GB907310A - Tablet coating composition and method of applying - Google Patents
Tablet coating composition and method of applyingInfo
- Publication number
- GB907310A GB907310A GB548360A GB548360A GB907310A GB 907310 A GB907310 A GB 907310A GB 548360 A GB548360 A GB 548360A GB 548360 A GB548360 A GB 548360A GB 907310 A GB907310 A GB 907310A
- Authority
- GB
- United Kingdom
- Prior art keywords
- oil
- water
- vinyl acetate
- waxes
- grms
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2853—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
- C08L39/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
- C08L39/06—Homopolymers or copolymers of N-vinyl-pyrrolidones
Abstract
A fluid composition suitable for coating tablets consists essentially of about 10 to 25 parts by weight of a "water-soluble" wax as hereinafter defined and about 2 to 10 parts by weight of a polyvinylpyrrolidone-vinyl acetate copolymer per 100 ml. of the composition and a non-aqueous solvent for said wax and said copolymer. The waxes are polyethylene glycols of melting point of at least 50 DEG C., glyceryl monostearate and diglycol stearate, or mixtures thereof. The copolymers contain 30-70, and preferably 60% of vinylpyrrolidone and 70 to 30% and preferably 40% of vinyl acetate. Optional ingredients are (a) dyes, lakes and pigments (b) water-insoluble waxes such as beeswax, lanolin, stearic acid, cocoa butter and cetyl alcohol (c) plasticizers such as castor oil, mineral oil, corn oil, sesame oil and propylene glycol, alone or in admixture with a drying oil such as soybean oil (d) surface-active ingredients such as polyoxyethylene sorbitan derivatives and sulphated fatty alcohols and (e) cellulose acetate. Specifications 762,229 and 764,342 are referred to.ALSO:A coated solid medicament has the coating material in the form of a physiologically acceptable composition consisting essentially of a water permeable combination of a water-soluble or water-dispersible wax (A) and a polyvinylpyrrolidone vinyl acetate copolymer (B). The waxes are polyethylene glycols of melting point at least 50 DEG C., glyceryl monostearate and diglycol stearate, or mixtures thereof. The copolymers contain 30-70, and preferably 60% of polyvinylpyrrolidone and 70 to 30%, and preferably 40% of vinyl acetate. Optional ingredients are (a) dyes, lakes and pigments, (b) water-insoluble waxes such as beeswax, lanolin, stearic acid, cocoa butter and cetyl alcohol (C); (c) plasticizers such as castor oil, mineral oil, corn oil, sesame oil and propylene glycol, alone or in admixture with a drying oil such as soybean oil (D); (d) surface-active agents such as polyoxyethylene sorbitan derivatives and sulphated fatty alcohols; and (e) an antisticking agent which is cellulose acetate. The compositions contain 10 to 25 grms. of (A), 2 to 10 grms. of (B), not more than 1 grm. of (C) and not more than 2 grms. of (D) per 100 ml. of the fluid composition which is prepared by dissolving the components in a non-aqueous solvent such as acetone, ethanol or mixtures thereof. The finished coat contains 50-92% of (A), 8 to 50% of (B) and not more than 5% of the optional components. Specifications 762,229 and 764,342 are referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79394659A | 1959-02-18 | 1959-02-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB907310A true GB907310A (en) | 1962-10-03 |
Family
ID=25161236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB548360A Expired GB907310A (en) | 1959-02-18 | 1960-02-16 | Tablet coating composition and method of applying |
Country Status (4)
Country | Link |
---|---|
BE (1) | BE593354A (en) |
ES (1) | ES255871A1 (en) |
GB (1) | GB907310A (en) |
NL (1) | NL248553A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5436011A (en) * | 1993-04-16 | 1995-07-25 | Bristol-Myers Squibb Company | Solid pharmaceutical dosage form and a method for reducing abrasion |
WO2002064118A1 (en) * | 2001-02-13 | 2002-08-22 | Astrazeneca Ab | Novel modified release formulation |
-
0
- BE BE593354D patent/BE593354A/xx unknown
- NL NL248553D patent/NL248553A/xx unknown
-
1960
- 1960-02-16 GB GB548360A patent/GB907310A/en not_active Expired
- 1960-02-18 ES ES0255871A patent/ES255871A1/en not_active Expired
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5436011A (en) * | 1993-04-16 | 1995-07-25 | Bristol-Myers Squibb Company | Solid pharmaceutical dosage form and a method for reducing abrasion |
WO2002064118A1 (en) * | 2001-02-13 | 2002-08-22 | Astrazeneca Ab | Novel modified release formulation |
Also Published As
Publication number | Publication date |
---|---|
BE593354A (en) | |
NL248553A (en) | |
ES255871A1 (en) | 1960-10-01 |
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