GB888413A - Substituted tryptamines - Google Patents

Substituted tryptamines

Info

Publication number
GB888413A
GB888413A GB11641/58A GB1164158A GB888413A GB 888413 A GB888413 A GB 888413A GB 11641/58 A GB11641/58 A GB 11641/58A GB 1164158 A GB1164158 A GB 1164158A GB 888413 A GB888413 A GB 888413A
Authority
GB
United Kingdom
Prior art keywords
chloro
methoxy
salt
tryptamines
tryptamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB11641/58A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Francais de Chimiotherapie SA
Original Assignee
Laboratoires Francais de Chimiotherapie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Francais de Chimiotherapie SA filed Critical Laboratoires Francais de Chimiotherapie SA
Publication of GB888413A publication Critical patent/GB888413A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

The invention comprises 4,5,6-trimethoxy-, 7 - chloro-, 4 - chloro - 7 - methoxy-, 6 - methoxy-7 - chloro-, 6 - chloro - 7 - methoxy-, 4,7 - dichloro- and 6,7-dichloro-tryptamine together with a process for the preparation of tryptamines of the general formula <FORM:0888413/IV (b)/1> (in which R1-R4 represent H, Cl or OCH3 with the proviso that one to three of R1-R4 must be H) by condensing an aniline diazonium salt of the formula <FORM:0888413/IV (b)/2> with a salt of 3-carboxy-2-piperidone, cyclising the resulting phenylhydrazone of 2 : 3-dioxopiperidine to give a 1-oxo-1,2,3,4-tetrahydro-b -carboline, saponifying to give a salt of a tryptamine-2-carboxylic acid, liberating the free acid and decarboxylating. Detailed examples illustrate the invention and also the use of the novel tryptamines as antimetabolites for the microbiological conversion of tryptophane to indole. Specifications 868,475, 868,477, 888,407, 888,408, 888,409, 888,410, 888,411, 888,412, 888,414 and 888,426 are referred to.
GB11641/58A 1957-08-02 1958-04-11 Substituted tryptamines Expired GB888413A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR888413X 1957-08-02

Publications (1)

Publication Number Publication Date
GB888413A true GB888413A (en) 1962-01-31

Family

ID=9376766

Family Applications (1)

Application Number Title Priority Date Filing Date
GB11641/58A Expired GB888413A (en) 1957-08-02 1958-04-11 Substituted tryptamines

Country Status (1)

Country Link
GB (1) GB888413A (en)

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