GB868958A - Improvements in or relating to antibiotics - Google Patents

Improvements in or relating to antibiotics

Info

Publication number
GB868958A
GB868958A GB7197/59A GB719759A GB868958A GB 868958 A GB868958 A GB 868958A GB 7197/59 A GB7197/59 A GB 7197/59A GB 719759 A GB719759 A GB 719759A GB 868958 A GB868958 A GB 868958A
Authority
GB
United Kingdom
Prior art keywords
culture
organism
carbohydrate
nutrient
antibiotics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7197/59A
Inventor
Donald John Darling Hockenhull
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Priority to GB7197/59A priority Critical patent/GB868958A/en
Priority to BR117374/60A priority patent/BR6017374D0/en
Publication of GB868958A publication Critical patent/GB868958A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi
    • C12R2001/80—Penicillium

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

In the production of griseofulvin by the submerged aerobic culture of a griseofulvinproducing organism in a nutrient medium therefor, there is repeatedly added to the culture a nutrient carbohydrate serving to supply carbon and energy requirements of the organism, such additions of carbohydrate being in such quantities and at such times that the pH of the medium follows a controlled pH curve, which results in considerably increased titres as compared with a culture carried out under uncontrolled pH conditions. Preferably the pH is maintained between 6,6 and 7,6 during the bulk of the fermentation. Specifications 784,618 and 788,118 are referred to.
GB7197/59A 1959-03-02 1959-03-02 Improvements in or relating to antibiotics Expired GB868958A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB7197/59A GB868958A (en) 1959-03-02 1959-03-02 Improvements in or relating to antibiotics
BR117374/60A BR6017374D0 (en) 1959-03-02 1960-02-23 PERFECT PROCESS FOR THE PRODUCTION OF GRISEOFULVINE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7197/59A GB868958A (en) 1959-03-02 1959-03-02 Improvements in or relating to antibiotics

Publications (1)

Publication Number Publication Date
GB868958A true GB868958A (en) 1961-05-25

Family

ID=9828465

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7197/59A Expired GB868958A (en) 1959-03-02 1959-03-02 Improvements in or relating to antibiotics

Country Status (2)

Country Link
BR (1) BR6017374D0 (en)
GB (1) GB868958A (en)

Also Published As

Publication number Publication date
BR6017374D0 (en) 1973-05-24

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