GB781524A - Improvements in or relating to therapeutic compositions for the treatment of mastitis - Google Patents

Improvements in or relating to therapeutic compositions for the treatment of mastitis

Info

Publication number
GB781524A
GB781524A GB20857/55A GB2085755A GB781524A GB 781524 A GB781524 A GB 781524A GB 20857/55 A GB20857/55 A GB 20857/55A GB 2085755 A GB2085755 A GB 2085755A GB 781524 A GB781524 A GB 781524A
Authority
GB
United Kingdom
Prior art keywords
alginate
calcium
sodium
preparation
thickening agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB20857/55A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp
Pfizer Inc
Original Assignee
Pfizer Corp
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp, Pfizer Inc filed Critical Pfizer Corp
Publication of GB781524A publication Critical patent/GB781524A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines

Abstract

A composition effective against mastitis comprises calcium dioxytetracycline in an aqueous vehicle containing a non-toxic alkaline earth metal (including magnesium) alginate as a thickening agent and a pharmaceutically acceptable suspending agent. The alginate thickening agent may be prepared in situ by reacting sodium alginate with alkaline earth metal salts of hydroxy carboxylic acids of low molecular weight and low toxicity such as calcium lactate, magnesium lactate and calcium tartrate. Specified suspending agents include polyoxymethylene derivatives of fatty acid esters of anhydro sugar alcohols such as sorbitan. Stabilizing agents such as sodium bisulphite and sodium formaldehyde sulphoxylate and germicides such as parahydroxybenzoic acid esters, phenol and benzyl alcohol may also be present. The compositions may also include polymyxin in minor proportion. The preparation is preferably prepared by forming an aqueous suspension of the alginate thickening agent, adding the suspending agent and stabilizers, and homogenizing. A small quantity of this is added the antibiotic or antibiotics, and the germicides, and the remainder gradually stirred in and the preparation again homogenized. In an example, a preparation comprising calcium lactate, sodium alginate, a suspending agent, sodium bisulphite, calcium dioxytetracycline, polymyxin B sulphate, methyl p-hydroxy benzoate and propyl p-hydroxy benzoate is described. Specification 732,751 is referred to.
GB20857/55A 1954-07-27 1955-07-19 Improvements in or relating to therapeutic compositions for the treatment of mastitis Expired GB781524A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US781524XA 1954-07-27 1954-07-27

Publications (1)

Publication Number Publication Date
GB781524A true GB781524A (en) 1957-08-21

Family

ID=22142254

Family Applications (1)

Application Number Title Priority Date Filing Date
GB20857/55A Expired GB781524A (en) 1954-07-27 1955-07-19 Improvements in or relating to therapeutic compositions for the treatment of mastitis

Country Status (1)

Country Link
GB (1) GB781524A (en)

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