GB876721A - New steroid compounds - Google Patents

New steroid compounds

Info

Publication number
GB876721A
GB876721A GB6753/59A GB675359A GB876721A GB 876721 A GB876721 A GB 876721A GB 6753/59 A GB6753/59 A GB 6753/59A GB 675359 A GB675359 A GB 675359A GB 876721 A GB876721 A GB 876721A
Authority
GB
United Kingdom
Prior art keywords
cyclic
methyl
carboxylic acid
androsten
methyltestosterone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB6753/59A
Inventor
Bruno Camerino
Bianca Patelli
Giovanni Sala
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Priority to GB6753/59A priority Critical patent/GB876721A/en
Priority to BR116361/60A priority patent/BR6016361D0/en
Priority to CH198560A priority patent/CH385202A/en
Priority to BE588006A priority patent/BE588006A/en
Priority to FR836387A priority patent/FR260M/en
Publication of GB876721A publication Critical patent/GB876721A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Nutrition Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Physiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises steroid compounds of the general formula <FORM:0876721/IV (b)/1> wherein R represents hydrogen or an acyl group derived from an aliphatic, cyclic or partly cyclic carboxylic acid containing not more than 9 carbon atoms, and the preparation of 4,11b -dihydroxy-17a -methyltestosterone by dehydrating 4,5,11b ,17b -tetrahydroxy-17a -methyl-4-androsten-3-one in alkaline solution, e.g. by means of a methanolic solution of potassium hydroxide, and if necessary, neutralising the alkaline solution, e.g. with acetic acid and, when required, esterifying the 4-hydroxy compound with the required carboxylic acid chloride or acid anhydride, e.g. in the presence of a tertiary amine such as pyridine. Esters mentioned are the benzoate, b -phenylpropionate, b -cyclopentylpropionate, acetate, and propionate. In an example 11b -hydroxy-17a -methyltestosterone is treated with osmium tetroxide and the resulting 4,5,11b ,17b -tetrahydroxy-17a -methyl-4-androsten-3-one is dehydrated as above to form 4,11b -dihydroxy17a -methyl-testosterone which is then esterified to form the particular esters referred to above.ALSO:A therapeutic composition comprises at least one steroid of the general formula <FORM:0876721/VI/1> wherein R represents hydrogen or an acyl group derived from an aliphatic, cyclic or party cyclic carboxylic acid containing not more than 9 carbon atoms, and a pharmaceutically acceptable carrier therefor.
GB6753/59A 1959-02-26 1959-02-26 New steroid compounds Expired GB876721A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GB6753/59A GB876721A (en) 1959-02-26 1959-02-26 New steroid compounds
BR116361/60A BR6016361D0 (en) 1959-02-26 1960-01-21 PROCESS TO PREPARE 4-REPLACED-11-BETA-HYDROXY-17-ALPHA-METHYLTESTOSTERONE
CH198560A CH385202A (en) 1959-02-26 1960-02-22 Process for the preparation of the new 4,11B-dihydroxy-17a-methyltestosterone
BE588006A BE588006A (en) 1959-02-26 1960-02-25 New steroid compounds and their preparation process.
FR836387A FR260M (en) 1959-02-26 1960-08-22 A synthetic steroid, 4,11beta-dihydroxy-17alpha-methyl-testosterone.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB6753/59A GB876721A (en) 1959-02-26 1959-02-26 New steroid compounds

Publications (1)

Publication Number Publication Date
GB876721A true GB876721A (en) 1961-09-06

Family

ID=9820153

Family Applications (1)

Application Number Title Priority Date Filing Date
GB6753/59A Expired GB876721A (en) 1959-02-26 1959-02-26 New steroid compounds

Country Status (5)

Country Link
BE (1) BE588006A (en)
BR (1) BR6016361D0 (en)
CH (1) CH385202A (en)
FR (1) FR260M (en)
GB (1) GB876721A (en)

Also Published As

Publication number Publication date
FR260M (en) 1961-03-06
BE588006A (en) 1960-08-25
BR6016361D0 (en) 1973-05-24
CH385202A (en) 1964-12-15

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