GB907814A - Improvements in or relating to steroids and the manufacture thereof - Google Patents
Improvements in or relating to steroids and the manufacture thereofInfo
- Publication number
- GB907814A GB907814A GB1896461A GB1896461A GB907814A GB 907814 A GB907814 A GB 907814A GB 1896461 A GB1896461 A GB 1896461A GB 1896461 A GB1896461 A GB 1896461A GB 907814 A GB907814 A GB 907814A
- Authority
- GB
- United Kingdom
- Prior art keywords
- chlorine
- fluorine
- sulphate
- compound
- bromine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J75/00—Processes for the preparation of steroids in general
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises a compound having the formula <FORM:0907814/IV (b)/1> wherein X11 is chlorine or fluorine, X111 is bromine, iodine, chlorine, fluorine, or hydrogen and R2 is a b -hydroxy or keto group, and the preparation thereof by treating the corresponding 21-iodo compound in which R2 is b -OH with a reducing agent and then, if desired, oxidising the compound so obtained to produce the corresponding 11-keto derivative. As reducing agent sodium thiosulphate or sodium or potassium bisulphite may be used. Oxidation may be effected with CrO3, N-bromoacetamide or N-bromosuccinimide.ALSO:Anti-inflammatory compositions comprising compounds having the formula <FORM:0907814/VI/1> wherein X11 is chlorine or fluorine, X111 is bromine, iodine, chlorine, fluorine or hydrogen and R2 is a b -hydroxy or keto group, with or without the addition of an antibiotic (e.g. neomycin sulphate, novobiocin, bacitracin, circulin, polymyxin B sulphate, gramicidin, streptomycin sulphate, dihydrostreptomycin, oxytetracycline, chlortetracycline, tetracycline or chloramphenicol) and/or a sulphonamide, and a pharmaceutical diluent, are employed orally, parenterally or topically in tablets, ointments, lotions, jellies, creams, suppositories, bougies or aqueous suspensions. An ointment exemplified, incorporating 2-fluoro-11b ,17a -dihydroxy - 4 - pregnene - 3,20 - dione may contain in addition neomycin sulphate.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75940058A | 1958-09-08 | 1958-09-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB907814A true GB907814A (en) | 1962-10-10 |
Family
ID=25055501
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1896361A Expired GB907813A (en) | 1958-09-08 | 1959-09-07 | Improvements in or relating to steroids and the manufacture thereof |
GB3046859A Expired GB907812A (en) | 1958-09-08 | 1959-09-07 | Improvements in or relating to steroids and the manufacture thereof |
GB1896461A Expired GB907814A (en) | 1958-09-08 | 1959-09-07 | Improvements in or relating to steroids and the manufacture thereof |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1896361A Expired GB907813A (en) | 1958-09-08 | 1959-09-07 | Improvements in or relating to steroids and the manufacture thereof |
GB3046859A Expired GB907812A (en) | 1958-09-08 | 1959-09-07 | Improvements in or relating to steroids and the manufacture thereof |
Country Status (2)
Country | Link |
---|---|
CH (2) | CH388954A (en) |
GB (3) | GB907813A (en) |
-
1959
- 1959-08-28 CH CH458064A patent/CH388954A/en unknown
- 1959-08-28 CH CH7752159A patent/CH388953A/en unknown
- 1959-09-07 GB GB1896361A patent/GB907813A/en not_active Expired
- 1959-09-07 GB GB3046859A patent/GB907812A/en not_active Expired
- 1959-09-07 GB GB1896461A patent/GB907814A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GB907813A (en) | 1962-10-10 |
GB907812A (en) | 1962-10-10 |
CH388953A (en) | 1965-03-15 |
CH388954A (en) | 1965-03-15 |
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