GB760643A - Preparation of dithiocarbamic acid derivatives - Google Patents

Abstract

Dithiocarbamates of the formula <FORM:0760643/IV(b)/1> where R1 is alkyl, aralkyl or aryl, R2 is alkyl or aralkyl (or R1, R2 together form a polymethylene or oxapolymethylene chain), and Q completes a thiazole, thiazoline or arylene-thiazole ring are prepared by reacting thiophosgene in the presence of water with an amine HNR1R2, a mercaptide of the formula <FORM:0760643/IV(b)/2> where M is an alkali or alkaline earth metal, and an inorganic basic alkali or alkaline earth metal compound; the last three are present during the reaction in at least a stoichiometric amount with respect to the thiophosgene. Preferably the latter is introduced into an agitated aqueous mixture of the other reactants, the temperature being maintained below 100 DEG C. e.g. at 10-40 DEG C. An organic solvent may also be present if desired. The mercaptide of the above formula may be derived from thiazole, alkylthiazoles, thiazoline, alkylthiazolines, benzthiazole or naphthothiazole, the latter being optionally ring-substituted by halogen, alkyl or nitro groups. Many suitable groups are mentioned for Q, R1 and R2. The metal M may be sodium, potassium, calcium, strontium, barium or magnesium. An example is given of the production of benzthiazol-2-yl-N:N-diethyldithiocarbamate.