GB871500A - Improvements in or relating to the production of ascorbic and dehydroascorbic acids - Google Patents
Improvements in or relating to the production of ascorbic and dehydroascorbic acidsInfo
- Publication number
- GB871500A GB871500A GB3311356A GB3311356A GB871500A GB 871500 A GB871500 A GB 871500A GB 3311356 A GB3311356 A GB 3311356A GB 3311356 A GB3311356 A GB 3311356A GB 871500 A GB871500 A GB 871500A
- Authority
- GB
- United Kingdom
- Prior art keywords
- lactone
- ascorbic
- gulono
- rays
- acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/62—Three oxygen atoms, e.g. ascorbic acid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/08—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
- B01J19/081—Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor employing particle radiation or gamma-radiation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Furan Compounds (AREA)
Abstract
L-ascorbic acid or L-dehydroascorbic acid or their stereoisomers are obtained by irradiating with ionising radiation the g -lactone of the appropriate aldehexonic acid in aqueous solution and in the substantial absence of oxygen. The lactones are oxidised by the products resulting from the irradation of the water present to give the corresponding ascorbic acids, the dehydroascorbic acids being formed as the result of irradiation of the ascorbic acids thus produced. The dehydro-ascorbic acids may subsequently be converted to the ascorbic acids, e.g. by reaction with hydrogen sulphide. The reaction is preferably performed in dilute solution, the yield increasing with concentration. Yield is also increased by the presence of Ce++++, Fe+++ or Tl+++, i.e., an easily reducible ion. X rays, g rays, or b rays may be used for irradiation, or high energy electrons. The conversion rate is of the order of 1 molecule per 100 ev of energy absorbed. The ascorbic acid products may be separated by ion-exchange or electrodialysis thus enabling the process to be carried out in a cyclic manner. In Examples (1) D-gulono-g -lactone, D-glucono-g -lactone, L-galactono-g -lactone, and L-gulono-g -lactone are irradiated with 210 K.V.X rays in aqueous solution at a concentration of 5 x 10-4M and a dose rate of 1,24 x 1017 eV/ml/min. for 15 minutes to give the corresponding ascorbic acids. (2) D-gulono-g -lactone is converted to D-arabo-ascorbic acid in aqueous solution by p irradiation with 4MeV electrons. (3) As in (2) but using 60Cog radiation. Further reactions with 0,1M solutions of D-gulono-g -lactone give increased yields.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3311356A GB871500A (en) | 1956-10-30 | 1956-10-30 | Improvements in or relating to the production of ascorbic and dehydroascorbic acids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3311356A GB871500A (en) | 1956-10-30 | 1956-10-30 | Improvements in or relating to the production of ascorbic and dehydroascorbic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB871500A true GB871500A (en) | 1961-06-28 |
Family
ID=10348732
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3311356A Expired GB871500A (en) | 1956-10-30 | 1956-10-30 | Improvements in or relating to the production of ascorbic and dehydroascorbic acids |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB871500A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0779286A1 (en) * | 1995-12-14 | 1997-06-18 | F. Hoffmann-La Roche Ag | Preparation of ascorbic acid |
-
1956
- 1956-10-30 GB GB3311356A patent/GB871500A/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0779286A1 (en) * | 1995-12-14 | 1997-06-18 | F. Hoffmann-La Roche Ag | Preparation of ascorbic acid |
| US5702579A (en) * | 1995-12-14 | 1997-12-30 | Roche Vitamins Inc. | Process for making ascorbic acid |
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