GB874586A - Improvements in or relating to therapeutic compositions and the manufacture thereof - Google Patents
Improvements in or relating to therapeutic compositions and the manufacture thereofInfo
- Publication number
- GB874586A GB874586A GB26940/58A GB2694058A GB874586A GB 874586 A GB874586 A GB 874586A GB 26940/58 A GB26940/58 A GB 26940/58A GB 2694058 A GB2694058 A GB 2694058A GB 874586 A GB874586 A GB 874586A
- Authority
- GB
- United Kingdom
- Prior art keywords
- tablet
- acetylsalicylic acid
- prednisolone
- compression
- specified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 4
- 229960001138 acetylsalicylic acid Drugs 0.000 abstract 2
- 229910000019 calcium carbonate Inorganic materials 0.000 abstract 2
- 230000006835 compression Effects 0.000 abstract 2
- 238000007906 compression Methods 0.000 abstract 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 2
- CPJSUEIXXCENMM-UHFFFAOYSA-N phenacetin Chemical compound CCOC1=CC=C(NC(C)=O)C=C1 CPJSUEIXXCENMM-UHFFFAOYSA-N 0.000 abstract 2
- 150000003431 steroids Chemical class 0.000 abstract 2
- OAWXYINGQXLWOE-UHFFFAOYSA-N (2-acetyloxybenzoyl) 2-acetyloxybenzoate Chemical compound CC(=O)OC1=CC=CC=C1C(=O)OC(=O)C1=CC=CC=C1OC(C)=O OAWXYINGQXLWOE-UHFFFAOYSA-N 0.000 abstract 1
- DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 abstract 1
- DKSZLDSPXIWGFO-BLOJGBSASA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;phosphoric acid;hydrate Chemical compound O.OP(O)(O)=O.OP(O)(O)=O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC DKSZLDSPXIWGFO-BLOJGBSASA-N 0.000 abstract 1
- SVYCRJXQZUCUND-PQXSVQADSA-N (6s,8s,9s,10r,13s,14s,17r)-17-hydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2C(=O)C[C@]2(C)[C@@](O)(C(=O)CO)CC[C@H]21 SVYCRJXQZUCUND-PQXSVQADSA-N 0.000 abstract 1
- MYYIMZRZXIQBGI-ZHAFKKQJSA-N (8S,9S,10R,11S,13S,14S,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CC(F)C2=C1 MYYIMZRZXIQBGI-ZHAFKKQJSA-N 0.000 abstract 1
- VDOLRBJLUIFCGO-UHFFFAOYSA-N 10-(2-pyrrolidin-1-ylethyl)phenothiazine;hydrochloride Chemical compound Cl.C12=CC=CC=C2SC2=CC=CC=C2N1CCN1CCCC1 VDOLRBJLUIFCGO-UHFFFAOYSA-N 0.000 abstract 1
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 abstract 1
- VHRSUDSXCMQTMA-UWKORSIYSA-N 6-methylprednisolone Chemical compound C([C@@]12C)=CC(=O)C=C1C(C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)CO)CC[C@H]21 VHRSUDSXCMQTMA-UWKORSIYSA-N 0.000 abstract 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 abstract 1
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 abstract 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 abstract 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 abstract 1
- NPPQSCRMBWNHMW-UHFFFAOYSA-N Meprobamate Chemical compound NC(=O)OCC(C)(CCC)COC(N)=O NPPQSCRMBWNHMW-UHFFFAOYSA-N 0.000 abstract 1
- LCQMZZCPPSWADO-UHFFFAOYSA-N Reserpilin Natural products COC(=O)C1COCC2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12 LCQMZZCPPSWADO-UHFFFAOYSA-N 0.000 abstract 1
- QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 abstract 1
- -1 acetylsalicylic acid compound Chemical class 0.000 abstract 1
- 239000003470 adrenal cortex hormone Substances 0.000 abstract 1
- 230000001780 adrenocortical effect Effects 0.000 abstract 1
- 229940046978 chlorpheniramine maleate Drugs 0.000 abstract 1
- 229960004415 codeine phosphate Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229960004544 cortisone Drugs 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 229960000890 hydrocortisone Drugs 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 229960004815 meprobamate Drugs 0.000 abstract 1
- 229960003893 phenacetin Drugs 0.000 abstract 1
- 229960005205 prednisolone Drugs 0.000 abstract 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 abstract 1
- 229960004618 prednisone Drugs 0.000 abstract 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 abstract 1
- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 abstract 1
- 229960003147 reserpine Drugs 0.000 abstract 1
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 abstract 1
