GB816040A - Improvements in or relating to therapeutically useful compositions containing reserpine - Google Patents

Improvements in or relating to therapeutically useful compositions containing reserpine

Info

Publication number
GB816040A
GB816040A GB4163/58A GB416358A GB816040A GB 816040 A GB816040 A GB 816040A GB 4163/58 A GB4163/58 A GB 4163/58A GB 416358 A GB416358 A GB 416358A GB 816040 A GB816040 A GB 816040A
Authority
GB
United Kingdom
Prior art keywords
ether
carbon atoms
reserpine
alkyl group
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4163/58A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Pharmaceutische Fabrieken NV
Original Assignee
Koninklijke Pharmaceutische Fabrieken NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Pharmaceutische Fabrieken NV filed Critical Koninklijke Pharmaceutische Fabrieken NV
Publication of GB816040A publication Critical patent/GB816040A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/475Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

A therapeutic composition comprises reserpine in association with a synergistically-effective amount of the ortho-substituted betadialkylamino alkylbenzhydryl ether of general formula <FORM:0816040/VI/1> (in which R1 is an alkyl group having up to 6 carbon atoms or halogen, R2, R3 and R4 are hydrogen, an alkyl group having up to 6 carbon atoms or halogen, R5 is an alkyl group of 2-6 carbon atoms substituted in the b -position by the group NR6R7 and R6 and R7 are alkyl groups having up to 6 carbon atoms) or with a salt of such an ether. The preferred ether is b -dimethylamino ethyl o-methylbenzhydryl ether. The ether: reserpine ratio is preferably 15-100 : 1. Preparations for oral or parenteral administration may be made using solid or liquid excipients. Specifications 743,495 and 797,473, [Group IV (b)], are referred to.
GB4163/58A 1957-02-08 1958-02-07 Improvements in or relating to therapeutically useful compositions containing reserpine Expired GB816040A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL816040X 1957-02-08

Publications (1)

Publication Number Publication Date
GB816040A true GB816040A (en) 1959-07-08

Family

ID=19838876

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4163/58A Expired GB816040A (en) 1957-02-08 1958-02-07 Improvements in or relating to therapeutically useful compositions containing reserpine

Country Status (1)

Country Link
GB (1) GB816040A (en)

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