GB866056A - Processes of production of new compounds with a "cortisone-like" action and productsthereof - Google Patents

Processes of production of new compounds with a "cortisone-like" action and productsthereof

Info

Publication number
GB866056A
GB866056A GB24629/57A GB2462957A GB866056A GB 866056 A GB866056 A GB 866056A GB 24629/57 A GB24629/57 A GB 24629/57A GB 2462957 A GB2462957 A GB 2462957A GB 866056 A GB866056 A GB 866056A
Authority
GB
United Kingdom
Prior art keywords
phenyl
acetic acid
cortisone
oxo
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB24629/57A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JOAC EMERICO VILAX
Original Assignee
JOAC EMERICO VILAX
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JOAC EMERICO VILAX filed Critical JOAC EMERICO VILAX
Publication of GB866056A publication Critical patent/GB866056A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Ketones having "cortisone-like" activity of the formulae: <FORM:0866056/IV (b)/1> or <FORM:0866056/IV (b)/2> wherein R1 and R2 are hydrogen, hydroxy, methoxy or ethoxy groups or R1 and R2 form a methylenedioxy ring; R3 is hydrogen or hydroxyl and R4 is a hydroxyl group or a hydroxyl group esterified with acetic acid are made by reacting a 1-phenyl-1-halo-propane or 1-phenyl-2-halopropane optionally bearing m- and/or phydroxy, methoxy, ethoxy or methylenedioxy substituents with a mol of 1-phenyl-2-oxo-3-propano or its acetate in the presence of an alkali-metal alcoholate and an inert solvent. Products containing ether groups may be dealkylated to hydroxyphenyl compounds e.g. by HBr and acetic acid. 1-Phenyl-2-oxo-3-propanol and its acetate used as starting materials are made by treating the acid halide (phenylacetyl halide) with diazomethane and treating the resulting diazoketone with mineral acid or acetic acid respectively. Specification 523,320 is referred to.
GB24629/57A 1956-08-02 1957-08-02 Processes of production of new compounds with a "cortisone-like" action and productsthereof Expired GB866056A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PT866056X 1956-08-02

Publications (1)

Publication Number Publication Date
GB866056A true GB866056A (en) 1961-04-26

Family

ID=20084155

Family Applications (1)

Application Number Title Priority Date Filing Date
GB24629/57A Expired GB866056A (en) 1956-08-02 1957-08-02 Processes of production of new compounds with a "cortisone-like" action and productsthereof

Country Status (1)

Country Link
GB (1) GB866056A (en)

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