GB774064A - Steroids - Google Patents

Steroids

Info

Publication number
GB774064A
GB774064A GB23219/55A GB2321955A GB774064A GB 774064 A GB774064 A GB 774064A GB 23219/55 A GB23219/55 A GB 23219/55A GB 2321955 A GB2321955 A GB 2321955A GB 774064 A GB774064 A GB 774064A
Authority
GB
United Kingdom
Prior art keywords
represents hydrogen
acids
compounds
steroid
selected acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB23219/55A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB774064A publication Critical patent/GB774064A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises compounds having the formula <FORM:0774064/IV(b)/1> wherein R represents hydrogen or methyl, and R1 represents hydrogen or a hydrocarbon-carbonyl radical containing less than nine carbon atoms, and the preparation thereof wherein R1 represents hydrogen by contacting testosterone or 10-normethyltestosterone with oxygenating substances produced by the growing fungus Penicillium urticae. The 15-hydroxy steroid may be acylated to produce a 15-acyloxy steroid acylate, e.g. with ketene, ketenes of selected acids, selected acids, acid anhydrides and acid chlorides. Examples disclose the production of 15 - hydroxytestosterone, 15,17-diacetoxy-, 15,17 - diformyloxy -, 15,17 - di - [(b - cyclopentyl) propionyloxy] - 15,17 - dipropionyloxy-, 15,17-dibenzoyloxy-, and 15,17 - di(trimethylacetoxy) - 4 - androstene - 3 - one, and the corresponding 10-normethyl compounds. Other esters mentioned are the dimethyl acetoxy, butyryloxy, valeryloxy, hexanoyloxy, heptanoyloxy, octanoyloxy, phenylacetoxy, toluoyloxy, cyclopentylformyloxy, acryloxy and cyclohexylformyloxy, and the half and diesters of malonic, maleic, succinic, glutaric and adipic acids.
GB23219/55A 1954-08-17 1955-08-11 Steroids Expired GB774064A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US774064XA 1954-08-17 1954-08-17

Publications (1)

Publication Number Publication Date
GB774064A true GB774064A (en) 1957-05-01

Family

ID=22137865

Family Applications (1)

Application Number Title Priority Date Filing Date
GB23219/55A Expired GB774064A (en) 1954-08-17 1955-08-11 Steroids

Country Status (1)

Country Link
GB (1) GB774064A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004022065A1 (en) * 2002-09-05 2004-03-18 Pantarhei Bioscience B.V. Pharmaceutical application of 15- or 16- substituted testosterone analogues

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004022065A1 (en) * 2002-09-05 2004-03-18 Pantarhei Bioscience B.V. Pharmaceutical application of 15- or 16- substituted testosterone analogues
US7943602B2 (en) 2002-09-05 2011-05-17 Pantarhei Bioscience B.V. Pharmaceutical application of 15- or 16-substituted testosterone analogues
CN1694710B (en) * 2002-09-05 2012-09-05 潘塔希生物科学股份有限公司 Pharmaceutical application of 15- or 16- substituted testosterone analogues
CN101785775B (en) * 2002-09-05 2015-03-25 潘塔希生物科学股份有限公司 Pharmaceutical application of 15- or 16- substituted testosterone analogues

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