GB932257A - Improvements in and relating to derivatives of estradiol - Google Patents

Improvements in and relating to derivatives of estradiol

Info

Publication number
GB932257A
GB932257A GB24463/60A GB2446360A GB932257A GB 932257 A GB932257 A GB 932257A GB 24463/60 A GB24463/60 A GB 24463/60A GB 2446360 A GB2446360 A GB 2446360A GB 932257 A GB932257 A GB 932257A
Authority
GB
United Kingdom
Prior art keywords
hydroxy
hemi
acetal
estradiol
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB24463/60A
Inventor
Poul Borrevang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KNUD ABILDGAARD
Original Assignee
KNUD ABILDGAARD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KNUD ABILDGAARD filed Critical KNUD ABILDGAARD
Priority to GB24463/60A priority Critical patent/GB932257A/en
Priority to CH823561A priority patent/CH401047A/en
Priority to BE606091A priority patent/BE606091A/en
Priority to ES0269112A priority patent/ES269112A1/en
Priority to FR874712A priority patent/FR1394M/en
Publication of GB932257A publication Critical patent/GB932257A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • E—FIXED CONSTRUCTIONS
    • E21—EARTH DRILLING; MINING
    • E21D—SHAFTS; TUNNELS; GALLERIES; LARGE UNDERGROUND CHAMBERS
    • E21D15/00—Props; Chocks, e.g. made of flexible containers filled with backfilling material
    • E21D15/14—Telescopic props
    • E21D15/44—Hydraulic, pneumatic, or hydraulic-pneumatic props

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mining & Mineral Resources (AREA)
  • Structural Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Geochemistry & Mineralogy (AREA)
  • Geology (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises steroid hemiacetals of the general formula:- <FORM:0932257/IV(a)/1> as the individual isomers and mixtures thereof, (in which formula R1 is an alkyl group containing from one to four carbon atoms and being substituted by at least one halogen atom, R2 is hydroxy or acyloxy group, and R4 is a hydroxy or acyloxy group, the isomerism being due to the carbon atom bearing the asterisk) and a process for their preparation by reacting the corresponding 17b -hydroxy compound with an aldehyde R1CHO, after which the hemi-acetal formed is recovered and purified, or if the corresponding esters are desired the hemi-acetal is acylated either before or after the separation and purification steps. Detailed examples illustrate the preparation of estradiol-17-chloral hemi-acetal and certain of its acylates, including the diacetate, diformate, dibenzoate and difuroate and 3-monoacylates, and also estradiol-17-butylchloral hemi-acetal and its diacetate.ALSO:Pharmaceutical preparations comprise estrogenically active estradiol compounds of the general formula <FORM:0932257/VI/1> in which R1 is an alkyl group having 1 to 4 carbon atoms and being substituted by at least one halogen atom, R2 is an hydroxy group or an acyloxy group and R4 is an hydroxy group or an acyloxy group. The compounds can be given orally or by injection, either in the form of an aqueous crystal suspension (particularly the hemiacetal esters) or in solution or dispersion in oil, and the formulations may contain other active ingredients, e.g. testosterone derivatives.
GB24463/60A 1960-07-13 1960-07-13 Improvements in and relating to derivatives of estradiol Expired GB932257A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GB24463/60A GB932257A (en) 1960-07-13 1960-07-13 Improvements in and relating to derivatives of estradiol
CH823561A CH401047A (en) 1960-07-13 1961-07-13 Process for the preparation of new estradiol derivatives
BE606091A BE606091A (en) 1960-07-13 1961-07-13 New derivatives of estradiol and method for their production.
ES0269112A ES269112A1 (en) 1960-07-13 1961-07-13 Improvements in and relating to derivatives of estradiol
FR874712A FR1394M (en) 1960-07-13 1961-10-02 New derivatives of estradiol.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB24463/60A GB932257A (en) 1960-07-13 1960-07-13 Improvements in and relating to derivatives of estradiol

Publications (1)

Publication Number Publication Date
GB932257A true GB932257A (en) 1963-07-24

Family

ID=10212098

Family Applications (1)

Application Number Title Priority Date Filing Date
GB24463/60A Expired GB932257A (en) 1960-07-13 1960-07-13 Improvements in and relating to derivatives of estradiol

Country Status (5)

Country Link
BE (1) BE606091A (en)
CH (1) CH401047A (en)
ES (1) ES269112A1 (en)
FR (1) FR1394M (en)
GB (1) GB932257A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112999330A (en) * 2021-03-18 2021-06-22 成都大学 Preparation method of estradiol benzoate and oxytocin long-acting suspension injection

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112999330A (en) * 2021-03-18 2021-06-22 成都大学 Preparation method of estradiol benzoate and oxytocin long-acting suspension injection

Also Published As

Publication number Publication date
FR1394M (en) 1962-07-09
BE606091A (en) 1962-01-15
ES269112A1 (en) 1962-04-16
CH401047A (en) 1965-10-31

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