GB905448A - Process for the manufacture of nitriles of tetracyclines - Google Patents
Process for the manufacture of nitriles of tetracyclinesInfo
- Publication number
- GB905448A GB905448A GB2978760A GB2978760A GB905448A GB 905448 A GB905448 A GB 905448A GB 2978760 A GB2978760 A GB 2978760A GB 2978760 A GB2978760 A GB 2978760A GB 905448 A GB905448 A GB 905448A
- Authority
- GB
- United Kingdom
- Prior art keywords
- butyl
- anhydrotetracycline
- tetracycline
- tert
- nitriles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Nitriles of tetracyclines are manufactured by a process wherein a compound which contains the ring system of tetracycline or of anhydrotetracycline, an unsubstituted acid amide group in ring A, known substitution at the 1- and 3-carbon atoms, and may contain at the 4- to 12a-carbon atoms substituents inert towards carbodiimides, or an acid addition salt of such compound if it is capable of forming acid addition salts, is reacted with a disubstituted carbodiimide at a temperature from 0 DEG C. to 100 DEG C. The carbodiimide may be dicyclohexyl-, di-tert.-butyl-, diisopropyl-, methyl-tert.-butyl-, n.butyl-cyclohexyl-, or isopropyl-tert.-butyl-carbodiimide. The reaction is preferably carried out in an inert solvent such as methanol, ethanol, propanol, isopropanol, dimethyl-formamide or dimethylsulphoxide. Examples describe the production of nitriles of tetracycline, anhydrotetracycline, tetracycline-methylbetaine, anhydrotetracyclinemethylbetaine, 4-epitetracycline, anhydro-4-epitetracycline and pyrrolidino-methyl-anhydrotetracycline. Specifications 766,512, 800,699 808,701, 808,702 and 872,991 are referred to.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF29248A DE1091564B (en) | 1959-08-27 | 1959-08-27 | Process for the preparation of nitriles of the tetracyclines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB905448A true GB905448A (en) | 1962-09-12 |
Family
ID=7093222
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2978760A Expired GB905448A (en) | 1959-08-27 | 1960-08-29 | Process for the manufacture of nitriles of tetracyclines |
Country Status (3)
| Country | Link |
|---|---|
| CH (1) | CH390905A (en) |
| DE (1) | DE1091564B (en) |
| GB (1) | GB905448A (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU40295B (en) * | 1977-04-07 | 1985-12-31 | Pliva Pharm & Chem Works | Process for preparing n2-tert.butyl-11a-halo-6-demethyl-6-deoxy-6-methylene tetracycline |
-
1959
- 1959-08-27 DE DEF29248A patent/DE1091564B/en active Pending
-
1960
- 1960-08-24 CH CH958660A patent/CH390905A/en unknown
- 1960-08-29 GB GB2978760A patent/GB905448A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH390905A (en) | 1965-04-30 |
| DE1091564B (en) | 1960-10-27 |
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