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Expired
Application number
GB30289/61A
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Laboratoires Francais de Chimiotherapie SA
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Laboratoires Francais de Chimiotherapie SA
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Publication of GB888430ApublicationCriticalpatent/GB888430A/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Hydrogenated Pyridines
(AREA)
Abstract
The invention comprises laevorotatory and racemic forms of 10-chlorodeserpidine, salts of 18b - (31,41,51 - trimethoxybenzoyloxy) - 10 - chloro - 16b - methoxycarbonyl - 17a - methoxy - D 3 - 20a - yohimbene, and a process for the preparation of 10-chlorodeserpidine by the reduction of an 18b -(31,41,51-trimethoxybenzoyl oxy) - 10 - chloro - 17a - methoxy - 16b - methoxycarbonyl - D 3 - 20a - yohimbene salt, preferably with zinc and perchloric acid. The salt may be prepared by cyclisation of 18b -(31,41,51-trimethoxybenzoyloxy) - 10 - chloro - 17a - methoxy - 16b - methoxycarbonyl - 3 - oxo - 2,3 - seco - 20a - yohimbane (e.g. with phosphorus oxychloride or sulphuryl or thionyl chloride), which in turn may be formed from a 1b -carboxy-methyl-2b -methoxycarbonyl - 3a - methoxy - 4b - acetoxy - 6b - formyl cyclohexane ester by condensation with 5-chlorotryptamine, reductive cyclisation and partial hydrolysis of the resulting 18b -acetoxy-10 - chloro - 17a - methoxy - 16b - methoxycarbonyl - 2,3 - 3,4 - diseco - D 4(21) - 20a - yohimbene-3-oic acid ester, e.g. with a metal hydride reducing agent, followed by esterification of the 18b - hydroxy - 10 - chloro - 17a - methoxy - 16b - methoxycarbonyl - 3 - oxo - 2,3 - seco - yohimbane, preferably with 3,4,5-trimethoxybenzoic anhydride in pyridine/triethylamine. Specifications 868,475, 888,411, 888,412, 888,414 and 888,429 also are referred to.
GB30289/61A1957-06-241958-04-11Improvements in or relating to derivatives of 20ª--yohimbane
ExpiredGB888430A
(en)
Process for the production of new basic esters of &aplha; -phenyl- &aplha; -isopropylglycolic acid or its acyl derivatives, and their salts and quaternary ammonium compounds