GB729597A - Process for preparing the alcohol 1-phenyl-2-amino-1,3-propanediol - Google Patents

Process for preparing the alcohol 1-phenyl-2-amino-1,3-propanediol

Info

Publication number
GB729597A
GB729597A GB2300/53A GB230053A GB729597A GB 729597 A GB729597 A GB 729597A GB 2300/53 A GB2300/53 A GB 2300/53A GB 230053 A GB230053 A GB 230053A GB 729597 A GB729597 A GB 729597A
Authority
GB
United Kingdom
Prior art keywords
propanediol
phenyl
amino
alcohol
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2300/53A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Publication of GB729597A publication Critical patent/GB729597A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/02—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions involving the formation of amino groups from compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Abstract

1 - Phenyl - 2 - amino - 1 : 3 - propanediol is obtained by reducing an ester of phenylserine with lithium aluminium hydride in the presence of an organic solvent, the process being characterized in that the starting material is the cyclohexyl ester or in that a cyclic ether, e.g. tetrahydrofuran, is used as organic solvent. The ethyl ester may also be used as starting material in the latter case. In an example d-threo-1-phenyl - 2 - amino - 1,3 - propanediol is obtained from l-phenylserine-cyclohexyl ester. Specification 729,550 is referred to.
GB2300/53A 1952-09-19 1953-01-27 Process for preparing the alcohol 1-phenyl-2-amino-1,3-propanediol Expired GB729597A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT729597X 1952-09-19

Publications (1)

Publication Number Publication Date
GB729597A true GB729597A (en) 1955-05-11

Family

ID=11315198

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2300/53A Expired GB729597A (en) 1952-09-19 1953-01-27 Process for preparing the alcohol 1-phenyl-2-amino-1,3-propanediol

Country Status (1)

Country Link
GB (1) GB729597A (en)

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