GB907828A - New diphenylmethane derivatives - Google Patents
New diphenylmethane derivativesInfo
- Publication number
- GB907828A GB907828A GB43107/60A GB4310760A GB907828A GB 907828 A GB907828 A GB 907828A GB 43107/60 A GB43107/60 A GB 43107/60A GB 4310760 A GB4310760 A GB 4310760A GB 907828 A GB907828 A GB 907828A
- Authority
- GB
- United Kingdom
- Prior art keywords
- trifluoromethyldiphenylcarbinol
- preparation
- lithium
- trifluoromethylbenzophenone
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
- C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/35—Preparation of halogenated hydrocarbons by reactions not affecting the number of carbon or of halogen atoms in the reaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C22/00—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom
- C07C22/02—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings
- C07C22/04—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings containing six-membered aromatic rings
- C07C22/08—Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings containing six-membered aromatic rings containing fluorine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises: (1) o-trifluoromethyldiphenylmethane and its preparation by reducing o-trifluoromethyldiphenylcarbinol with red phosphorus and hydriodic acid; (2) o-trifluoromethyldiphenylcarbinol and its preparation by reducing o-trifluoromethylbenzophenone, or by treating benzaldehyde with a compound of formula <FORM:0907828/IV (b)/1> where A is a lithium atom or Grignard residue of formula Mg-Halogen; and (3) o-trifluoromethylbenzophenone, its preparation by oxidation of o-trifluoromethyldiphenylcarbinol, and its preparation by reaction of an o-trifluoromethylbenzoyl halide and a phenyl magnesium halide or phenyl lithium; and (4) pharmaceutical compositions containing the above compounds. o-Trifluoromethyldiphenylcarbinol can also be made by treating o-benzylbenzoic acid with sulphur tetrafluoride. o-Trifluoromethylbenzophenone can also be prepared by reaction of an o-trifluoromethylbenzoyl halide with benzene in the presence of a Friedel-Crafts catalyst. Organometallic compounds of the general formula given above can be prepared from o-trifluoromethylbromobenzene by treatment with lithium or magnesium in ether, or by treatment of benzotrifluoride with a lithium alkyl. o-Trifluoromethylbromobenzene may be prepared from o-trifluoromethylaniline by the Sandmeyer or Gatterman reaction. Pharmaceutical compositions containing the above compounds may be administered orally or parenterally, e.g. as tablets, syrups or suspensions, and inhibit the metabolism of brain tissue.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL246529 | 1959-12-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB907828A true GB907828A (en) | 1962-10-10 |
Family
ID=19752088
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB43107/60A Expired GB907828A (en) | 1959-12-17 | 1960-12-14 | New diphenylmethane derivatives |
Country Status (4)
Country | Link |
---|---|
CH (2) | CH400110A (en) |
FR (1) | FR1302942A (en) |
GB (1) | GB907828A (en) |
NL (2) | NL246529A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4792635A (en) * | 1984-03-28 | 1988-12-20 | Bayer Aktiengesellschaft | Symmetric benzophenones substituted by groups containing fluorine |
-
0
- NL NL112600D patent/NL112600C/xx active
-
1959
- 1959-12-17 NL NL246529D patent/NL246529A/xx unknown
-
1960
- 1960-12-14 GB GB43107/60A patent/GB907828A/en not_active Expired
- 1960-12-16 CH CH1413460A patent/CH400110A/en unknown
- 1960-12-16 CH CH288765A patent/CH412841A/en unknown
- 1960-12-16 FR FR847216A patent/FR1302942A/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4792635A (en) * | 1984-03-28 | 1988-12-20 | Bayer Aktiengesellschaft | Symmetric benzophenones substituted by groups containing fluorine |
Also Published As
Publication number | Publication date |
---|---|
NL112600C (en) | |
CH412841A (en) | 1966-05-15 |
CH400110A (en) | 1965-10-15 |
FR1302942A (en) | 1962-09-07 |
NL246529A (en) |
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