GB736589A - Improvements in the separation of quinaldine from other bases - Google Patents
Improvements in the separation of quinaldine from other basesInfo
- Publication number
- GB736589A GB736589A GB27236/51A GB2723651A GB736589A GB 736589 A GB736589 A GB 736589A GB 27236/51 A GB27236/51 A GB 27236/51A GB 2723651 A GB2723651 A GB 2723651A GB 736589 A GB736589 A GB 736589A
- Authority
- GB
- United Kingdom
- Prior art keywords
- quinaldine
- urea
- complex
- solvent
- bases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Quinaldine is obtained from a concentrate derived by the fractional distillation of coal tar bases and containing quinaldine and other heterocyclic nitrogenous bases of similar boiling point, viz. boiling within 5 DEG C. of quinaldine, by a process comprising adding urea or thiourea to the concentrate, separating the resulting precipitate including a quinaldine-urea or -thiourea complex and decomposing the complex to yield quinaldine. The complex consists of two quinaldine molecules linked to the urea molecule but the reaction is quantitative using excess of the urea. The complex is preferably formed from aqueous urea in the presence of a solvent for quinaldine that is inert to both urea and quinaldine, such as toluene or other aromatic hydrocarbon, the reacting mixture being heated to above 80 DEG C. and then cooled to precipitate the complex. In place of the aromatic solvent, a solvent for urea and quinaldine may be used such as ethanol or the urea may be used in very dilute aqueous solution. The complex may be recovered by filtration and then decomposed by heating with water, preferably in the presence of a solvent for quinaldine which is inert to urea and quinaldine and separable from quinaldine by distillation. The recovered quinaldine may be further purified by re-crystallization of its complex from ethanol to remove traces of isoquinoline. An example is given.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB27236/51A GB736589A (en) | 1951-11-20 | 1951-11-20 | Improvements in the separation of quinaldine from other bases |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB27236/51A GB736589A (en) | 1951-11-20 | 1951-11-20 | Improvements in the separation of quinaldine from other bases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB736589A true GB736589A (en) | 1955-09-14 |
Family
ID=10256313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB27236/51A Expired GB736589A (en) | 1951-11-20 | 1951-11-20 | Improvements in the separation of quinaldine from other bases |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB736589A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0889035A1 (en) * | 1997-07-05 | 1999-01-07 | Rütgers VFT AG | Process for the purification of quinaldine |
| CN107382850A (en) * | 2017-09-25 | 2017-11-24 | 贾海亮 | A kind of 2 methylquinoline and its isomer and the separation method of isoquinolin |
-
1951
- 1951-11-20 GB GB27236/51A patent/GB736589A/en not_active Expired
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0889035A1 (en) * | 1997-07-05 | 1999-01-07 | Rütgers VFT AG | Process for the purification of quinaldine |
| US6020494A (en) * | 1997-07-05 | 2000-02-01 | Rutgers Vft Ag | Method of purifying quinaldine |
| CN1105107C (en) * | 1997-07-05 | 2003-04-09 | 拉特格斯Vft公开股份有限公司 | Method of purifying quinaldine |
| CN107382850A (en) * | 2017-09-25 | 2017-11-24 | 贾海亮 | A kind of 2 methylquinoline and its isomer and the separation method of isoquinolin |
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