GB907814A - Improvements in or relating to steroids and the manufacture thereof - Google Patents

Improvements in or relating to steroids and the manufacture thereof

Info

Publication number
GB907814A
GB907814A GB1896461A GB1896461A GB907814A GB 907814 A GB907814 A GB 907814A GB 1896461 A GB1896461 A GB 1896461A GB 1896461 A GB1896461 A GB 1896461A GB 907814 A GB907814 A GB 907814A
Authority
GB
United Kingdom
Prior art keywords
chlorine
fluorine
sulphate
compound
bromine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1896461A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB907814A publication Critical patent/GB907814A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises a compound having the formula <FORM:0907814/IV (b)/1> wherein X11 is chlorine or fluorine, X111 is bromine, iodine, chlorine, fluorine, or hydrogen and R2 is a b -hydroxy or keto group, and the preparation thereof by treating the corresponding 21-iodo compound in which R2 is b -OH with a reducing agent and then, if desired, oxidising the compound so obtained to produce the corresponding 11-keto derivative. As reducing agent sodium thiosulphate or sodium or potassium bisulphite may be used. Oxidation may be effected with CrO3, N-bromoacetamide or N-bromosuccinimide.ALSO:Anti-inflammatory compositions comprising compounds having the formula <FORM:0907814/VI/1> wherein X11 is chlorine or fluorine, X111 is bromine, iodine, chlorine, fluorine or hydrogen and R2 is a b -hydroxy or keto group, with or without the addition of an antibiotic (e.g. neomycin sulphate, novobiocin, bacitracin, circulin, polymyxin B sulphate, gramicidin, streptomycin sulphate, dihydrostreptomycin, oxytetracycline, chlortetracycline, tetracycline or chloramphenicol) and/or a sulphonamide, and a pharmaceutical diluent, are employed orally, parenterally or topically in tablets, ointments, lotions, jellies, creams, suppositories, bougies or aqueous suspensions. An ointment exemplified, incorporating 2-fluoro-11b ,17a -dihydroxy - 4 - pregnene - 3,20 - dione may contain in addition neomycin sulphate.
GB1896461A 1958-09-08 1959-09-07 Improvements in or relating to steroids and the manufacture thereof Expired GB907814A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75940058A 1958-09-08 1958-09-08

Publications (1)

Publication Number Publication Date
GB907814A true GB907814A (en) 1962-10-10

Family

ID=25055501

Family Applications (3)

Application Number Title Priority Date Filing Date
GB3046859A Expired GB907812A (en) 1958-09-08 1959-09-07 Improvements in or relating to steroids and the manufacture thereof
GB1896461A Expired GB907814A (en) 1958-09-08 1959-09-07 Improvements in or relating to steroids and the manufacture thereof
GB1896361A Expired GB907813A (en) 1958-09-08 1959-09-07 Improvements in or relating to steroids and the manufacture thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB3046859A Expired GB907812A (en) 1958-09-08 1959-09-07 Improvements in or relating to steroids and the manufacture thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB1896361A Expired GB907813A (en) 1958-09-08 1959-09-07 Improvements in or relating to steroids and the manufacture thereof

Country Status (2)

Country Link
CH (2) CH388954A (en)
GB (3) GB907812A (en)

Also Published As

Publication number Publication date
CH388954A (en) 1965-03-15
GB907812A (en) 1962-10-10
CH388953A (en) 1965-03-15
GB907813A (en) 1962-10-10

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