GB801537A - Improvements in or relating to the preparation of isonicotinic acid hydrazide - Google Patents

Improvements in or relating to the preparation of isonicotinic acid hydrazide

Info

Publication number
GB801537A
GB801537A GB365457A GB365457A GB801537A GB 801537 A GB801537 A GB 801537A GB 365457 A GB365457 A GB 365457A GB 365457 A GB365457 A GB 365457A GB 801537 A GB801537 A GB 801537A
Authority
GB
United Kingdom
Prior art keywords
isonicotinic acid
solvent
reaction
diluent
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB365457A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALBERT DAVID Ltd
Original Assignee
ALBERT DAVID Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ALBERT DAVID Ltd filed Critical ALBERT DAVID Ltd
Priority to GB365457A priority Critical patent/GB801537A/en
Publication of GB801537A publication Critical patent/GB801537A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/86—Hydrazides; Thio or imino analogues thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Isonicotinic acid hydrazide is prepared by the elimination of water from the hydrazonium salt of isonicotinic acid, or from a mixture of isonicotinic acid and hydrazine in which the said salt is formed in a solution but from which it has not been isolated, by heating said salt, or the solution thereof, in the presence of a solvent (defined as an organic liquid which keeps the hydrazonium salt of isonicotinic acid in solution) and a diluent (defined as an organic liquid other than a solvent which acts as a water entraining agent under the conditions of the reaction) to a temperature at which distillation occurs. One or more solvents and/or one or more diluents may be employed, specified solvents being n-butanol, n-amyl alcohol and ethanol, and specified diluents being toluene, xylene and benzene. A mixture of isonicotinic acid and hydrazine hydrate with the solvent and the diluent is preferably subjected to gradual distillation under reflux and the mixture of solvent and diluent from the distillate continuously or periodically led back to the reaction mixture during the course of the reaction, or is heated to 110 DEG to 170 DEG for a period of 10 to 30 hours and the solvent, diluent and water removed during and/or after the completion of the reaction by distillation. The isonicotinic acid hydrazide prepared as above is identified by conversion to the corresponding isonicotinyl hydrazone by reaction with benzaldehyde. The hydrazonium salt of isonicotinic acid is prepared by addition of hydrazine hydrate to an ethanol solution of isonicotinic acid followed by distillation to remove the ethanol.
GB365457A 1957-02-01 1957-02-01 Improvements in or relating to the preparation of isonicotinic acid hydrazide Expired GB801537A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB365457A GB801537A (en) 1957-02-01 1957-02-01 Improvements in or relating to the preparation of isonicotinic acid hydrazide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB365457A GB801537A (en) 1957-02-01 1957-02-01 Improvements in or relating to the preparation of isonicotinic acid hydrazide

Publications (1)

Publication Number Publication Date
GB801537A true GB801537A (en) 1958-09-17

Family

ID=9762400

Family Applications (1)

Application Number Title Priority Date Filing Date
GB365457A Expired GB801537A (en) 1957-02-01 1957-02-01 Improvements in or relating to the preparation of isonicotinic acid hydrazide

Country Status (1)

Country Link
GB (1) GB801537A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3007938A (en) * 1959-04-17 1961-11-07 Sterling Drug Inc 1-(3-indazolecarbonyl)-hydrazines and their preparation

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3007938A (en) * 1959-04-17 1961-11-07 Sterling Drug Inc 1-(3-indazolecarbonyl)-hydrazines and their preparation

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