781B (enrdf_load_html_response) |
FR (3) | FR1506253A (enrdf_load_html_response) |
GB (1) | GB933686A (enrdf_load_html_response) |
SE (1) | SE303498B (enrdf_load_html_response) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105859604A (zh) * | 2016-04-14 | 2016-08-17 | 梯尔希(南京)药物研发有限公司 | 一种氘代乙琥胺-d5的制备方法 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3371093A (en) * | 1961-08-08 | 1968-02-27 | Sterling Drug Inc | N-lower-alkyl and n-substituted-lower-alkyl-n-(and n, n-bis-)[(1-piperidyl)-lower-alkyl]amines |
IE52663B1 (en) * | 1980-04-02 | 1988-01-20 | Warner Lambert Co | Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids |
US4350704A (en) * | 1980-10-06 | 1982-09-21 | Warner-Lambert Company | Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR346879A (fr) * | 1903-10-10 | 1905-02-13 | Alba Thompson Kingsley | Système de serrure à moraillon |
-
1960
- 1960-12-24 DE DEF32847A patent/DE1174781B/de active Pending
-
1961
- 1961-12-22 SE SE12911/61A patent/SE303498B/xx unknown
- 1961-12-22 GB GB46107/61A patent/GB933686A/en not_active Expired
- 1961-12-22 BE BE611886A patent/BE611886A/fr unknown
- 1961-12-23 FR FR882967A patent/FR1506253A/fr not_active Expired
-
1962
- 1962-03-22 FR FR891925A patent/FR2124M/fr not_active Expired
- 1962-03-22 FR FR891924A patent/FR2123M/fr not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105859604A (zh) * | 2016-04-14 | 2016-08-17 | 梯尔希(南京)药物研发有限公司 | 一种氘代乙琥胺-d5的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
DE1174781B (de) | 1964-07-30 |
BE611886A (fr) | 1962-06-22 |
FR2123M (fr) | 1963-11-04 |
FR1506253A (fr) | 1967-12-22 |
SE303498B (enrdf_load_html_response) | 1968-09-02 |
FR2124M (fr) | 1963-11-04 |
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