GB859245A - N-glycosides of 5-fluoro-cytosine and salts thereof and a process for the manufacture of same - Google Patents

N-glycosides of 5-fluoro-cytosine and salts thereof and a process for the manufacture of same

Info

Publication number
GB859245A
GB859245A GB10167/59A GB1016759A GB859245A GB 859245 A GB859245 A GB 859245A GB 10167/59 A GB10167/59 A GB 10167/59A GB 1016759 A GB1016759 A GB 1016759A GB 859245 A GB859245 A GB 859245A
Authority
GB
United Kingdom
Prior art keywords
glycosides
fluoro
salts
cytosine
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB10167/59A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB859245A publication Critical patent/GB859245A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)

Abstract

The invention comprises N1-glycosides of 5-fluorocytosine and medicinally acceptable acid addition salts thereof; and the preparation thereof by reacting an O-acyl ester of an N1-glycoside of 5-fluoro-uracil with a thiating agent in a basic medium, treating the O-acyl ester of an N1-glycaside of 4-thio-5-fluoruracil so formed with excess ammonia and, if desired, converting the product into an acid addition salt. Specification 824,614 is referred to.
GB10167/59A 1958-04-17 1959-03-24 N-glycosides of 5-fluoro-cytosine and salts thereof and a process for the manufacture of same Expired GB859245A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US859245XA 1958-04-17 1958-04-17

Publications (1)

Publication Number Publication Date
GB859245A true GB859245A (en) 1961-01-18

Family

ID=22194883

Family Applications (1)

Application Number Title Priority Date Filing Date
GB10167/59A Expired GB859245A (en) 1958-04-17 1959-03-24 N-glycosides of 5-fluoro-cytosine and salts thereof and a process for the manufacture of same

Country Status (1)

Country Link
GB (1) GB859245A (en)

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