GB831067A - Improvements in or relating to uracil derivatives - Google Patents
Improvements in or relating to uracil derivativesInfo
- Publication number
- GB831067A GB831067A GB9023/56A GB902356A GB831067A GB 831067 A GB831067 A GB 831067A GB 9023/56 A GB9023/56 A GB 9023/56A GB 902356 A GB902356 A GB 902356A GB 831067 A GB831067 A GB 831067A
- Authority
- GB
- United Kingdom
- Prior art keywords
- uracil
- acid
- sulphonyl
- alkyl
- carbon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Uracil- and substituted uracil-5-sulphonyl halides are prepared by reacting a uracil as hereinafter defined with a halosulphonic acid at a temperature of at least 60 DEG C. for at least 6 hours. Preferably, at least 5 mols. of the halosulphonic acid are used per mol. of the uracil at temperatures from 60-120 DEG C. The uracil employed may be any pyrimidine-2 : 4-dione capable of reacting with a halo sulphonic acid to produce a carbon-sulphur bond at the 5-carbon position; the nitrogen atom in the 1-and/or 3-positions may carry alkyl or substituted alkyl radicals, e.g. methyl or chlormethyl radicals and the 6-carbon atom may bear an alkyl or substituted alkyl radical, in which the substituents are non-interfering with the halosulphonation in the 5-position, or may be attached to halogen, oxygen, sulphur or nitrogen and the latter three elements may themselves bear a hydrogen atom or an organic radical such as an alkyl, aryl or heterocyclic radical. Chlorsulphonic acid is preferred as reagent but the bromo- and fluoro analogues are also mentioned. The uracil-5-sulphonyl halide may be reacted with water, an alcohol, a phenol or an amine, e.g. dimethylamine or aniline to yield the corresponding sulphonic acid or derivative thereof. The uracil-5-sulphonyl halides may be reduced to the corresponding uracil-5-mercaptans by means of metallic zinc in an acidic medium and the mercaptan can be oxidized to the corresponding di-(uracyl-5-yl) disulphide, for example, by treatment with iodine in a strong aqueous alkaline medium or by refluxing with aqueous sulphuric acid. Examples describe the preparation of uracil-5 sulphonyl chloride and its conversion into the corresponding sulphonic acid and its sodium and toluidine salts and phenyl ester, and the sulphonanilide, N : N-dimethyl sulphonamide and 5-mercapto uracil and of 6-amino-uracil-5 sulphonyl chloride and the corresponding sulphonanilide.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US831067XA | 1955-03-23 | 1955-03-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB831067A true GB831067A (en) | 1960-03-23 |
Family
ID=22176211
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB9023/56A Expired GB831067A (en) | 1955-03-23 | 1956-03-22 | Improvements in or relating to uracil derivatives |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB831067A (en) |
-
1956
- 1956-03-22 GB GB9023/56A patent/GB831067A/en not_active Expired
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US2980679A (en) | Process for preparing heterocyclic sulfonamides | |
GB831067A (en) | Improvements in or relating to uracil derivatives | |
GB1476684A (en) | Fused-ring benzothiadiazepine and benzo-thiadiazocine deri vatives | |
GB727151A (en) | Improvements in derivatives of pyrimidine and methods of making the same | |
SE7408320L (en) | ||
GB677342A (en) | New pyrimidine derivatives and their use in the manufacture of pteridin derivatives | |
US3723531A (en) | 2-substituted-thio-2-cyclohexene-1-one and method for preparing them | |
GB961678A (en) | Process for the manufacture of thiuram disulphides | |
GB619515A (en) | Organic mercury compounds and process for preparing same | |
GB840384A (en) | Improvements in or relating to hemicyanine dyestuffs | |
GB886792A (en) | Process for the manufacture of a sulphonamide | |
GB1082061A (en) | 1,3-ethanopiperazine and its derivatives | |
US2996506A (en) | Hcxchb | |
GB1221327A (en) | Derivatives of benzoic acid | |
US3753918A (en) | Solution of alkali metal trithiocarbonate in dimethyl sulfoxide | |
GB589040A (en) | Improvements in or relating to the production of sulphonamides | |
GB1083553A (en) | Resorcinol derivatives and process for preparing them | |
SU520363A1 (en) | Derivatives of 3-thiocarbamylthiomethylbenzthiazolthione-2 as accelerators of sulfur vulcanization of rubber compounds based on general purpose rubbers | |
GB1166655A (en) | Improved Photographic Colour Process and Light-Sensitive Elements | |
US3200116A (en) | Process for the production of azapheno-thiazines carrying a substituent on the pyridine nucleus | |
GB798646A (en) | Improvements in and relating to derivatives of pyrimidine and the manufacture thereof | |
US3708491A (en) | 2-amino(perfluoroalkylsulfonamidophenyl)thiazoles | |
GB621644A (en) | Manufacture of derivatives of oxazolidine-2:4-dione | |
GB645901A (en) | Thio-ether substituted thiazoles and selenazoles and process of preparing the same | |
IE42384B1 (en) | Process for the preparation of a-oxothiodimethylamides |