GB860888A - Soya phosphatides and therapeutic compositions containing them - Google Patents
Soya phosphatides and therapeutic compositions containing themInfo
- Publication number
- GB860888A GB860888A GB7956/57A GB795657A GB860888A GB 860888 A GB860888 A GB 860888A GB 7956/57 A GB7956/57 A GB 7956/57A GB 795657 A GB795657 A GB 795657A GB 860888 A GB860888 A GB 860888A
- Authority
- GB
- United Kingdom
- Prior art keywords
- soya
- soya phosphatide
- fraction
- aluminium oxide
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 244000068988 Glycine max Species 0.000 title abstract 12
- 235000010469 Glycine max Nutrition 0.000 title abstract 12
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title abstract 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 abstract 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 14
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 7
- 239000000047 product Substances 0.000 abstract 5
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 239000003463 adsorbent Substances 0.000 abstract 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical group OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 239000003921 oil Substances 0.000 abstract 3
- 235000019198 oils Nutrition 0.000 abstract 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical class C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 2
- 241000282326 Felis catus Species 0.000 abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical group CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 abstract 2
- 239000003963 antioxidant agent Substances 0.000 abstract 2
- 230000003078 antioxidant effect Effects 0.000 abstract 2
- 230000036772 blood pressure Effects 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 238000001914 filtration Methods 0.000 abstract 2
- 239000000787 lecithin Substances 0.000 abstract 2
- 235000010445 lecithin Nutrition 0.000 abstract 2
- 239000000395 magnesium oxide Substances 0.000 abstract 2
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 abstract 2
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 239000000346 nonvolatile oil Substances 0.000 abstract 2
- -1 sorbitol Chemical class 0.000 abstract 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 abstract 1
- CFWRDBDJAOHXSH-SECBINFHSA-N 2-azaniumylethyl [(2r)-2,3-diacetyloxypropyl] phosphate Chemical compound CC(=O)OC[C@@H](OC(C)=O)COP(O)(=O)OCCN CFWRDBDJAOHXSH-SECBINFHSA-N 0.000 abstract 1
- QSHVAZMOLNGWSY-UHFFFAOYSA-N 3-butyl-4-methoxyphenol Chemical group CCCCC1=CC(O)=CC=C1OC QSHVAZMOLNGWSY-UHFFFAOYSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 abstract 1
- 229930091371 Fructose Natural products 0.000 abstract 1
- 239000005715 Fructose Substances 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 abstract 1
- 241000282414 Homo sapiens Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001298 alcohols Chemical class 0.000 abstract 1
- 239000010775 animal oil Substances 0.000 abstract 1
- 239000008135 aqueous vehicle Substances 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000007957 coemulsifier Substances 0.000 abstract 1
- 239000007859 condensation product Substances 0.000 abstract 1
- 239000002385 cottonseed oil Substances 0.000 abstract 1
- 235000012343 cottonseed oil Nutrition 0.000 abstract 1
- 239000003995 emulsifying agent Substances 0.000 abstract 1
- 239000000284 extract Substances 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 230000005484 gravity Effects 0.000 abstract 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 abstract 1
- 229960000367 inositol Drugs 0.000 abstract 1
- 238000001990 intravenous administration Methods 0.000 abstract 1
- 239000007951 isotonicity adjuster Substances 0.000 abstract 1
- 229940067606 lecithin Drugs 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000004006 olive oil Substances 0.000 abstract 1
- 235000008390 olive oil Nutrition 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 229920001451 polypropylene glycol Polymers 0.000 abstract 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 abstract 1
- 239000000473 propyl gallate Chemical group 0.000 abstract 1
- 229940075579 propyl gallate Drugs 0.000 abstract 1
- 235000010388 propyl gallate Nutrition 0.000 abstract 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000000600 sorbitol Substances 0.000 abstract 1
- 238000003756 stirring Methods 0.000 abstract 1
- 235000000346 sugar Nutrition 0.000 abstract 1
- 150000008163 sugars Chemical class 0.000 abstract 1
- 239000008158 vegetable oil Substances 0.000 abstract 1
- 235000013311 vegetables Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
- C07F9/103—Extraction or purification by physical or chemical treatment of natural phosphatides; Preparation of compositions containing phosphatides of unknown structure