- 239000013589 supplement Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A medicinal tablet comprises a compression-coated outer layer containing acetylsalicylic acid or a compound convertible thereto on hydrolysis e.g. acetylsalicylic acid anhydride, and a bonded inner core containing a mixture of calcium carbonate and an adrenocortical steroid hormone. Specified adrenocortical steroids are cortisone, hydrocortisone, prednisone, prednisolone, 6 - fluorohydrocortisone, 6 - methylprednisone, 6 - methyl - prednisolone, 6 - fluoroprednisolone. Specified supplements which may be added to the composition are meprobamate, reserpine, codeine phosphate, acetophenetidin, chlorpheniramine maleate and pyrathiazine hydrochloride. The tablet should preferably be made under low humidity conditions with dried materials to provide a tablet with a water content of less than 0.9% by weight. Powdered steroid is added to granulated calcium carbonate and the mixture compressed to form the tablet core which is then compression-coated with the acetylsalicylic acid compound.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US874586XA | 1957-10-28 | 1957-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB874586A true GB874586A (en) | 1961-08-10 |
Family
ID=22205307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB26940/58A Expired GB874586A (en) | 1957-10-28 | 1958-08-21 | Improvements in or relating to therapeutic compositions and the manufacture thereof |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB874586A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2230185A (en) * | 1989-04-12 | 1990-10-17 | Warner Lambert Co | Differential release layered pharmaceutical tablet |
| US5320853A (en) * | 1991-05-20 | 1994-06-14 | Merrell Dow Pharmaceuticals Inc. | Controlled release formulation for pharmaceutical compounds |
| RU2153340C1 (en) * | 1999-12-14 | 2000-07-27 | Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" | Pharmaceutical composition regulating metabolic processes and method of its preparing |
| WO2002066002A3 (en) * | 2001-02-14 | 2003-01-30 | Glaxo Wellcome Sa | Pharmaceutical formulation |
| WO2004093850A1 (en) | 2003-04-24 | 2004-11-04 | Jagotec Ag | Tablet with coloured core |
| US9040085B2 (en) | 2003-04-24 | 2015-05-26 | Jagotec Ag | Delayed release tablet with defined core geometry |
| EP3028706A4 (en) * | 2013-08-02 | 2017-04-26 | Laboratorio Raam de Sahuayo, S.a. de C.V. | Pharmaceutical composition with antiinflammatory agents and production process |
| CN109602728A (en) * | 2019-01-18 | 2019-04-12 | 江苏福锌雨医药科技有限公司 | A kind of fludrocortisone acetate oral quick-dissolving film preparation and preparation method thereof |
-
1958
- 1958-08-21 GB GB26940/58A patent/GB874586A/en not_active Expired
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2230185A (en) * | 1989-04-12 | 1990-10-17 | Warner Lambert Co | Differential release layered pharmaceutical tablet |
| GB2230185B (en) * | 1989-04-12 | 1993-05-12 | Warner Lambert Co | Sustained release pharmaceutical compositions |
| US5320853A (en) * | 1991-05-20 | 1994-06-14 | Merrell Dow Pharmaceuticals Inc. | Controlled release formulation for pharmaceutical compounds |
| RU2153340C1 (en) * | 1999-12-14 | 2000-07-27 | Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" | Pharmaceutical composition regulating metabolic processes and method of its preparing |
| WO2002066002A3 (en) * | 2001-02-14 | 2003-01-30 | Glaxo Wellcome Sa | Pharmaceutical formulation |
| JP2006524230A (en) * | 2003-04-24 | 2006-10-26 | ヤゴテック アーゲー | Tablet with colored core |
| WO2004093850A1 (en) | 2003-04-24 | 2004-11-04 | Jagotec Ag | Tablet with coloured core |
| EP1615626B1 (en) * | 2003-04-24 | 2009-10-14 | Jagotec Ag | Tablet with coloured core |
| US9040085B2 (en) | 2003-04-24 | 2015-05-26 | Jagotec Ag | Delayed release tablet with defined core geometry |
| US9186332B2 (en) | 2003-04-24 | 2015-11-17 | Jagotec Ag | Delayed release tablet with defined core geometry |
| US9884021B2 (en) | 2003-04-24 | 2018-02-06 | Jagotec Ag | Delayed release tablet with defined core geometry |
| EP3028706A4 (en) * | 2013-08-02 | 2017-04-26 | Laboratorio Raam de Sahuayo, S.a. de C.V. | Pharmaceutical composition with antiinflammatory agents and production process |
| CN109602728A (en) * | 2019-01-18 | 2019-04-12 | 江苏福锌雨医药科技有限公司 | A kind of fludrocortisone acetate oral quick-dissolving film preparation and preparation method thereof |
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