GB915451A - Process for the production of pyridoxamine and its dihydrochloride - Google Patents

Process for the production of pyridoxamine and its dihydrochloride

Info

Publication number
GB915451A
GB915451A GB1106660A GB1106660A GB915451A GB 915451 A GB915451 A GB 915451A GB 1106660 A GB1106660 A GB 1106660A GB 1106660 A GB1106660 A GB 1106660A GB 915451 A GB915451 A GB 915451A
Authority
GB
United Kingdom
Prior art keywords
pyridoxal
pyridoxamine
dihydrochloride
schiff
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1106660A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck KGaA
Original Assignee
E Merck AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E Merck AG filed Critical E Merck AG
Publication of GB915451A publication Critical patent/GB915451A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/44—Palladium
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J21/00—Catalysts comprising the elements, oxides, or hydroxides of magnesium, boron, aluminium, carbon, silicon, titanium, zirconium, or hafnium
    • B01J21/18—Carbon

Abstract

Pyridoxamine or its dihydrochloride is obtained by hydrogenating a Schiff's base of pyridoxal in the presence of a precious metal catalyst. The Schiff's base may be produced by reacting pyridoxal or the hydroxy sulphonic acid of pyridoxal with an amine in aqueous solution have a pH of 8 to 9. In examples, pyridoxylidene - benzylamine or pyridoxal phenylhydrazone is dissolved in water and shaken with palladium charcoal and hydrogenated. The catalyst is filtered off and the filtrate is acidified with hydrochloric acid, concentrated and cooled to separate off pyridoxamine dihydrochloride.
GB1106660A 1959-04-04 1960-03-29 Process for the production of pyridoxamine and its dihydrochloride Expired GB915451A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEM0041057 1959-04-04

Publications (1)

Publication Number Publication Date
GB915451A true GB915451A (en) 1963-01-16

Family

ID=7303896

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1106660A Expired GB915451A (en) 1959-04-04 1960-03-29 Process for the production of pyridoxamine and its dihydrochloride

Country Status (2)

Country Link
CH (1) CH379498A (en)
GB (1) GB915451A (en)

Also Published As

Publication number Publication date
CH379498A (en) 1964-07-15

Similar Documents

Publication Publication Date Title
ES8106933A1 (en) Process for the production of D-Glucosone and D-Fructose.
IL45447A0 (en) Novel beta-diketones and process of recovering copper and nickel from their aqueous solutions by the use thereof
GB1420549A (en) Process for the production of gold powder
GB915451A (en) Process for the production of pyridoxamine and its dihydrochloride
GB858514A (en) Improvements in or relating to nitrile compounds, the preparation thereof and by-products of said preparation
GB1330848A (en) Preparation of 7-hydroxy-dihydrocitronellal
FR2440359A1 (en) PROCESS FOR PRODUCING INDOLINE DERIVATIVES
GB1452227A (en) Production of maminobenzenesulphonic acids
GB1009024A (en) Process for preparing aminophenols
ES263083A1 (en) Recrystallization of demethylchlortetracycline
GB940489A (en) Penicillins
GB808701A (en) Production of tetracyclinonitrile
SU873649A1 (en) Method of obtaining n-alkyl-2,6,6-trimethyl-bicyclo-(3.1.1.) hept-3-yl-amines
ES251102A1 (en) Process for preparing the amide of omega-aminocaprylic acid and amide product
NL296871A (en)
ES296050A1 (en) A procedure to produce bright nickel deposits (Machine-translation by Google Translate, not legally binding)
ES411143A1 (en) Preparation of 3-fluoro-d-alanine
GB928083A (en) Improvements in and relating to the electrodeposition of gold
GB807418A (en) Betaine ascorbate and its production
ES236407A1 (en) A method of recovery of tetracycline from solutions that contain it (Machine-translation by Google Translate, not legally binding)
GB1168305A (en) Preparation of 3,6-Diamino-Pseudocumene
ES238780A1 (en) A procedure for the continuous obtaining of exametilendiamina from the nitrile of adiptic acid (Machine-translation by Google Translate, not legally binding)
ES250349A1 (en) A procedure for the dissolution of metallic copper (Machine-translation by Google Translate, not legally binding)
ES248033A1 (en) A procedure for the preparation of alkaline salts (Machine-translation by Google Translate, not legally binding)
GB1499757A (en) Hydrogenation of nitrobenzoic acids