GB907309A - Water permeable tablet coating and method of application - Google Patents

Water permeable tablet coating and method of application

Info

Publication number
GB907309A
GB907309A GB548260A GB548260A GB907309A GB 907309 A GB907309 A GB 907309A GB 548260 A GB548260 A GB 548260A GB 548260 A GB548260 A GB 548260A GB 907309 A GB907309 A GB 907309A
Authority
GB
United Kingdom
Prior art keywords
oil
water
grms
alkylmethacrylate
copolymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB548260A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of GB907309A publication Critical patent/GB907309A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/005—Coating of tablets or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
    • G01S15/00—Systems using the reflection or reradiation of acoustic waves, e.g. sonar systems
    • G01S15/88—Sonar systems specially adapted for specific applications
    • G01S15/96—Sonar systems specially adapted for specific applications for locating fish

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Radar, Positioning & Navigation (AREA)
  • Remote Sensing (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Preparation (AREA)

Abstract

A fluid composition for coating tablets consists essentially of 10-25 grms. by weight of a water-soluble wax as hereinafter defined, 5-12 grms. by weight of a polymeric substance comprising a polyalkylmethacrylate, a copolymer of an alkyl acrylate with an alkylmethacrylate or a copolymer of an alkylmethacrylate with methacrylic acid, the alkyl having 1 to 4 carbon atoms, together with a non-aqueous solvent to a volume of 100 ml. of the ultimate composition. The wax is a water-soluble polyethylene glycol of melting point of at least 50 DEG C., glyceryl monostearate, diglycol stearate, and mixtures thereof. Optional ingredients are (a) dyes, lakes and pigments (b) water-insoluble glossing and polishing agents, e.g. beeswax, lanolin, stearic acid, cocoa butter and cetyl alcohol (c) plasticizers such as castor oil, mineral oil, corn oil, sesane oil and propylene glycol, alone or in admixture with a drying oil such as soya bean oil (d) surface-active agents, e.g. polyoxyethylene sorbitan derivatives and sulphated fatty alcohols (e) vinyl stearate (antisticking agent). Specifications 762,229 and 764,342 are referred to.ALSO:A coated solid medicament has the coating material in the form of a physiologically acceptable composition consisting essentially of a water-permeable combination of a water-soluble or water dispersible wax (A) and a film-forming "plastic" which is a polymer of an alkylmethacrylate a copolymer of an alkyl acrylate with an alkyl methacrylate or a copolymer of an alkylmethacrylate with methacrylic acid, the said alkyl having 1 to 4 carbon atoms (B). The copolymers contain 70 to 95% of the acrylate or methacrylate. The waxes are polyethylene glycols of melting point at least 50 DEG C., glyceryl monostearate and diglycol stearate, or mixtures thereof. Optional ingredients are (a) dyes, lakes and pigments; (b) water-insoluble glossing and polishing agents such as beeswax, lanolin, stearic acid, cocoa butter and cetyl alcohol (C); (c) plasticizers such as castor oil, mineral oil, corn oil, sesame oil and propylene glycol, alone or in admixture with a drying oil such as soy bean oil (D); (d) surface-active agents such as polyoxyethylene sorbitan derivatives and sulphated fatty alcohols; and (e) an anti-sticking agent which is vinyl stearate. The compositions contain 10 to 25 grms. of (A), 5 to 12 grms. of (B), not more than 1 grm. of (C) and not more than 2 grms. of (D) per 100 ml. of the fluid composition which is prepared by dissolving the components in a non-aqueous solvent such as acetone, ethanol, or mixtures thereof, methyl ethyl ketone or ethyl acetate. The finished coat contains 45 to 83% of (A) and 17 to 55% of (B) and not more than 5% of the optional components. Specifications 762,229 and 764,342 are referred to.
GB548260A 1959-02-18 1960-02-16 Water permeable tablet coating and method of application Expired GB907309A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79394559A 1959-02-18 1959-02-18

Publications (1)

Publication Number Publication Date
GB907309A true GB907309A (en) 1962-10-03

Family

ID=25161234

Family Applications (1)

Application Number Title Priority Date Filing Date
GB548260A Expired GB907309A (en) 1959-02-18 1960-02-16 Water permeable tablet coating and method of application

Country Status (6)

Country Link
BE (1) BE593353A (en)
DE (1) DE1250309B (en)
ES (1) ES255870A1 (en)
FR (1) FR1248796A (en)
GB (1) GB907309A (en)
NL (1) NL248552A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2430227A1 (en) * 1978-07-07 1980-02-01 Cm Ind Coating of suppositories with a dry coating compsn. - by evaporating a compsn. comprising a water-soluble polymer in a volatile organic solvent contg. an opacifier
EP0078079A2 (en) * 1981-10-26 1983-05-04 Norwich Eaton Pharmaceuticals, Inc. Nitrofurantoin dosage form
US4871546A (en) * 1987-06-29 1989-10-03 Sandoz Pharm. Corp. Gastrointestinal protective coating formulations
WO1992007553A1 (en) * 1990-10-24 1992-05-14 K.U. Leuven Research & Development Coating or matrix material for medicaments
US5436011A (en) * 1993-04-16 1995-07-25 Bristol-Myers Squibb Company Solid pharmaceutical dosage form and a method for reducing abrasion
US7037525B2 (en) 1997-02-14 2006-05-02 Novartis Ag Oxacarbazepine film-coated tablets

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2430227A1 (en) * 1978-07-07 1980-02-01 Cm Ind Coating of suppositories with a dry coating compsn. - by evaporating a compsn. comprising a water-soluble polymer in a volatile organic solvent contg. an opacifier
EP0078079A2 (en) * 1981-10-26 1983-05-04 Norwich Eaton Pharmaceuticals, Inc. Nitrofurantoin dosage form
EP0078079A3 (en) * 1981-10-26 1983-06-29 Norwich Eaton Pharmaceuticals, Inc. Nitrofurantoin dosage form
US4871546A (en) * 1987-06-29 1989-10-03 Sandoz Pharm. Corp. Gastrointestinal protective coating formulations
WO1992007553A1 (en) * 1990-10-24 1992-05-14 K.U. Leuven Research & Development Coating or matrix material for medicaments
US5436011A (en) * 1993-04-16 1995-07-25 Bristol-Myers Squibb Company Solid pharmaceutical dosage form and a method for reducing abrasion
US7037525B2 (en) 1997-02-14 2006-05-02 Novartis Ag Oxacarbazepine film-coated tablets

Also Published As

Publication number Publication date
DE1250309B (en)
NL248552A (en)
FR1248796A (en) 1960-12-23
ES255870A1 (en) 1960-10-01
BE593353A (en)

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