GB874586A - Improvements in or relating to therapeutic compositions and the manufacture thereof - Google Patents

Improvements in or relating to therapeutic compositions and the manufacture thereof

Info

Publication number
GB874586A
GB874586A GB26940/58A GB2694058A GB874586A GB 874586 A GB874586 A GB 874586A GB 26940/58 A GB26940/58 A GB 26940/58A GB 2694058 A GB2694058 A GB 2694058A GB 874586 A GB874586 A GB 874586A
Authority
GB
United Kingdom
Prior art keywords
tablet
acetylsalicylic acid
prednisolone
compression
specified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB26940/58A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB874586A publication Critical patent/GB874586A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A medicinal tablet comprises a compression-coated outer layer containing acetylsalicylic acid or a compound convertible thereto on hydrolysis e.g. acetylsalicylic acid anhydride, and a bonded inner core containing a mixture of calcium carbonate and an adrenocortical steroid hormone. Specified adrenocortical steroids are cortisone, hydrocortisone, prednisone, prednisolone, 6 - fluorohydrocortisone, 6 - methylprednisone, 6 - methyl - prednisolone, 6 - fluoroprednisolone. Specified supplements which may be added to the composition are meprobamate, reserpine, codeine phosphate, acetophenetidin, chlorpheniramine maleate and pyrathiazine hydrochloride. The tablet should preferably be made under low humidity conditions with dried materials to provide a tablet with a water content of less than 0.9% by weight. Powdered steroid is added to granulated calcium carbonate and the mixture compressed to form the tablet core which is then compression-coated with the acetylsalicylic acid compound.
GB26940/58A 1957-10-28 1958-08-21 Improvements in or relating to therapeutic compositions and the manufacture thereof Expired GB874586A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US874586XA 1957-10-28 1957-10-28

Publications (1)

Publication Number Publication Date
GB874586A true GB874586A (en) 1961-08-10

Family

ID=22205307

Family Applications (1)

Application Number Title Priority Date Filing Date
GB26940/58A Expired GB874586A (en) 1957-10-28 1958-08-21 Improvements in or relating to therapeutic compositions and the manufacture thereof

Country Status (1)

Country Link
GB (1) GB874586A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2230185A (en) * 1989-04-12 1990-10-17 Warner Lambert Co Differential release layered pharmaceutical tablet
US5320853A (en) * 1991-05-20 1994-06-14 Merrell Dow Pharmaceuticals Inc. Controlled release formulation for pharmaceutical compounds
WO2002066002A2 (en) * 2001-02-14 2002-08-29 Glaxo Wellcome S.A. Pharmaceutical formulation
WO2004093850A1 (en) 2003-04-24 2004-11-04 Jagotec Ag Tablet with coloured core
US9040085B2 (en) 2003-04-24 2015-05-26 Jagotec Ag Delayed release tablet with defined core geometry
EP3028706A1 (en) * 2013-08-02 2016-06-08 Laboratorio Raam de Sahuayo, S.a. de C.V. Pharmaceutical composition with antiinflammatory agents and production process
CN109602728A (en) * 2019-01-18 2019-04-12 江苏福锌雨医药科技有限公司 A kind of fludrocortisone acetate oral quick-dissolving film preparation and preparation method thereof

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2230185A (en) * 1989-04-12 1990-10-17 Warner Lambert Co Differential release layered pharmaceutical tablet
GB2230185B (en) * 1989-04-12 1993-05-12 Warner Lambert Co Sustained release pharmaceutical compositions
US5320853A (en) * 1991-05-20 1994-06-14 Merrell Dow Pharmaceuticals Inc. Controlled release formulation for pharmaceutical compounds
WO2002066002A2 (en) * 2001-02-14 2002-08-29 Glaxo Wellcome S.A. Pharmaceutical formulation
WO2002066002A3 (en) * 2001-02-14 2003-01-30 Glaxo Wellcome Sa Pharmaceutical formulation
JP2006524230A (en) * 2003-04-24 2006-10-26 ヤゴテック アーゲー Tablet with colored core
WO2004093850A1 (en) 2003-04-24 2004-11-04 Jagotec Ag Tablet with coloured core
EP1615626B1 (en) * 2003-04-24 2009-10-14 Jagotec Ag Tablet with coloured core
JP4908200B2 (en) * 2003-04-24 2012-04-04 ヤゴテック アーゲー Tablet with colored core
US9040085B2 (en) 2003-04-24 2015-05-26 Jagotec Ag Delayed release tablet with defined core geometry
US9186332B2 (en) 2003-04-24 2015-11-17 Jagotec Ag Delayed release tablet with defined core geometry
US9884021B2 (en) 2003-04-24 2018-02-06 Jagotec Ag Delayed release tablet with defined core geometry
EP3028706A1 (en) * 2013-08-02 2016-06-08 Laboratorio Raam de Sahuayo, S.a. de C.V. Pharmaceutical composition with antiinflammatory agents and production process
EP3028706A4 (en) * 2013-08-02 2017-04-26 Laboratorio Raam de Sahuayo, S.a. de C.V. Pharmaceutical composition with antiinflammatory agents and production process
CN109602728A (en) * 2019-01-18 2019-04-12 江苏福锌雨医药科技有限公司 A kind of fludrocortisone acetate oral quick-dissolving film preparation and preparation method thereof

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