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J7/00—Phosphatide compositions for foodstuffs, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Food Science & Technology (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A stable soya phosphatide fraction which does not depress blood pressure when injected into an sthetized cats and which is a satisfactory emulsifier for the oil used in a therapeutic fat product (see Group VI) is obtained by adsorbing the undesirable reactive materials present in a solution of a soya phosphatide fraction, obtained by extracting soya phosphatides with a monohydric lower molecular weight saturated aliphatic alcohol of 1 to 8 carbon atoms and of 85 to 100% concentration, by contacting said solution with an adsorbent selected from aluminium oxide, magnesium oxide or activated carbon, and then recovering the stable soya phosphatide fraction. Ethanol is the preferred monohydric alcohol but methanol, propanol and isopropanol or mixtures thereof are also specified. In a preferred embodiment a suitable product is obtained by stirring one part by weight of the ethanol soluble portion of soya phosphatide in about ten parts by volume of ethanol with about 2 parts by weight of aluminium oxide at room temperature, filtering off the aluminium oxide and then removing the alcohol under reduced pressure. When, however, the amount of aluminium oxide is reduced to 1.5 parts by weight, the product obtained is unsatisfactory. The activated carbon used as adsorbent should be a non-acid carbon. In another embodiment a commercial solid soya phosphatide mixture having a lower oil content than commercial lecithins is extracted three times with absolute ethanol at room temperature, the extracts are clarified by gravity filtration and then concentrated under reduced pressure and put on a column of aluminium oxide which is then eluted with 95% aqueous ethanol to yield an eluate fraction from which a suitable phosphatide fraction is recovered as residue after removing the alcohol under reduced pressure. It is stated that in the stable soya phosphatide product the proportion of lecithin has been increased while the proportion of cephalin components, especially the inositol, has been reduced.ALSO:A therapeutic fat product suitable for intravenous use in human beings comprises a metabolizable non-toxic fixed oil emulsified in an aqueous vehicle by a stable soya phosphatide fraction which does not depress blood pressure when injected into an sthetized cats and which is obtainable by adsorbing the undesirable reactive materials present in a solution of a soya phosphatide fraction, obtained by extracting soya phosphatides with a monohydric lower molecular weight saturated aliphatic alcohol of 1 to 8 carbon atoms, preferably ethanol, and of 85 to 100% concentration, by contacting said solution with an adsorbent selected from aluminium oxide, magnesium oxide or activated carbon, and then recovering the stable soya phosphatide fraction (see Group IV (b)). Isotonic agents, e.g. metabolizable sugars such as glucose and fructose or polyhydroxy alcohols, e.g. sorbitol, and an antioxidant, especially a metabolizable antioxidant of the phenolic type, e.g. a combination of tertiary butyl-4-hydroxy anisole, propyl gallate and citric acid may also be added and an ethylene oxide-polypropylene glycol condensation product in which the propylene units are located in non-terminal positions and are connected to each other in a chain may be added as co-emulsifier. Suitable fixed oils are naturally occurring vegetable and animal oils, and synthetic oils, cottonseed oil and olive oil being preferred.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US361088XA | 1956-04-30 | 1956-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB860888A true GB860888A (en) | 1961-02-15 |
Family
ID=21886661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7956/57A Expired GB860888A (en) | 1956-04-30 | 1957-03-11 | Soya phosphatides and therapeutic compositions containing them |
Country Status (3)
| Country | Link |
|---|---|
| CH (1) | CH361088A (en) |
| DE (1) | DE1177772B (en) |
| GB (1) | GB860888A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103254227A (en) * | 2013-05-08 | 2013-08-21 | 浙江大学 | Method for extracting and separating phosphatidylcholine by use of phenol extraction agent |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2718797C3 (en) * | 1977-04-27 | 1987-06-19 | A. Nattermann & Cie GmbH, 5000 Köln | Process for the production of flowable oil-containing purified phosphatidylcholine |
| DE3047048A1 (en) * | 1980-12-13 | 1982-07-29 | A. Nattermann & Cie GmbH, 5000 Köln | METHOD FOR SEPARATING OIL AND / OR PHOSPHATIDYLETHANOLAMINE FROM THESE ALCOHOL-SOLUBLE PHOSPHATIDYLCHOLINE PRODUCTS CONTAINING IT |
| DE3047011A1 (en) * | 1980-12-13 | 1982-07-22 | A. Nattermann & Cie GmbH, 5000 Köln | METHOD FOR SEPARATING OIL AND / OR PHOSPHATIDYLETHANOLAMINE FROM THESE ALCOHOL-SOLUBLE PHOSPHATIDYLCHOLINE PRODUCTS CONTAINING IT |
| DE3047012A1 (en) * | 1980-12-13 | 1982-07-22 | A. Nattermann & Cie GmbH, 5000 Köln | METHOD FOR SEPARATING ACYLATED PHOSPHOLIPID FROM THESE CONTAINING PHOSPHATIDYLCHOLINE PRODUCTS |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE617508C (en) * | 1932-06-22 | 1935-08-20 | I G Farbenindustrie Akt Ges | Process for the production of pure lecithin |
-
1957
- 1957-03-11 GB GB7956/57A patent/GB860888A/en not_active Expired
- 1957-04-01 CH CH361088D patent/CH361088A/en unknown
- 1957-04-18 DE DEU4504A patent/DE1177772B/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103254227A (en) * | 2013-05-08 | 2013-08-21 | 浙江大学 | Method for extracting and separating phosphatidylcholine by use of phenol extraction agent |
| CN103254227B (en) * | 2013-05-08 | 2016-06-08 | 浙江大学 | A kind of method adopting phenols extraction agent extracting and separating phosphatidylcholine |
Also Published As
| Publication number | Publication date |
|---|---|
| CH361088A (en) | 1962-03-31 |
| DE1177772B (en) | 1964-09-10 |
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