GB810888A - Therapeutically valuable esters of 3:5:5-trimethylcyclohexanol and mandelic acid, and a process for the preparation thereof - Google Patents

Therapeutically valuable esters of 3:5:5-trimethylcyclohexanol and mandelic acid, and a process for the preparation thereof

Info

Publication number
GB810888A
GB810888A GB1066/57A GB106657A GB810888A GB 810888 A GB810888 A GB 810888A GB 1066/57 A GB1066/57 A GB 1066/57A GB 106657 A GB106657 A GB 106657A GB 810888 A GB810888 A GB 810888A
Authority
GB
United Kingdom
Prior art keywords
mandelic acid
preparation
trimethylcyclohexanol
esters
alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1066/57A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Pharmaceutische Fabrieken NV
Original Assignee
Koninklijke Pharmaceutische Fabrieken NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Pharmaceutische Fabrieken NV filed Critical Koninklijke Pharmaceutische Fabrieken NV
Publication of GB810888A publication Critical patent/GB810888A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C07C67/54—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention comprises a mixture of esters of 3 : 5 : 5-trimethylcyclohexanol and dl-mandelic acid which consists substantially of esters derived from the low-melting isomer of the alcohol and is completely or substantially free from esters derived from the higher-melting isomer of the alcohol, and the preparation thereof by esterification of 3 : 5 : 5-trimethylcyclohexanol with dl mandelic acid and distilling the crude ester mixture. An example describes the preparation, the distillation being carried out at a pressure of 10 mm. of mercury, while excluding oxygen, the fraction boiling at 184-8 DEG C. being collected.ALSO:The invention includes a pharmaceutical preparation comprising in admixture a mixture of esters of 3 : 5 : 5-trimethyl-cyclohexanol and dl-mandelic acid, which consists substantially of esters derived from the low-melting isomer of the alcohol and is completely or substantially free from esters derived from the high-melting isomer of the alcohol, with a therapeutically suitable vehicle.
GB1066/57A 1956-01-11 1957-01-10 Therapeutically valuable esters of 3:5:5-trimethylcyclohexanol and mandelic acid, and a process for the preparation thereof Expired GB810888A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL810888X 1956-01-11

Publications (1)

Publication Number Publication Date
GB810888A true GB810888A (en) 1959-03-25

Family

ID=19838664

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1066/57A Expired GB810888A (en) 1956-01-11 1957-01-10 Therapeutically valuable esters of 3:5:5-trimethylcyclohexanol and mandelic acid, and a process for the preparation thereof

Country Status (1)

Country Link
GB (1) GB810888A (en)

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