GB816040A - Improvements in or relating to therapeutically useful compositions containing reserpine - Google Patents
Improvements in or relating to therapeutically useful compositions containing reserpineInfo
- Publication number
- GB816040A GB816040A GB4163/58A GB416358A GB816040A GB 816040 A GB816040 A GB 816040A GB 4163/58 A GB4163/58 A GB 4163/58A GB 416358 A GB416358 A GB 416358A GB 816040 A GB816040 A GB 816040A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ether
- carbon atoms
- reserpine
- alkyl group
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
A therapeutic composition comprises reserpine in association with a synergistically-effective amount of the ortho-substituted betadialkylamino alkylbenzhydryl ether of general formula <FORM:0816040/VI/1> (in which R1 is an alkyl group having up to 6 carbon atoms or halogen, R2, R3 and R4 are hydrogen, an alkyl group having up to 6 carbon atoms or halogen, R5 is an alkyl group of 2-6 carbon atoms substituted in the b -position by the group NR6R7 and R6 and R7 are alkyl groups having up to 6 carbon atoms) or with a salt of such an ether. The preferred ether is b -dimethylamino ethyl o-methylbenzhydryl ether. The ether: reserpine ratio is preferably 15-100 : 1. Preparations for oral or parenteral administration may be made using solid or liquid excipients. Specifications 743,495 and 797,473, [Group IV (b)], are referred to.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NL816040X | 1957-02-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB816040A true GB816040A (en) | 1959-07-08 |
Family
ID=19838876
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB4163/58A Expired GB816040A (en) | 1957-02-08 | 1958-02-07 | Improvements in or relating to therapeutically useful compositions containing reserpine |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB816040A (en) |
-
1958
- 1958-02-07 GB GB4163/58A patent/GB816040A/en not_active Expired
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