GB840006A - Synthesis of substituted piperidines - Google Patents
Synthesis of substituted piperidinesInfo
- Publication number
- GB840006A GB840006A GB22944/57A GB2294457A GB840006A GB 840006 A GB840006 A GB 840006A GB 22944/57 A GB22944/57 A GB 22944/57A GB 2294457 A GB2294457 A GB 2294457A GB 840006 A GB840006 A GB 840006A
- Authority
- GB
- United Kingdom
- Prior art keywords
- phenyl
- prepared
- alkoxycarbonylpiperidines
- carbonates
- treating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
1 - (p - Aminophenethyl) - 4 - phenyl - 4 - alkoxycarbonylpiperidines of the general formula <FORM:0840006/IV(b)/1> (wherein R represents a C1-5 alkyl group) are prepared by treating the corresponding nitro compounds with hydrogen in the presence of a hydrogenation catalyst, and, if desired, are treated with acids to form acid addition salts. 1 - (p - Nitrophenethyl) - 4 - phenyl - 4 - alkoxycarbonylpiperidines are prepared by refluxing the carbonates of the corresponding 1-unsubstituted compounds with p-nitrophenethyl bromide in ethanol in the presence of sodium bicarbonate. 4-Phenyl-4-methoxy-, isoamoxy- and propoxycarbonylpiperidine carbonates are prepared by reacting 1-p-toluenesulphonyl-4-phenyl-4-carboxypiperidine with the appropriate alcohols in the presence of concentrated sulphuric acid, treating the products with aqueous caustic soda and adding excess carbon dioxide.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US840006XA | 1956-08-08 | 1956-08-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB840006A true GB840006A (en) | 1960-07-06 |
Family
ID=22182006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB22944/57A Expired GB840006A (en) | 1956-08-08 | 1957-07-19 | Synthesis of substituted piperidines |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB840006A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105037250A (en) * | 2015-06-11 | 2015-11-11 | 中国人民解放军63975部队 | Synthesis method of anileridine |
-
1957
- 1957-07-19 GB GB22944/57A patent/GB840006A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105037250A (en) * | 2015-06-11 | 2015-11-11 | 中国人民解放军63975部队 | Synthesis method of anileridine |
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